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Elevated protein levels in cardiac muscles could predict mortality following angioplasty
Date:5/12/2011

,353 patients. A meta-analysisthe largest to dateof study findings showed that post-PCI levels of cTnT or cTnI were elevated in 26% and 34% of patients, respectively. The follow-up period of participants in the studies analyzed ranged from 3 to 67 months.

"Our analysis demonstrates that post-procedural elevation of cTnT or cTnI provides long-term prognostic information regarding mortality or myocardial infarction," said Dr. Feldman. Results showed that long-term all-cause mortality in patients with elevated cardiac troponin levels after PCI was 5.8% compared to only 4.4% in patients who did not experience an elevation in the cardiac enzymes. Adverse events (death or heart attack) following elective angioplasty were significantly higher in patients with elevated cTnT or cTnI levels (9.2%) compared to those without cTn elevations (5.3%). "Routine monitoring of peri-procedural cTn levels and more intensive outpatient monitoring and treatment of patients with cTn elevations following elective PCI may help to improve long-term adverse outcomes in these patients," Feldman advised.


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