Navigation Links
Eliminating Cell Receptor Prevents Infections in Animal Study
Date:7/22/2009

PHILADELPHIA, July 22 /PRNewswire-USNewswire/ -- New research from The Children's Hospital of Philadelphia sheds light on the role of cell receptors in acting as gatekeepers for infectious viruses. By using mice genetically engineered to lack a particular receptor in heart and pancreas cells, the study team prevented infection by a common virus that causes potentially serious diseases in humans.

"This finding is a step to understanding how cell receptors operate in infections," said study leader Jeffrey M. Bergelson, M.D., a pediatric infectious diseases specialist at The Children's Hospital of Philadelphia. "Scientists have identified receptors for many viruses that cause disease," said Bergelson, "but it is not always clear whether the receptors found in cell cultures actually play a role in the disease process. In this case, we confirmed that this receptor really is involved in the disease."

The current study, publishing July 23 in Cell Host and Microbe, focused on the coxsackievirus and adenovirus receptor (CAR), which Bergelson discovered in 1997. He previously found that, in cell culture, Group B coxsackieviruses (CVBs) manipulate cell signals to bind to the CAR.

CVBs are common in humans, usually causing minor, transient infections. However, this virus may at times cause potentially severe infections, such as myocarditis (in the heart) and viral meningitis (in the lining of the brain). CVB may also infect the pancreas, causing pancreatitis, and is suspected to contribute to childhood-onset diabetes.

Bergelson noted that his current animal study finding does not have immediate implications for changes in patient care, although discoveries in basic biology often lay the foundation for future clinical treatments in unforeseen ways.

Viruses may have interactions in living organisms that differ greatly from their interactions in cell cultures. They may attack specific tissues in humans or animals, but without binding to the cellular receptors identified in cultured cells. For instance, adenovirus infects the liver, but it bypasses identified adenovirus receptors in that organ. Instead the virus engages in complicated interactions with blood proteins and unidentified molecules in the liver.

Therefore, Bergelson and colleagues set out to discover whether CVB interacts with its receptor to cause pancreatitis and myocarditis in a special breed of mice. By manipulating genes in the pancreas and heart that generate CAR in those organs, Bergelson's team prevented the mice from forming CAR at those sites. Subsequently, those mice had virus levels in the pancreas a thousand times smaller than in control animals, and had significantly less tissue damage and inflammation. A similar protective effect occurred in the mice designed to lack CAR in their heart cells.

The results indicate that CAR is the receptor used by coxsackieviruses to infect the heart and pancreas and to cause direct injury to tissues. In some patients, recovery from coxsackievirus infection is followed by slowly progressive inflammation and heart damage. Bergelson's lab is interested in whether this long-term damage also depends on virus interaction with CAR.

Grants from the National Institutes of Health, the American Heart Association and the ACVP/STP Coalition for Veterinary Pathology Fellows supported this research. Bergelson's co-authors were Nicole L. Kallewaard, Ph.D., Lili Zhang, Jin-Wen Chen, Ph.D., and Marta Guttenberg, M.D., all from Children's Hospital; and Melissa D. Sanchez, D.V.M., Ph.D., of the University of Pennsylvania School of Veterinary Medicine.

Kallewaard et al, "Tissue-specific deletion of the coxsackievirus and adenovirus receptor (CAR) protects mice from virus-induced pancreatitis and myocarditis," Cell Host and Microbe, published July 23, 2009.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking second in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 430-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

    Contact: John Ascenzi
    Phone: (267) 426-6055
    Ascenzi@email.chop.edu



'/>"/>
SOURCE The Children's Hospital of Philadelphia
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Eliminating Influence of Hyperactive Genes That Help Regulate Cell Development Shows Potential as Additional Target Therapy for Chronic Myelogenous Leukemia
2. On Heels of SCHIP Veto, President Advocates Eliminating Federal Funding for Training Childrens Doctors
3. Electrolyzed Water Gives Boost to Eliminating Food-Borne Bacteria Such as Salmonella, E. coli and Listeria Murrays Chicken to be First Poultry Processor to Utilize New Technology in its Food Sanitation Process
4. Bread mold may hold secret to eliminating disease-causing genes
5. ASP Launches STERRAD(R) Sterility Guide - Eliminating Paperwork and Ensuring Compliance
6. Malaria No More Congratulates President-elect Obama and the New Congress and Urges Them to Uphold Their Strong Commitment to Eliminating Malaria
7. 3T MRI can detect wrist ligament tears, possibly eliminating need for invasive arthroscopy
8. Video: Pampers Together with Actress Salma Hayek Helps UNICEF Move Closer Toward Goal of Eliminating Deadly Tetanus Through Global One Pack = One Vaccine Campaign
9. The New Crystalens HD Gives Many Baby Boomers and Seniors an Opportunity to See Clearly at All Distances while Reducing or Eliminating the Need for Glasses
10. Hebrew University scientist develop technique for eliminating reblockage of arteries
11. Legislation Aims to Increase Access to Physical Therapist Services By Eliminating Physician Referral Requirement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... February 20, 2017 , ... Today, ... Biscom Document Router (BDR), the first IoT device from Biscom designed to deliver ... Biscom will debut BDR at HIMSS17 and will be conducting demonstrations ...
(Date:2/20/2017)... ... February 20, 2017 , ... Johns Hopkins All Children's Hospital celebrated ... topping out ceremony on Friday marked the halfway point of construction and lifting of ... Fall 2018, will serve as a center for innovation aimed at finding new discoveries ...
(Date:2/19/2017)... ... 19, 2017 , ... Braun Industries will be participating as an exhibitor at ... take place February 23-25, 2017 at the Calvin L. Rampton Salt Palace Convention Center ... new ambulances on display. , “JEMS is a leader in EMS ...
(Date:2/18/2017)... ... February 17, 2017 , ... Focused ... innovation in the industry, according to the recent NEJM Catalyst Insights Report on ... of the NEJM Catalyst Insights Council, a qualified group of U.S. executives, clinical ...
(Date:2/18/2017)... La. (PRWEB) , ... February 18, 2017 , ... ... released today provides the latest information and contact points to easily connect elderly ... home care, assisted living, and elder-care funding. It also conveys material on this ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... YORK, Feb. 20, 2017 Report analyzes ... by the following Product Segments: Ambulatory Infusion Pumps, ... Infusion Pumps, PCA Infusion Pumps, and Syringe Infusion ... the US, Canada, Japan, Europe, Asia-Pacific, Latin America, ... full report: http://www.reportlinker.com/p04707120-summary/view-report.html Annual estimates ...
(Date:2/20/2017)... This report analyzes the worldwide markets for Human ... comprehensive analytics for the US, Canada , ... Asia-Pacific , and Rest of World. ... Annual estimates and forecasts are provided for the period ... for these markets. Market data and analytics are derived from ...
(Date:2/20/2017)... 2017 The Global PSA Oxygen Concentrators ... a comprehensive analysis of the PSA Oxygen Concentrators market. From ... classification, application, and industry chain overview are all covered in ... SWOT analysis, and investment return analysis of the PSA Oxygen ... ...
Breaking Medicine Technology: