Navigation Links
Elevated levels of C-reactive protein appear associated with psychological distress, depression
Date:12/24/2012

CHICAGO Elevated levels of C-reactive protein, a marker of inflammatory disease, appear to be associated with increased risk of psychological distress and depression in the general population of adults in Denmark, according to a report published Online First by Archives of General Psychiatry, a JAMA Network publication.

Depression is one of the leading causes of disability and previous studies suggest that low-grade systemic inflammation may contribute to the development of depression. C-reactive protein (CRP) is a commonly used marker of inflammation, and inflammatory disease is suspected when CRP levels exceed 10 mg/L. Researchers are unclear whether and to what extent elevated CRP levels are associated with psychological distress and depression in the general population, according to the study background.

Marie Kim Wium-Andersen, M.D., of Herlev Hospital and Copenhagen University Hospital, Denmark, and colleagues examined whether elevated plasma levels of CRP were associated with distress and depression. Researchers analyzed CRP levels using data from two general population studies in Copenhagen, which included 73,131 men and women ages 20 to 100 years.

"The main finding of this study consisted of an association of elevated CRP levels with an increased risk for psychological distress and depression in the general population," the authors comment.

Increasing CRP levels were associated with increasing risk for psychological distress and depression in analyses. For self-reported antidepressant use, the odds ratio was 1.38 for CRP levels of 1.01 to 3 mg/L, 2.02 for 3.01 to 10 mg/L, and 2.7 for greater than 10 mg/L compared with 0.01 to 1 mg/L. For prescription of antidepressants, the corresponding odds ratios were 1.08, 1.47 and 1.77, respectively; for hospitalization with depression they were 1.30, 1.84 and 2.27 respectively. Other analyses suggest that increasing CRP levels also were associated with increasing risk for hospitalization with depression, according to the study results.

"More research is needed to establish the direction of the association between CRP and depression because this study and others are primarily cross-sectional. The results also support the initiation of intervention studies to examine whether adding anti-inflammatory drugs to antidepressants for treatment of depression will improve outcome," the authors conclude.
'/>"/>

Contact: Brge Grnne Nordestgaard
Boerge.Nordestgaard@regionh.dk
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. US Drug Watchdog Now Urges All DePuy Pinnacle Hip Implant Recipients To Call Them For The Names Of The Best Law Firms If A Blood Test Indicates Elevated Metal Levels
2. US Drug Watchdog Now Urges All DePuy Pinnacle Hip Implant Recipients To Get A Blood Test For Elevated Levels Of Cobalt Or Chromium and to Call Them If The Levels Are high
3. Miscarriages Tied to Elevated Risk for Heart Conditions
4. Elevated formaldehyde levels found in day care centers
5. Increased dietary fructose linked to elevated uric acid levels and lower liver energy stores
6. Elevated Antibody Levels May Predict Rheumatoid Arthritis Risk
7. Children exposed to 2 phthalates have elevated risk of asthma-related airway inflammation
8. Male Ontario students show declines in fighting; females show elevated bullying and mental distress
9. Nerve growth factors elevated in pancreatic cancer model
10. Study confirms early elevated HIV infection risk in some Step Study participants
11. US Drug Watchdog Now Urges All DePuy Pinnacle Metal On Metal Hip Implant Recipients To Get A Blood Test That Zeros In On Cobalt and Chromium levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... FL (PRWEB) , ... February 05, 2016 , ... ... the largest domestic franchisees of Popeyes Louisiana Kitchen restaurants, launched the 14th annual ... awareness for kids and adults with muscular dystrophy, ALS and related diseases that ...
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University President ... have signed a joint enrollment and degree completion agreement. The agreement, which ... baccalaureate degrees at FHU|Dickson. , The agreement allows students to be jointly ...
(Date:2/5/2016)... ... February 05, 2016 , ... US Sports Camps , official operators of ... direct high-performance kids yoga training. ChildLight Yoga Studio is centrally situated in the picturesque ... , ChildLight Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled to ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each ... longer to access the treadmills. It’s a predictable trend. After the excesses of November ... get in shape by joining gyms, starting new walking or running routines, or signing ...
(Date:2/5/2016)... WA (PRWEB) , ... February 05, 2016 , ... ... firm, ranked #3 in the 2015 Best in KLAS: Software & Services for ... The annual Best in KLAS report independently ranks vendor performance by healthcare executives, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)...  LivaNova, PLC, Hersteller des VNS-Therapie ® ... Titel „Epilepsy Around the World" (Epilepsie auf ... gegenüber ein größeres Bewusstsein gefördert werden soll ... Epilepsie auf dem Internationalen Epilepsietag zu einem ... der neuen Infografik sollen wichtige Statistiken zur ...
(Date:2/5/2016)... Calif. , Feb. 5, 2016  Syneron ... global aesthetic device company, announced today that ... Candela North America, is scheduled to participate in ... Healthcare Conference on February 11, 2016 in ... will allow institutional investors to meet with the ...
(Date:2/5/2016)... 5, 2016  Aralez Pharmaceuticals Inc. ("Aralez") today announced ... ("POZEN") and Tribute Pharmaceuticals Canada Inc. ("Tribute") following approval of ... Tribute. The combined company will operate under Aralez Pharmaceuticals ... in Canada , Ireland ... . Under the terms of the Agreement and Plan ...
Breaking Medicine Technology: