Navigation Links
Elderly with depression, mild cognitive impairment more vulnerable to accelerated brain aging
Date:8/7/2014

PITTSBURGH, Aug. 7, 2014 People who develop depression and mild cognitive impairment (MCI) after age 65 are more likely to have biological and brain imaging markers that reflect a greater vulnerability for accelerated brain aging, according to a study conducted by researchers at the University of Pittsburgh School of Medicine. The findings were published online in Molecular Psychiatry.

Older adults with major depression have double the risk of developing dementia in the future compared with those who have never had the mood disorder, said senior investigator Meryl A. Butters, Ph.D., associate professor of psychiatry, Pitt School of Medicine. But there's no clear explanation for why a treatable mood disorder like depression leads to increased risk for dementia, a progressive brain disease. Until now, most studies have examined only one or two biomarkers to get at this question.

"Our study represents a significant advance because it provides a more comprehensive and integrated view of the neurobiological changes related to mild cognitive impairment in late-life," she said. "Better understanding of the neurobiology of cognitive impairment in depression can provide new targets for developing more specific treatments, not only for its prevention and treatment, but also for its down-stream negative outcomes, including the development of dementia and related disorders."

The team collected blood samples from 80 older adults in remission after being treated for major depression, 36 of whom had MCI and 44 with normal cognitive function. Their blood was tested for 242 proteins involved in biologic pathways associated with cancer, cardiovascular diseases, and metabolic disorders as well as psychiatric and neurodegenerative disorders. The researchers also performed PET and MRI brain scans on the participants to look for indicators of cerebrovascular disease, brain atrophy or shrinkage, and beta-amyloid, which is the protein that makes up the brain plaq
'/>"/>

Contact: Gloria Kreps
Phone: 412-586-9764
E-mail: KrepsGA@upmc.edu

Contact: Rick Pietzak
Phone: 412-864-4151
E-mail: PietzakR@upmc.edu
Source:Eurekalert


Page: 1 2

Related medicine news :

1. Locked, loaded & feeling low: Dangers of gun ownership in the elderly
2. Carnegie Mellon researchers discover social integration improves lung function in elderly
3. Being Sardinian puts a smile on the face of the elderly
4. EORTC and SIOG update expert opinion on management of elderly patients with NSCLC
5. Internet use can help ward off depression among elderly
6. Experts question routine mammograms in elderly
7. Surgery after major stroke also improves survival odds in elderly patients
8. Better continuity of care for elderly pataients cuts costs and complications, study finds
9. Dance and virtual reality: A promising treatment for urinary incontinence in elderly women
10. Mid America Professional Group, PC and DENTCA, Inc. Renew Commitment to Providing High Quality Dentures to America’s Elderly Population
11. The Steady Pour Helps Elderly/Physically Disabled People - Invented by InventHelp Client (SLC-1022)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... October 30, 2014 Don Allred Insurance, ... health insurance plans for North Carolina residents, is excited ... in Burlington’s Holly Hill Mall. The new branch has ... already helping customers through all facets of the insurance ... Allred Insurance spokesman Scott Allred couldn’t be happier with ...
(Date:10/30/2014)... 30, 2014 Five months after their ... Street LLC announces new branding and a website to ... . After David Mepham’s promotion to name partner earlier ... website to include Mepham’s name and better reflect their ... mediation firm, the decision to implement new branding reflects ...
(Date:10/30/2014)... N.C. (PRWEB) October 30, 2014 Paramount ... health care, is increasing efforts to help people save ... expenses continue to increase for prescription drugs in the ... valuable savings and resources to bridge the relationship between ... One of the biggest challenges people face today with ...
(Date:10/30/2014)... HealthDay Reporter , WEDNESDAY, Oct. 29, ... prostate cancer who also have certain heart problems may increase ... study suggests. , , The therapy in question is called androgen ... levels of male hormones to prevent the growth of cancer ... this hormone therapy was linked to triple the risk of ...
(Date:10/30/2014)... By Dennis Thompson ... -- The Ebola outbreak in Liberia -- one of three ... slowing, World Health Organization officials said Wednesday. Dr. Bruce ... in the number of burials in Liberia and no increase ... the global push to tame the epidemic may be making ...
Breaking Medicine News(10 mins):Health News:Allred Insurance Satellite Office Grand Opening 2Health News:Hodgkinson Street Mepham Rebrands 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3
... , PORTLAND, Ore., July 29 While Congress debates ... its work to engage consumers to transform health care from the ... System - Engaging Consumers to Create Value-Driven Health Care," designed for ... and from Healthcare Marketing Report,s Annual Healthcare Advertising Awards. An interactive ...
... Death risk only 0.3 percent, chances of serious complications ... For those considering bariatric surgery to combat significant obesity, ... be much lower than what has previously been reported. ... surgery and laparoscopic adjustable gastric banding (lap-band surgery), found ...
... , , ST. LOUIS, July 29 ... quarter net income from continuing operations of $192.0 million, or $0.74 ... related to the previously announced acquisition of WellPoint,s pharmacy benefit management ... $0.76 for the same period last year. These earnings for the ...
... , , , SAN DIEGO, ... medical device company focused on developing products for minimally disruptive surgical ... of Finance and Investor Relations, is scheduled to present at the ... Hotel in New York, New York, on Wednesday, August 5, 2009, ...
... , COLUMBUS, Ohio, July 29 Roxane ... Drug Application (ANDA) for Risperidone Oral Solution, 1mg/mL by the ... 30mL bottles for immediate shipment to wholesalers and pharmacies nationwide. ... 1mg/mL are AA rated to RISPERDAL(R) (risperidone) oral solution. Annual ...
... , WASHINGTON, July 29 Three of the ... by supporting the Obama health-care plan, which would foster a ... sex education, euthanasia and eugenics. , , ... , , Catholic Charities USA, the Society ...
Cached Medicine News:Health News:Regence Wins Awards for Consumer Appeal to Transform Health Care 2Health News:Study Finds Weight-Loss Surgery Safer Than Thought 2Health News:Study Finds Weight-Loss Surgery Safer Than Thought 3Health News:Express Scripts Reports Strong Second Quarter Earnings 2Health News:Express Scripts Reports Strong Second Quarter Earnings 3Health News:Express Scripts Reports Strong Second Quarter Earnings 4Health News:Express Scripts Reports Strong Second Quarter Earnings 5Health News:Express Scripts Reports Strong Second Quarter Earnings 6Health News:Express Scripts Reports Strong Second Quarter Earnings 7Health News:Express Scripts Reports Strong Second Quarter Earnings 8Health News:Express Scripts Reports Strong Second Quarter Earnings 9Health News:Express Scripts Reports Strong Second Quarter Earnings 10Health News:Express Scripts Reports Strong Second Quarter Earnings 11Health News:Express Scripts Reports Strong Second Quarter Earnings 12Health News:Express Scripts Reports Strong Second Quarter Earnings 13Health News:Express Scripts Reports Strong Second Quarter Earnings 14Health News:NuVasive to Present at the BMO Capital Markets 9th Annual Focus on Healthcare Conference 2Health News:NuVasive to Present at the BMO Capital Markets 9th Annual Focus on Healthcare Conference 3Health News:Roxane Laboratories, Inc. Announces the Launch of Risperidone Oral Solution 1mg/mL 2Health News:Catholic Charities, Vincent De Paul Society Supporting Abortion-Providing Healthcare Plan, Says ALL 2
(Date:10/30/2014)... 2014 Boston Scientific Corporation (NYSE: ... Credit Suisse Annual Healthcare Conference on Tuesday, November 11, ... Dan Brennan , executive vice president and chief financial ... at approximately 8:00 a.m. PT followed by a question ... the presentation and question and answer session will be ...
(Date:10/30/2014)... , Oct. 30, 2014 CVS Health (NYSE: ... new clinical affiliations with three leading regional health systems to ... The collaborating health systems include Baptist Health System in ... which include Commonwealth Health in Pennsylvania , ... Arizona , and Tennova Healthcare in Tennessee ...
(Date:10/30/2014)... --  BioLife Solutions , Inc. (NASDAQ: BLFS ... clinical grade hypothermic storage and cryopreservation ... for cells and tissues, today announced today that ... released on Thursday, November 6, 2014, and that the ... at 1:30 p.m. PST that afternoon. Management will provide ...
Breaking Medicine Technology:Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 4BioLife Solutions to Report Financial Results for Third Quarter 2014 and Provide Business Update on November 6, 2014 2
... 2 adjustable belt buckle. You adjust once and ... off your shoulders. And now theres our Lady ... anatomy. ,For additional back support try one of ... on the vertebrae and help lift the apron ...
The Easy Wrap Apron is now available with an attached Thyroid Collar. The Thyroid Collar is held on with velcro so it adjusts to fully protect the neck. This Apron with Collar is available in 5mm lea...
The major innovation in posterior stabilized (PS) knee design. Improve patellofemoral kinematics. Reduce wear rate potential. Increase resistance to posterior tibial dislocation. Achieve at least 120...
StelKast's Proven™ Knee System is a long term high quality solution based on a clinically proven and successful design....
Medicine Products: