Navigation Links
Elevated levels of sodium blunt response to stress, study shows
Date:4/5/2011

CINCINNATIAll those salty snacks available at the local tavern might be doing more than increasing your thirst: They could also play a role in suppressing social anxiety.

New research from the University of Cincinnati (UC) shows that elevated levels of sodium blunt the body's natural responses to stress by inhibiting stress hormones that would otherwise be activated in stressful situations. These hormones are located along the hypothalamic-pituitary-adrenal (HPA) axis, which controls reactions to stress.

The research is reported in the April 6, 2011, issue of The Journal of Neuroscience, the official journal of the Society for Neuroscience.

"We're calling this the Watering Hole Effect," says Eric Krause, PhD, a research assistant professor in the basic science division of UC's department of psychiatry and behavioral neuroscience and first author of the study. "When you're thirsty, you have to overcome some amount of fear and anxiety to approach a communal water source. And you want to facilitate those interactionsthat way everyone can get to the water source."

Krause and his team dehydrated laboratory rats by giving them sodium chloride, then exposed them to stress. Compared with a control group, the rats that received the sodium chloride secreted fewer stress hormones and also displayed a reduced cardiovascular response to stress.

"Their blood pressure and heart rate did not go up as much in response to stress as the control group's, and they returned to resting levels more quickly," says Krause.

"Also, in a social interaction paradigm with two rats interacting, we found them to be more interactive and less socially anxious."

Further research, through examination of brain and blood samples from the rats, showed that the same hormones that act on kidneys to compensate for dehydration also act on the brain to regulate responsiveness to stressors and social anxiety.

The elevated sodium level, known as hypernatremia, limited stress responses by suppressing the release of the pro-stress hormone angiotensin II. Conversely, it increased the activity of oxytocin, an anti-stress hormone.

Further research, Krause says, will examine these hormones and neurocircuits to investigate their role in social anxiety disorders and autism, a neurological disorder whose characteristics include social impairment.

"Oxytocin deficiency has been implicated in autism in previous studies," says Krause. "We'd like to investigate the possibility that dysregulation in fluid balance during pregnancy could result in autistic disorders."


'/>"/>

Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. Biologics-naive juvenile idiopathic arthritis patients have elevated risk of cancer
2. Elevated heart rate over time linked to significant risk of death
3. Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
4. Fathers incarceration associated with elevated risks of marijuana and other illegal drug use
5. Common Eye Condition Linked to Elevated Eye Pressure
6. Death of Loved One May Trigger Elevated Heart Rate
7. Up to 8 percent of Canadian children suffer from elevated blood pressure
8. Study of sarcoid-like granulomatous pulmonary disease finds elevated rates in WTC responders
9. Vegans elevated heart risk requires omega-3s and B12
10. Low levels of natural antibodies behind stroke
11. LifeScan Recalls Specific Lots of Consumer and Professional OneTouch(R) SureStep(R) Test Strips Due To Inaccurate Readings at High Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... "As a doctor of lung ... pleural catheters available on the market," said an inventor from Center Valley, Pa. "My ... for the patient." , He developed the patent-pending PLEURAL SAFE-t-STAT CATHETER KIT to offer ...
(Date:7/21/2017)... ... , ... The Ellis Agency, an eastern Georgie provider of insurance management and ... charity event with the goal of bringing in support for epilepsy patients in the ... epilepsy, recently launched a charity campaign of her own by donating her birthday to ...
(Date:7/21/2017)... ... July 21, 2017 , ... Adolfson & Peterson Construction (AP) ... Ramsey County Medical Examiners Facility located in Saint Paul, Minn. A single story, ... scheduled to start in late 2017/early 2018. , Staffed by 20 full-time ...
(Date:7/21/2017)... ... July 21, 2017 , ... Hospital M&A activity slowed in the second quarter ... hospital acquisitions rose to 23 in the second quarter, up 15% from the 20 ... 20 announced deals in the year-ago second quarter. Only four of the transactions disclosed ...
(Date:7/21/2017)... ... July 21, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... of violence and aggression to solve problems and pleads with world leaders to be more ... forces do not bring peace. He says there is a peaceful and positive way to ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... WHIPPANY, N.J. , July 11, 2017  Bayer has ... across eight countries as part of its prestigious Bayer Hemophilia ... Children,s Hospital of Philadelphia and Uniformed ... are among the winners. Grant recipients were announced ... Thrombosis and Hemostasis (ISTH) 2017 Congress, Berlin, Germany ...
(Date:7/10/2017)... July 10, 2017  US medical equipment and supply ... according to Medical Equipment & Supplies: United ... Focus Reports. Continued increases in demand for medical services ... the population and supported by gains in disposable personal ... supplies. New product introductions will also drive sales as ...
(Date:7/6/2017)... ThriveRx, the nutrition division of Diplomat Specialty Infusion Group, is ... nutrition support. To celebrate its anniversary, ThriveRx recently launched a ... new look with improved organization to create the best user experience for ... ... "We,ve made several great strides ...
Breaking Medicine Technology: