Navigation Links
Elderly immune system needs a boost
Date:10/8/2009

Elderly cancer patients need a combination of treatments tailor-made to their specific needs to successfully combat the disease. The challenge is to boost their immune response to cancer vaccines, because like the rest of our organs, our immune system ages and gradually becomes less efficient as we get older. Dr. Joseph Lustgarten, from the Mayo Clinic College of Medicine in the US, reviews the effects of aging on the immune system and strategies used to activate a stronger antitumor immune response in the elderly, including genetic modifications in animal models. His findings (1) have just been published in the latest issue of Springer's journal Cancer Immunology, Immunotherapy.

Aging of the immune system coincides with higher rates of cancer in the elderly. There is a wealth of research on the effects of harnessing the power of the body's own immune defences to recognize and destroy tumors (immunotherapy), yet very little of this work takes into account the effects of aging on the immune system. Older individuals do not respond to vaccine therapy as well as younger adults.

Dr. Lustgarten's paper summarizes some of the defects found in the old immune system which affect antitumor responses; strategies used to improve the efficiency of older people's immune response; and the use of animal models to identify how it might be possible to manipulate the old immune system, for more effective immunotherapeutic interventions in older patients.

Vaccination strategies that effectively stimulate antitumor immune responses in both younger and older patients are dependent on combining different therapies. The therapies must keep the balance between activating a safe and effective antitumor immune response and inducing an autoimmune reaction.

Dr Lustgarten concludes: "The immune system of the elderly is very different from the young and it is difficult to extrapolate results obtained in the young, for use in the old. Our job in the next few years is to figure out how to robust the old immune system by understanding, at a molecular level, its intrinsic defects to properly stimulate antitumor responses. Only then can we successfully customize tumor vaccines to be effective for the treatment of tumors in the old."


'/>"/>

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer
Source:Eurekalert

Related medicine news :

1. Half-million low-income elderly affected by sweeping cuts to state safety net
2. Study shows that elderly women sleep better than they think, men sleep worse
3. Impaired kidney function linked to cognitive decline in elderly
4. Insulin boost restores muscle growth in elderly
5. Waist-Hip Ratio Good Gauge of Obesity in Elderly, Study Shows
6. Endoscopy within 24 hours shows better outcomes in elderly with peptic ulcer bleeding
7. Good News for Elderly: Happiness Keeps Growing
8. Leading U.S. Expert Offers Ten Warning Signs and Symptoms of Mental Health Problems in Elderly
9. Fox Chase finds all-biologic regimen efficacious and well-tolerated in elderly lung cancer patients
10. Renaissance Grants $3,000 to the Florida Dental Association to Present Oral Health Workshops for the Vulnerable Elderly
11. Caring for Elderly Parents Is Tougher During Hard Times
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... The president released a FY 2017 budget request ... shift more of the cost burden to military beneficiaries. , MOAA’s president, retired ... defense budget as including limited quantifiable benefit fixes mixed with numerous beneficiary fee hikes. ...
(Date:2/11/2016)... ... 2016 , ... In a new paper published in the ... Rod J. Rohrich, and colleagues, examine and underscore the importance of upper lateral ... when addressing this vital area. , The upper lateral cartilage in rhinoplasty, refers ...
(Date:2/11/2016)... ... February 11, 2016 , ... PharmMD CEO Robert ... will focus on contract negotiations, corporate strategy and healthcare data law. Additional responsibilities ... practices in data breaches for the Part D Star Rating improvement and Medication ...
(Date:2/11/2016)... ... February 11, 2016 , ... Talix today announced ... , will be presenting at the 2016 HIMSS Annual Conference & Exhibition, taking ... During his session, “ Coding for Care: Using Data Analytics for Risk Adjustment ...
(Date:2/11/2016)... ... February 11, 2016 , ... Be Well Medical ... in the heart of Old Town at 108 South Columbus St, Suite 201, Alexandria, ... highest level of medical care in the convenience of their homes, offices or at ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016 Transformational M&A achieved through NPS ... --> Transformational M&A achieved through NPS and Dyax ... Transformational M&A achieved through NPS and Dyax acquisitions ... for future growth with most robust pipeline in Shire ... future growth with most robust pipeline in Shire , ...
(Date:2/11/2016)... 11, 2016  AbbVie, a global biopharmaceutical company, ... designed to provide financial support for exceptional students ... higher education goals. Fifteen scholars will be selected ... year. The AbbVie Rheumatology Scholarship is currently accepting ... president, corporate social responsibility, brand and communications, AbbVie. ...
(Date:2/11/2016)... Exactus Pharmacy Solutions, a WellCare (NYSE: ... care for those suffering from long-term, life-threatening or ... Specialty Pharmacy Accreditation from URAC, an independent, nonprofit ... care quality through accreditation, education and measurement. ... URAC accreditation process demonstrates a commitment to quality ...
Breaking Medicine Technology: