Navigation Links
Ellison Medical Foundation awards more than $1 million to mid-career scientists
Date:8/25/2009

NEW YORK, August 25, 2009 -- Charleen T. Chu, MD, PhD, associate professor at the University of Pittsburgh and David M. Sabatini, MD, PhD, associate professor, Massachusetts Institute of Technology, received the 2009 Julie Martin Mid-Career Awards in Aging Research. Sponsored by The Ellison Medical Foundation, the grants provide funding of $550,000 to mid-career scientists whose research has great potential in advancing understanding of basic aging and its impact on age-related diseases. Through a partnership with the American Federation for Aging Research established in 2005, to date The Ellison Medical Foundation has disbursed $4.4 million to eight researchers.

In Parkinson's disease, dopaminergic neurons lose their ability to function and eventually die. Autophagy or "self-eating" is an important process by which damaged or unneeded structures in the cell are delivered to specialized compartments called lysosomes for digestion into building blocks that can be reused. The capacity for this recycling process, however, declines with age. Dr. Chu's research will develop methods to cause impairment of autophagy in adult mice to see if this factor contributes to the development of neurodegeneration on its own or in combination with genetic alterations that model familial parkinsonism. Dr. Chu's laboratory also studies the effects of overactivation of autophagy, which may also negatively alter neuritic and synaptic function. The ability to identify and correct age- or disease-related factors that disrupt the balance of autophagy could aid in the development of future therapies for neurological diseases.

The mammalian target of rapamycin (mTOR) signaling pathway is a key regulator of growth and metabolism in response to nutrients. mTOR signaling regulates protein synthesis, as well as cell size and proliferation, and has recently been linked to increased health and lifespan in a variety of organisms including yeast, worms, flies, and mice. Using mice with deletions of key mTOR genes, Dr. Sabatini seeks to learn more about the mechanisms underlying mTOR and its relationship to health and lifespan. The potential of such research is that one day this pathway may be able to be tweaked in people to provide some health benefits and protect against age-related diseases.

"These grants address two pressing needs: to sustain the promising work of mid-career researchers and to encourage less conservative approaches to advance research on aging that may be deemed too risky for other sources of funding," said Stephanie Lederman, executive director, American Federation for Aging Research. "We thank The Ellison Medical Foundation for their solid commitment to these scientists and the field."

"One of the great opportunities in a scientist's career is the point where he/she has recently achieved tenure status and can begin to take greater risks with less concern about career security," said Richard L. Sprott, executive director, The Ellison Medical Foundation. "We created this program in collaboration with AFAR in order to capitalize on the unique opportunities at this career stage by providing a funding source that encourages faster development of new ideas and approaches than is possible with more traditional funding."


'/>"/>

Contact: Stacey Harris
Stacey@afar.org
212-703-9977
American Federation for Aging Research
Source:Eurekalert

Related medicine news :

1. MSU engineering team designs innovative medical device
2. ATS Medical to Present at the 2007 Thomas Weisel Partners Healthcare Conference
3. Providence St. Joseph Medical Center, Caregivers Reach Agreement on a Union Contract
4. Owner and Operator of Florida Durable Medical Equipment Company Convicted of Medicare Fraud
5. Father and Daughter From Tanzania Receive Their First Medical Examination in Newport Beach
6. Doctors and medical ethicist discuss whether doctors should participate in capital punishment
7. Preparation for Natural Disasters Critical for People With Diabetes, Chronic Medical Conditions
8. Doctors and Medical Ethicist Discuss Whether Doctors Should Participate in Capital Punishment
9. Symmetry Medical Completes Acquisition Of Specialty Surgical Instruments
10. Milestone Scientific Announces Successful Completion of its Collaboration Agreement With Carticept Medical
11. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... “To Walk ... radioman on a B17 bomber named Edward Koontz. “To Walk Away” is the creation ... Scranton, who has published over two hundred manuscripts in chemistry and religion, as well ...
(Date:8/22/2017)... ... ... “Glimpses Of Light”: is a unique and thought inspiring guide toward self-discovery and ... author, J.M. Shepherd, a writer, teacher, traveler, and metaphysician, the author has spent most ... “Love is one of the least understood and yet most sought-after pleasures known to ...
(Date:8/22/2017)... ... August 22, 2017 , ... Although Labor Day is ... many communities have begun providing weekend displays, and numerous households celebrate the unofficial end ... can be downright terrifying for pets. , Kris Zambo, owner of Dynamite ...
(Date:8/21/2017)... Los Angeles, California (PRWEB) , ... August 21, ... ... Physicians is announcing the addition of two plastic surgery fellows for academic year ... is designed for candidates who have successfully completed residency in Plastic and Reconstructive ...
(Date:8/21/2017)... Milwaukee, WI (PRWEB) , ... August 21, 2017 ... ... recent years, with events taking place all over the country. , Outdoor running ... that marathon runners are at an increased risk of melanoma, and only half ...
Breaking Medicine News(10 mins):
(Date:8/1/2017)... --  CerSci Therapeutics , a non-opioid drug development firm ... received notice from the National Institute on Drug Abuse ... it has been awarded a Direct-to-Phase II Small Business ... with an additional $1,000,000 to follow in 2018. These ... their lead non-opioid drug candidate CT-044 to the Food ...
(Date:7/31/2017)... -- 7D Surgical, developer of ground breaking surgical navigation technologies, ... System to support its strategic sales plan in ... Virginia.  7D Surgical has entered into an exclusive sales representative ... facilities within those markets. ... Spartan Medical Purchases 7D ...
(Date:7/27/2017)... July 27, 2017  Zimmer Biomet Holdings, Inc. (NYSE ... ended June 30, 2017.  The Company reported second quarter ... over the prior year period, and an increase of ... basis points of contribution from the LDR Holding Corporation ... second quarter of 2016, or 0.3% on a constant ...
Breaking Medicine Technology: