Navigation Links
Elevated levels of C-reactive protein appear associated with psychological distress, depression
Date:12/24/2012

CHICAGO Elevated levels of C-reactive protein, a marker of inflammatory disease, appear to be associated with increased risk of psychological distress and depression in the general population of adults in Denmark, according to a report published Online First by Archives of General Psychiatry, a JAMA Network publication.

Depression is one of the leading causes of disability and previous studies suggest that low-grade systemic inflammation may contribute to the development of depression. C-reactive protein (CRP) is a commonly used marker of inflammation, and inflammatory disease is suspected when CRP levels exceed 10 mg/L. Researchers are unclear whether and to what extent elevated CRP levels are associated with psychological distress and depression in the general population, according to the study background.

Marie Kim Wium-Andersen, M.D., of Herlev Hospital and Copenhagen University Hospital, Denmark, and colleagues examined whether elevated plasma levels of CRP were associated with distress and depression. Researchers analyzed CRP levels using data from two general population studies in Copenhagen, which included 73,131 men and women ages 20 to 100 years.

"The main finding of this study consisted of an association of elevated CRP levels with an increased risk for psychological distress and depression in the general population," the authors comment.

Increasing CRP levels were associated with increasing risk for psychological distress and depression in analyses. For self-reported antidepressant use, the odds ratio was 1.38 for CRP levels of 1.01 to 3 mg/L, 2.02 for 3.01 to 10 mg/L, and 2.7 for greater than 10 mg/L compared with 0.01 to 1 mg/L. For prescription of antidepressants, the corresponding odds ratios were 1.08, 1.47 and 1.77, respectively; for hospitalization with depression they were 1.30, 1.84 and 2.27 respectively. Other analyses suggest that increasing CRP levels also were associated with increasing risk for hospitalization with depression, according to the study results.

"More research is needed to establish the direction of the association between CRP and depression because this study and others are primarily cross-sectional. The results also support the initiation of intervention studies to examine whether adding anti-inflammatory drugs to antidepressants for treatment of depression will improve outcome," the authors conclude.
'/>"/>

Contact: Brge Grnne Nordestgaard
Boerge.Nordestgaard@regionh.dk
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. US Drug Watchdog Now Urges All DePuy Pinnacle Hip Implant Recipients To Call Them For The Names Of The Best Law Firms If A Blood Test Indicates Elevated Metal Levels
2. US Drug Watchdog Now Urges All DePuy Pinnacle Hip Implant Recipients To Get A Blood Test For Elevated Levels Of Cobalt Or Chromium and to Call Them If The Levels Are high
3. Miscarriages Tied to Elevated Risk for Heart Conditions
4. Elevated formaldehyde levels found in day care centers
5. Increased dietary fructose linked to elevated uric acid levels and lower liver energy stores
6. Elevated Antibody Levels May Predict Rheumatoid Arthritis Risk
7. Children exposed to 2 phthalates have elevated risk of asthma-related airway inflammation
8. Male Ontario students show declines in fighting; females show elevated bullying and mental distress
9. Nerve growth factors elevated in pancreatic cancer model
10. Study confirms early elevated HIV infection risk in some Step Study participants
11. US Drug Watchdog Now Urges All DePuy Pinnacle Metal On Metal Hip Implant Recipients To Get A Blood Test That Zeros In On Cobalt and Chromium levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... DKT International, one of ... world, is pleased to release their 2015 global impact data. In 2015, DKT ... 14,000 maternal deaths and 3.8 million unsafe abortions across 21 countries worldwide. ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... ranging from medical and pharmaceutical, to food and HVAC facilities. Their knowledgeable staff ... training. , For medical applications, Afrimesure offers a variety of MadgeTech systems ...
(Date:5/25/2016)... Vallarta, Mexico (PRWEB) , ... May 25, 2016 , ... ... surrounding the restorative properties of precious stones to complement its new wellness suites ... over two floors and feature a plethora of special services and insuite amenities, from ...
(Date:5/25/2016)... , ... May 25, 2016 , ... The University of ... and Health Professions. She will lead a team of more than 100 full-time faculty ... begin her role as dean in late August. , Baker comes to USF from ...
(Date:5/25/2016)... ... ... more than fifty years, we've suffered whiplash as each new scientific study seemed to contradict ... nutritional advice – advice that was supposed to keep us healthy and slim. And what ... are considered to be overweight and more than 1 in 3 adults are considered to ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016 Een app die ... zij collectief patiënten kunnen behandelen, hun kennis kunnen delen ... achter de nieuwe en revolutionaire MDLinking App, ontwikkeld door ... vaatchirurg dr. Hans Flu en oncologisch chirurg dr. ... beschikbaar is, wordt op dinsdag 24 mei officieel gepresenteerd ...
(Date:5/23/2016)... May 23, 2016 Transparency Market ... Exocrine Pancreatic Insufficiency Market - Global Industry Analysis, Size, ... According to the report, the exocrine pancreatic insufficiency market ... from 2015 to 2023 to reach US$2.85 Bn by ... condition characterized by the deficiency of the exocrine pancreatic ...
(Date:5/23/2016)... 23, 2016 Non-invasive diagnostic test ... multiple diseases; ,Technology to be presented at Yissum’s booth, ... Research Development Company of the Hebrew University of Jerusalem ... agreement with Aurum Ventures MKI, the technology investment arm of ... new diagnostic approach for early detection of multiple diseases ...
Breaking Medicine Technology: