Navigation Links
Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats
Date:3/3/2009

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as anti-inflammatory and analgesic agents. However, they often cause gastrointestinal injury in gastric lesions by inhibiting COX (cyclooxygenase) and detailed mechanism remains unclear. Thus, effective strategies are required to protect the gastrointestinal mucosa.

A research article to be published on February 28, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Choi from Korea Institute of Oriental Medicine investigated the protective effects of acupuncture against NSAID-induced ulceration in a rat model.

In their study, 72 rats were randomly divided into three groups including control (administered with distilled water), ASA group (administered 100 mg/kg ASA) and EA group (administered EA + 100 mg/kg ASA). Each rat was fasted for 18 to 24hours before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured.

They found that the lesion scores of the EA group were significantly lower than those of the NSAID-induced ulceration group. Gastric acidity of NSAID-induced ulceration group and EA group was reduced as compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and NSAID-induced ulceration group, and NO levels were also significantly increased in the EA group as compared to the NSAID-induced ulceration group.

The inducible expression of COX-1 in the early phase and COX-2 in the late phase suggests that EA pretreatment might up-regulate the mucosal defense mechanism. The total NO concentration in the EA group was significantly increased with respect to that of the NSAID-induced ulceration group. The total NO likely protected the gastric mucosa against NSAID-induced toxicity. In conclusion, EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components.

By understanding the time-dependent expression of COX by EA pretreatment, this study may represent a future strategy for acupuncture therapeutic intervention in the treatment of patients with gastritis by Non-steroidal anti-inflammatory drugs.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Growth factor protects key brain cells in Alzheimers models
2. How the Ear Protects Your Hearing
3. Exercise Protects Black Women From Type 2 Diabetes
4. Gene which protects against lung cancer identified
5. Heartworm Disease Prevention Protects Pets, Wallets
6. Vigorous activity protects against breast cancer
7. Vitamin D protects cells from stress that can lead to cancer
8. Pennsylvania Conference Committee Should Approve Smoke-Free Bill That Covers All Workplaces and Protects All Workers
9. EGFR protects cancer cells from starvation via a kinase-independent mechanism
10. Unexpected role: EGFR protects cancer cells from starving
11. Treating Stomach Infection Early Protects Against Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... this installment is bolstered by inspiring human interest stories, courtesy of leaders in ... trends and tech within the industry, from leading advocates and associations—namely Jones & ...
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports ... Yellen and company to wait until March 2017 for an interest rate increase, according ... Robinson College of Business. , “The Federal Open Market Committee (FOMC) dot charts are ...
(Date:5/26/2016)... ... May 26, 2016 , ... Intalere, the healthcare ... suppliers for its inaugural Member Conference at the Paris Hotel in Las Vegas, ... operational health of America’s healthcare providers. , The conference was highlighted by the ...
(Date:5/26/2016)... ... ... The Woodlands at John Knox Village , Florida’s first Life Plan ... and healing, celebrated its grand opening, today. The Woodlands at John Knox Village is ... Staff. , “This is an incredibly fulfilling time for John Knox Village as we ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... solutions for drugs, biologics, consumer health and global clinical supply services, today announced ... to support the company’s continued investment and strategic growth plans in the Asia ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior ... executive officer, today. In his new role, Marziani will lead the company,s business development ... professionals to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... KONG , May 24, 2016 ... stent de doble terapia del mundo, introduce catéteres ... arteriovenosa. OrbusNeich, una compañía global especializada ... las vidas, ha expandido su cartera incluyendo productos ... balón JADE™ y Scoreflex™ PTA son los dispositivos ...
(Date:5/24/2016)... -- Open Access Journal Focusing on ... Elsevier , a world-leading provider of scientific, technical ... launch of Clinical Neurophysiology Practice ... clinical practice issues in clinical neurophysiology. The journal will ... and didactic reviews. It is an official journal of ...
Breaking Medicine Technology: