Navigation Links
Einstein scientists propose new theory of autism
Date:4/1/2009

y brain system involved both in producing fever and controlling behavior," says co-author Dominick P. Purpura, M.D., dean emeritus and distinguished professor of neuroscience at Einstein.

The locus coeruleus has widespread connections to brain regions that process sensory information. It secretes most of the brain's noradrenaline, a neurotransmitter that plays a key role in arousal mechanisms, such as the "fight or flight" response. It is also involved in a variety of complex behaviors, such as attentional focusing (the ability to concentrate attention on environmental cues relevant to the task in hand, or to switch attention from one task to another). Poor attentional focusing is a defining characteristic of autism.

"What is unique about the locus coeruleus is that it activates almost all higher-order brain centers that are involved in complex cognitive tasks," says Dr. Mehler.

Drs. Purpura and Mehler hypothesize that in autism, the LC-NA system is dysregulated by the interplay of environment, genetic, and epigenetic factors (chemical substances both within as well as outside the genome that regulate the expression of genes). They believe that stress plays a central role in dysregulation of the LC-NA system, especially in the latter stages of prenatal development when the fetal brain is particularly vulnerable.

As evidence, the researchers point to a 2008 study, published in the Journal of Autism and Developmental Disorders, that found a higher incidence of autism among children whose mothers had been exposed to hurricanes and tropical storms during pregnancy. Maternal exposure to severe storms at mid-gestation resulted in the highest prevalence of autism.

Drs. Purpura and Mehler believe that, in autistic children, fever stimulates the LC-NA system, temporarily restoring its normal regulatory function. "This could not happen if autism was caused by a lesion or some structural abnormality of the brain," says Dr. Pur
'/>"/>

Contact: Deirdre Branley
dbranley@aecom.yu.edu
718-430-2923
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Einstein researchers discover protein that contributes to cancer spread
2. Lt. Col. Weinstein, New Book: Universal Health Care Will Not Work Unless
3. Senator Dianne Feinstein Denounces Prop 8
4. Feinstein Institute: Researching a Family Tree of Autoimmune Disorders
5. Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
6. Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter
7. NIH awards Einstein College of Medicine & Montefiore Medical Center $22M grant
8. Einstein-Montefiore Center for AIDS Research receives $8.5M award from NIH
9. The Feinstein to collaborate with Swedens Karolinska Institute
10. Pioneering Heart Surgeon, Robert E. Michler, M.D., Appointed Chair of Surgery and Surgeon-in-Chief at Einstein and at Montefiore Medical Center
11. Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... Columbus, OH (PRWEB) November 23, 2014 ... Schulte LLC on behalf of farmers and agribusinesses that ... Inc.’s attempts to commercialize Agrisure Viptera and Agrisure Duracade, ... have not been approved for sale in China. According ... caused China to virtually ban U.S. corn imports. Because ...
(Date:11/23/2014)... 2014 BambooFlooringChina.com , the world’s leader ... strand woven bamboo flooring collection. Now, the business is ... company’s CEO, the promotion is valid until Dec. 20, 2014. ... a smooth and dust-free surface, which makes it very easy ... industry, the company wants to make its website the best ...
(Date:11/22/2014)... SC (PRWEB) November 23, 2014 Every ... to their communities. AlignLife experience rapid growth in the ... a very unique opportunity. AlignLife of Simpsonville ... AlignLife offices for their first annual Toy Drive. These ... charity they would support with this year's toy drive. ...
(Date:11/22/2014)... 2014 Cancer researchers in New York ... intercellular communication tunnels and the growth and spread of ... on the Surviving Mesothelioma website. , Doctors ... of Minnesota have just released their study on tunneling ... between cells. They found that mesothelioma cells ...
(Date:11/22/2014)... Recently, UWDress.com, a successful wedding dress shop, ... attire in order to prepare for the wedding season. ... 70% off. , UWDress.com is a reliable company that ... especially the new items -- formal wedding guest attire. This ... market, including superstar and princess. As one of the leading ...
Breaking Medicine News(10 mins):Health News:Syngenta Lawsuits Being Investigated by Wright & Schulte LLC, Following China’s Rejection of Corn Shipments Tainted with Unapproved GMO Seed 2Health News:Syngenta Lawsuits Being Investigated by Wright & Schulte LLC, Following China’s Rejection of Corn Shipments Tainted with Unapproved GMO Seed 3Health News:Click Strand Woven Bamboo Flooring From Famous Bamboo Flooring Company BambooFlooringChina.com 2Health News:Greenville Area AlignLife Offices Join Together for a Local Toy Drive 2Health News:Study Links Cellular ‘Tunnels’ to Mesothelioma Proliferation, According to Surviving Mesothelioma 2Health News:Formal Wedding Guest Attire Added to UWDress.com 2
... Research Group (MRG) has conducted a detailed analysis of ... for Aesthetics Lasers and Energy Devices 2007 report. ... more women will be receiving cellulite reduction procedures as ... In 2006, 330,000 people in the US received laser ...
... Brain holds clue to understand, diagnose and treat bipolar ... International Conference on Bipolar Disorder.It has ... and treatment of the disease. ,The first ... the Laboratory of Molecular Pathophysiology at the National Institute ...
... Scientists from the University of Bonn have discovered this ... have implications for therapy. In animal experiments, a solution ... reactions of the skin. ,Extracts of the ... remedy against inflammation. At the beginning of the last ...
... Pharmaceutical Research & Development, L.L.C., (J&JPRD) announced that ... to the United States Food and Drug Administration ... for the treatment of nosocomial pneumonia, a pneumonia ... healthcare setting. ,According to the Centers ...
... Jordan a.k.a., Katie Price wants to 'tighten up' her vagina after her ... birth to her daughter this month and is firm to have ... I'm a very small girl and my first son Harvey was a ... suffer from a prolapsed womb after they've had a baby. ...
... developer and manufacturer announced today that over 200 ... the OrthoGlide Medial Knee implant. The OrthoGlide is a ... due to moderate osteoarthritis of the medial compartment of ... increase in the number of orthopedic surgeons interested in ...
Cached Medicine News:Health News:Eliminating Cellulite 2Health News:Novel Markers for the Treatment of Bipolar Disorder 2Health News:Cannabinoids Regulate Inflammation Process 2Health News:Cannabinoids Regulate Inflammation Process 3
(Date:11/21/2014)...  Tandem Diabetes Care ® , Inc. (NASDAQ: ... and manufacturer of the t:slim ® Insulin ... non-profit dedicated to improving diabetes therapy management by ... diabetes data accessibility. This partnership will enable users ... development, to download and access data from their ...
(Date:11/21/2014)... , Nov. 21, 2014  World Hemp Oil, ... low THC, announces they are now offering legal, organic ... Charlotte,s Web type strains grown in medical marijuana states. ... neurological disorders, such as Parkinson,s, MS, and spinal cord ... laws to pass, because imported CBD Oil Is legal ...
(Date:11/21/2014)... SOUTH PLAINFIELD, N.J. , Nov. 21, 2014  PTC ... announce that the 2014 Legend of Technology Award for Vision, ... Peltz , Ph.D., Chief Executive Officer. This award recognizes an ... industry in New Jersey for several ... Legend of Technology Award," stated Stuart Peltz , Ph.D., ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 3PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 3
... prostate and ... colorectal cancer trials -, SOUTH SAN FRANCISCO, Calif., ... company focused,on oncology, today provided an update of its picoplatin development ... prostate cancer (HRPC), and its oral formulation in solid,tumors. Presenting at ...
... Also This Month: Lessons Learned from the Avandia ... older,adults with diabetes live longer when they are ... December issue of Diabetes Care, which,publishes on November ... is an editorial by U.S. Food and Drug,Administration ...
Cached Medicine Technology:Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference 2Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference 3Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference 4Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference 5Treating Depression Prolongs Life for Older People with Diabetes 2
...
...
... The Premier Anterior Cervical Plate System ... screw translation along slots in the ... the distal end of the construct. ... has graft pre-compression features that enable ...
... for supportive stabilization of the anterior ... device utilizes bi-cortical fixation for stabilization. ... through dynamic screw holes and low ... interbody fusion. Anterior cervical corpectomy. Anterior ...
Medicine Products: