Navigation Links
Elevated hormone levels add up to increased breast cancer risk
Date:10/20/2011

Post-menopausal women with high levels of hormones such as estrogen or testosterone are known to have a higher risk of breast cancer. New research published in BioMed Central's open access journal Breast Cancer Research looked at eight different sex and growth hormones and found that the risk of breast cancer increased with the number of elevated hormones - each additional elevated hormone level increased risk by 16%.

Researchers from the Brigham and Women's Hospital and Harvard Medical School used blood samples collected from nurses up to nine years before health information, including their breast cancer status, was recorded. Post-menopausal women who were diagnosed with breast cancer were matched to two controls of a similar age.

The highest levels of circulating estrogens (estrone and estrogen), prolactin, and androgens (testosterone, androstenedione, DHEA, or DHEA-sulfate) were individually associated with between 50 and 200% increase in breast cancer risk. The number of different hormones elevated above normal further increased risk, so that women with one elevated hormone had an increased risk of 10% (compared to normal levels), but the risk for women with five or six elevated hormone levels was doubled, and that for women with seven or eight was tripled. All these risks were slightly higher for women with ER positive disease.

Dr Shelley Tworoger, from Brigham and Women's Hospital, commented that, "Elevated estrogens had the biggest effect on risk, especially for ER positive cancer. However, androgens, and prolactin also contribute to increasing risk of breast cancer. These hormones are known to stimulate the growth of breast cancer cells in the lab and, while androgens can be converted to estrogen in the body, these hormones have also been found to stimulate cancer cell growth in the absence of ER. Our results suggest that models used to assess breast cancer risk could be improved by taking into account multiple sex hormone and growth hormone levels."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Related medicine news :

1. Study finds shingles may be related to elevated risk of multiple sclerosis
2. Elevated protein levels in cardiac muscles could predict mortality following angioplasty
3. Vegans elevated heart risk requires omega-3s and B12
4. Elevated levels of sodium blunt response to stress, study shows
5. Vegans elevated heart risk requires omega-3s and B12
6. Study of sarcoid-like granulomatous pulmonary disease finds elevated rates in WTC responders
7. Up to 8 percent of Canadian children suffer from elevated blood pressure
8. Death of Loved One May Trigger Elevated Heart Rate
9. Common Eye Condition Linked to Elevated Eye Pressure
10. Fathers incarceration associated with elevated risks of marijuana and other illegal drug use
11. Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... , ... March 29, 2017 , ... During the last ... provide free screening colonoscopies to eligible individuals in the local community. , Colon ... but regular screenings can detect colon cancer while it is small, confined and easier ...
(Date:3/29/2017)... FL (PRWEB) , ... March 30, 2017 , ... Grass pollen is the main cause ... allergic to the stuff. The season for grass pollen runs from May to July each ... a hay fever victim to do? HayMax™ allergen barrier balms ( http://www.haymax.us ) provide an ...
(Date:3/29/2017)... ... 2017 , ... Wells Pharmacy Network, a proud A4M Platinum ... World Congress, in Hollywood Florida April 6-8, 2017. , Ben David, CEO of ... in the training of physicians, scientists, and members of the public on anti-aging ...
(Date:3/29/2017)... Horeb, WI (PRWEB) , ... March 29, 2017 , ... ... patients on early orthodontic treatment and accepting new pediatric patients, with or without a ... help young patients have a better orthodontic outcome and experience. When patients receive early ...
(Date:3/29/2017)... ... March 29, 2017 , ... An inventor from Raynham, Mass., ... used in conjunction with my braces always rubbed against the inside of my ... prevent this problem." The O.B.S. was the result of his brainstorming. , This ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... N.Y. , March 29, 2017  BioSpecifics ... originated and continues to develop collagenase based-therapies with ... histolyticum (CCH) marketed as XIAFLEX ®  in the ... management will present a corporate overview at the ... on Wednesday, April 5, 2017 at 8:00 a.m. ...
(Date:3/29/2017)... Research and Markets has announced the addition of the "Italy ... report to their offering. ... Proton Therapy Market in Italy will double by ... currently three proton therapy centers in Italy that ... Italy , the first patients were treated with proton beams in ...
(Date:3/29/2017)... 29, 2017 Research and Markets has ... 2014 - 2025" report to their offering. ... The global ... million by 2025. Increasing geriatric population prone to orthopedic diseases ... navigation systems over the forecast period. Osteoarthritis and osteoporosis are ...
Breaking Medicine Technology: