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Elderly with depression, mild cognitive impairment more vulnerable to accelerated brain aging
Date:8/7/2014

ues associated with Alzheimer's disease.

The MCI group was more likely to have differences in the biologic activity of 24 proteins that are involved in the regulation of immune and inflammatory pathways, intracellular signaling, cell survival, and protein and lipid balance.

Brain scans revealed a greater propensity for cerebrovascular disease for example, small strokes in the MCI group, but there was no difference in the amount of beta-amyloid deposition.

"If you take these results altogether, they suggest that people with depression and cognitive impairment may be more vulnerable to accelerated brain aging, which in turn puts them at risk for developing dementia," Dr. Butters said. "Ultimately, if we can understand what happens in the brain when people are depressed and suffer cognitive impairment, we can then develop strategies to slow or perhaps stop the impairment from progressing to dementia."

Next steps include assessing the protein panel in older people with normal cognitive function who have not experienced depression.


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Contact: Gloria Kreps
Phone: 412-586-9764
E-mail: KrepsGA@upmc.edu

Contact: Rick Pietzak
Phone: 412-864-4151
E-mail: PietzakR@upmc.edu
Source:Eurekalert


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