Navigation Links
Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as anti-inflammatory and analgesic agents. However, they often cause gastrointestinal injury in gastric lesions by inhibiting COX (cyclooxygenase) and detailed mechanism remains unclear. Thus, effective strategies are required to protect the gastrointestinal mucosa.

A research article to be published on February 28, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Choi from Korea Institute of Oriental Medicine investigated the protective effects of acupuncture against NSAID-induced ulceration in a rat model.

In their study, 72 rats were randomly divided into three groups including control (administered with distilled water), ASA group (administered 100 mg/kg ASA) and EA group (administered EA + 100 mg/kg ASA). Each rat was fasted for 18 to 24hours before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured.

They found that the lesion scores of the EA group were significantly lower than those of the NSAID-induced ulceration group. Gastric acidity of NSAID-induced ulceration group and EA group was reduced as compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and NSAID-induced ulceration group, and NO levels were also significantly increased in the EA group as compared to the NSAID-induced ulceration group.

The inducible expression of COX-1 in the early phase and COX-2 in the late phase suggests that EA pretreatment might up-regulate the mucosal defense mechanism. The total NO concentration in the EA group was significantly increased with respect to that of the NSAID-induced ulceration group. The total NO likely protected the gastric mucosa against NSAID-induced toxicity. In conclusion, EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components.

By understanding the time-dependent expression of COX by EA pretreatment, this study may represent a future strategy for acupuncture therapeutic intervention in the treatment of patients with gastritis by Non-steroidal anti-inflammatory drugs.


Contact: Lai-Fu Li
World Journal of Gastroenterology

Related medicine news :

1. Growth factor protects key brain cells in Alzheimers models
2. How the Ear Protects Your Hearing
3. Exercise Protects Black Women From Type 2 Diabetes
4. Gene which protects against lung cancer identified
5. Heartworm Disease Prevention Protects Pets, Wallets
6. Vigorous activity protects against breast cancer
7. Vitamin D protects cells from stress that can lead to cancer
8. Pennsylvania Conference Committee Should Approve Smoke-Free Bill That Covers All Workplaces and Protects All Workers
9. EGFR protects cancer cells from starvation via a kinase-independent mechanism
10. Unexpected role: EGFR protects cancer cells from starving
11. Treating Stomach Infection Early Protects Against Cancer
Post Your Comments:
(Date:11/30/2015)... ... 2015 , ... MOSI recently added two state-of-the-art augmented reality (AR) experiences from ... to their collection of interactive exhibits within the Kids In Charge! building. In collaboration ... to get closer than ever to a range of animals as they drink, sleep ...
(Date:11/30/2015)... ... 2015 , ... The world of hair transplants and restoration is filled with ... and procedures have been in use for many years and are among the most ... M.D. has utilized many of these methods over the years, he also keeps an ...
(Date:11/30/2015)... ... 30, 2015 , ... On Saturday, October 24th, 2015, at the Mill Race ... event, a 5K walk known as “Making Strides Against Breast Cancer”. Patients and staff ... also located in Battle Creek, joined in for this campaign that sought to raise ...
(Date:11/30/2015)... ... 2015 , ... The presidential race normally deals with political issues of national ... national news story when Donald Trump makes disparaging remarks about Hillary Clinton’s hairstyle? It ... anyone wants to admit when it comes to how people are viewed by others. ...
(Date:11/30/2015)... , ... November 30, 2015 , ... According to an ... Decker made a brave but slightly unusual choice to show her Instagram followers that ... pre-pregnancy form may have been pre-mature. Saying that she didn’t “want to mislead any ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 2015 --> --> ... Market by Product (Soft Tissue, All Tissue, Dental Welding Lasers), ... and Geography - Global Forecast to 2020", published by MarketsandMarkets, ... a CAGR of 5.2% during the forecast period from 2015 ... and 62 Figures spread through 167 P ages and ...
(Date:11/30/2015)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ), a clinical-stage ... delivery systems, announced today it has signed definitive licensing ... of Technologies Co., Ltd. ("HTIT") for exclusive rights to ... China , Hong Kong ... signed at the Israel Knesset (Parliament). ...
(Date:11/30/2015)... , Nov. 30, 2015   Nuance Communications, Inc. ... National Decision Support Company (NDSC) today jointly announced ... collaboration capabilities that utilize the American College of Radiology,s ... provider organizations to comply with current and emerging ... --> By combining clinical decision support, ...
Breaking Medicine Technology: