Navigation Links
Einstein scientists treat cancer as an infectious disease -- with promising results
Date:10/30/2007

(BRONX, NY) Researchers at the Albert Einstein College of Medicine of Yeshiva University have shown for the first time that cancers can be successfully treated by targeting the viruses that cause them. The findings, published in the October 31 issue of PloS One, also raise the possibility of preventing cancer by destroying virus-infected cells before they turn cancerous.

The Einstein researchers used a technique called radioimmunotherapy, in which radioisotopes are piggybacked onto antibodies. Once these precision-made molecules are injected into the body, the antibodies home in on a specific protein targetand the radioisotope warhead destroys the cell to which the protein is attached. In this research the targets were viral antigens: proteins expressed by virus-infected cells that can cause those cells to multiply out of control and become cancerous.

Nearly 20 percent of human cancers worldwide are caused by preexisting virus infections. Prime examples are liver cancer (caused by hepatitis B and C viruses), cervical cancer (caused by human papillomaviruses) and certain lymphomas (caused by the Epstein-Barr virus). But while antigens on the surface of cells are susceptible to attack by antibodies, the viral antigens associated with cancers typically lurk inside infected cells, so scientists had assumed that antibodies couldnt reach them.

We had a hunch that rapidly growing tumors can outgrow their blood supply, resulting in dead tumor cells that might spill their viral antigens amongst the living cancer cells, says Dr. Arturo Casadevall, Forchheimer Professor and Chair of Microbiology & Immunology at Einstein and co-senior author of the study. So we hoped that by injecting antibodies hitched to isotopes into the blood that theyd be carried deep into the tumor mass and would latch onto these now-exposed antigens. Then the blast of radiation emitted by the radioisotope would destroy the live tumor cells nearby.

Testing their theory in mice, the Einstein researchers attached the radioisotope rhenium-18 to monoclonal antibodies made against E6, a viral antigen expressed by virtually all cervical-cancer cells. Similarly, they prepared radioimmunotherapy for liver cancer by attaching rhenium-18 to monoclonal antibodies against HBx, a viral antigen made by liver-cancer cells. Then, mice bearing human cervical-cancer tumors or human liver tumors were treated with the appropriate therapy.

For both types of cancer, the radioimmunotherapy resulted in significant slowing of tumor growth compared with tumors in untreated mice. For the cervical-cancer mice, the therapy not only stopped the growth of tumors but even caused them to regress.

Radioimmunotherapy not only worked against these cancers, but in addition the radioactivity was confined entirely to the tumor masses, leaving healthy tissues undamaged,says Dr. Ekaterina Dadachova, Associate Professor of Nuclear Medicine and of Microbiology & Immunology at Einstein and the studys other senior co-author.

During her seven years at Einstein, Dr. Dadachova has pioneered the use of radioimmunotherapy against infection-related diseases. In a series of animal studies beginning in 2001, she successfully used radioimmunotherapy against the major fungal pathogen Cryptococcus neoformans and against a streptococcal bacterium responsible for pneumonia. Last year, she and her colleagues showed that radioimmunotherapy could help to halt HIV infection by targeting one of several viral proteins displayed on the surface of HIV-infected cells.

Virus-associated cancers account for some 1.3 million cancer cases each year, so the need for new strategies in treating them is obvious and urgent, says Dr. Dadachova. Our study has shown in principle that radioimmunotherapy can help in treating cancers caused by virusesand, just as exciting, the approach also holds promise for cancer prevention. In people chronically infected with hepatitis B or C, human papillomaviruses, or other viruses known to cause cancer, radioimmunotherapy could potentially eliminate virus-infected cells before theyre able to transform into cancer cells.


'/>"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Will Your Baby Grow Up To Be A Future Einstein ?
2. Malaria Truths Discovered By Einstein Researchers
3. Einsteins Tea Leaves Inspire New Blood Separation Technique
4. Nobel Prize for Medicine shared by Three scientists
5. Scientists plan human cloning clinic in the United States
6. Scientists crack mechanism of Leptin-Obesity Hormone
7. Scientists use plant hormones to fight cancer
8. American scientists alter gene makeup of babies
9. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
10. Scientists found ancient Human Germ Killer
11. Scientists locate key hormone involved in appetite control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2017)... (PRWEB) , ... August 24, 2017 , ... ... supplements that help people improve all aspects of their health and wellness, has ... , The step represents a component of Natural Subsistence’s aggressive marketing strategy in ...
(Date:8/24/2017)... ... August 24, 2017 , ... AudioEducator is the country’s top ... coming months, AudioEducator has lined up several training sessions on ICD-10 coding ... experts, these healthcare training conferences are designed to update providers with all the ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... President Business Development and Sector Growth. Mr. Smith joins other recent high-profile hires ... , Mr. Smith’s healthcare career began in 1993, helping physician practices and hospitals ...
(Date:8/23/2017)... ... ... The Stevie® Awards have announced the winners of the Best of the IBA Awards in ... , Nominees in the 2017 IBAs were not able to apply for the Best of ... number of awards won in the IBAs with a Gold Stevie win counting for three ...
(Date:8/23/2017)... , ... August 23, 2017 , ... ... MD , has returned home to Indiana, and is now seeing patients at ... board-eligible ophthalmologist that specializes in the diagnosis and treatment of eye disease, medical ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced financial ... unless otherwise noted, are to the quarter ended June 30, ... 2017 Highlights include: Revenue of $1,126 ... Total prescriptions dispensed of 220,000, compared to 241,000 ... Gross profit per prescription dispensed of $371, ...
(Date:8/4/2017)... , Aug. 4, 2017 The search ... shortly after a physician/patient consult has long been the ... was a notable focus of the largest meeting of ... according to healthcare market research firm Kalorama Information.  The ... testing (POCT) offerings or related supplies and software were ...
(Date:8/3/2017)... Aug. 3, 2017  Opioid addiction and other drugs ... healthcare costs and threatening outcomes, were problems taken on ... IVD industry that support them, met this week. This ... said that drugs of abuse, procalcitonin and acute kidney ... the organization,s 69th meeting in San Diego, ...
Breaking Medicine Technology: