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Elevated protein levels in cardiac muscles could predict mortality following angioplasty
Date:5/12/2011

New research shows that elevated levels of cardiac troponin T (cTnT) or I (cTnI) in patients who had angioplasty indicate a higher risk of all-cause mortality and long-term adverse events such as heart attack. Routine monitoring of these protein levels following nonemergent percutaneous coronary intervention (PCI) could improve long-term outcomes for these patients. Details of the analysis are available online in Catheterization and Cardiovascular Interventions, a peer-reviewed journal of The Society for Cardiovascular Angiography and Interventions (SCAI).

More than one million Americans undergo coronary angioplasty each year to improve blood flow in blocked or narrowed arteries leading to the heart, according to the National Heart, Lung and Blood Institute. In cases where elective PCI was performed medical evidence has found that up to 30% of these patients experience minor elevations in cardiac enzymes, particularly levels of creatine kinase muscle-brain (CK-MB), which are associated with an increase in in-hospital adverse cardiac events. Greater elevations of CK-MB are associated with greater long-term mortality.

Recent studies suggest that elevated levels of cardiac troponins T or I are more specific indicators of cardiac muscle damage than CK-MB. However, conflicting data have been published in medical literature regarding the association between cardiac troponin elevation post-PCI and adverse cardiac events. In the current meta-analysis, Dmitriy Feldman, MD, FSCAI, and colleagues from New York Presbyterian Hospital and Weill Cornell Medical College, assessed the prevalence and mortality risk associated with elevated levels of cTnT or cTnI following elective PCI.

The research team conducted electronic and manual searches of all published studies reporting on the prognostic impact of cTnT or cTnI elevation following elective angioplasty. Twenty-two studies, published between 1998 and 2009, were identified and included 22
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Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

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