Navigation Links
Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats
Date:3/3/2009

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as anti-inflammatory and analgesic agents. However, they often cause gastrointestinal injury in gastric lesions by inhibiting COX (cyclooxygenase) and detailed mechanism remains unclear. Thus, effective strategies are required to protect the gastrointestinal mucosa.

A research article to be published on February 28, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Choi from Korea Institute of Oriental Medicine investigated the protective effects of acupuncture against NSAID-induced ulceration in a rat model.

In their study, 72 rats were randomly divided into three groups including control (administered with distilled water), ASA group (administered 100 mg/kg ASA) and EA group (administered EA + 100 mg/kg ASA). Each rat was fasted for 18 to 24hours before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured.

They found that the lesion scores of the EA group were significantly lower than those of the NSAID-induced ulceration group. Gastric acidity of NSAID-induced ulceration group and EA group was reduced as compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and NSAID-induced ulceration group, and NO levels were also significantly increased in the EA group as compared to the NSAID-induced ulceration group.

The inducible expression of COX-1 in the early phase and COX-2 in the late phase suggests that EA pretreatment might up-regulate the mucosal defense mechanism. The total NO concentration in the EA group was significantly increased with respect to that of the NSAID-induced ulceration group. The total NO likely protected the gastric mucosa against NSAID-induced toxicity. In conclusion, EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components.

By understanding the time-dependent expression of COX by EA pretreatment, this study may represent a future strategy for acupuncture therapeutic intervention in the treatment of patients with gastritis by Non-steroidal anti-inflammatory drugs.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Growth factor protects key brain cells in Alzheimers models
2. How the Ear Protects Your Hearing
3. Exercise Protects Black Women From Type 2 Diabetes
4. Gene which protects against lung cancer identified
5. Heartworm Disease Prevention Protects Pets, Wallets
6. Vigorous activity protects against breast cancer
7. Vitamin D protects cells from stress that can lead to cancer
8. Pennsylvania Conference Committee Should Approve Smoke-Free Bill That Covers All Workplaces and Protects All Workers
9. EGFR protects cancer cells from starvation via a kinase-independent mechanism
10. Unexpected role: EGFR protects cancer cells from starving
11. Treating Stomach Infection Early Protects Against Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... ... , ... The Citadel’s new Swain Department of Nursing , along with ... Ph.D. Joseph was engaged by the college as a consultant to help build the ... a nation-wide search, she was selected to head the department as nurse administrator, assuming ...
(Date:2/19/2017)... , ... February 19, 2017 , ... ... to result in better care, and MEDfx and the Delaware Health Information Network ... Delaware. , As the nation’s first state-wide health information exchange, DHIN stores and ...
(Date:2/18/2017)... , ... February 17, 2017 , ... ... source of disruptive innovation in the industry, according to the recent NEJM Catalyst ... based on surveys of the NEJM Catalyst Insights Council, a qualified group of ...
(Date:2/18/2017)... ... 2017 , ... Park Cities Pet Sitter President, Joette White, has been featured ... network. The episode, which was posted this week, features a 30-minute interview of ... Park Cities Pet Sitter’s being awarded the 2017 National Association of Professional Pet Sitter’s ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... Smiles by ... Shopping Center in Davidson, NC. Dr. Brian Seese leads the practice as a skilled ... services under one roof. Smiles by Seese serves patients of all ages with excellence ...
Breaking Medicine News(10 mins):
(Date:2/19/2017)... Fla. , Feb. 19, 2017  nThrive™, ... revenue cycle portfolio and thought leadership at the ... receiving a category leader award from KLAS. ... panel discussion focused on how market trends shape ... -  particularly a sophisticated, comprehensive Patient Access solution. ...
(Date:2/18/2017)... , Feb. 17, 2017   Parker ... protecting the rights of victims injured by medical ... regulators to call for better reporting. Congress required ... Safety concerns involving power morcellators and duodenoscopes ... to investigate how hospitals report injuries and deaths ...
(Date:2/17/2017)... Cryoablation, Electrical, Endometrial Hydrothermal, Laser/Light, Microwave, Radiofrequency, Ultrasound, Cardiovascular, ... is expected to grow at a CAGR of 9.4% from 2017-2022 ... grow at a CAGR of 9.5% from 2017 to 2027. The ... ... will benefit you Read on to discover how you can ...
Breaking Medicine Technology: