Navigation Links
Einstein scientist awarded $4 million to develop genetic strategy to combat tuberculosis
Date:10/4/2010

October 4, 2010 (BRONX, NY) William R. Jacobs, Jr., Ph.D., professor of microbiology & immunology and of genetics at Albert Einstein College of Medicine of Yeshiva University, who is also a Howard Hughes Medical Institute (HHMI) investigator, has been awarded a three-year, $4 million grant from the National Institutes of Health (NIH) to develop a novel genetic strategy for combating tuberculosis (TB). TB causes almost two million deaths each year, making it the world's most deadly bacterial infection.

In this ambitious project, Dr. Jacobs and colleagues will "knock out" every gene of Mycobacterium tuberculosis (MTB), the bacterium that causes TB. By knocking out or deleting a gene, researchers can determine the gene's function by observing how loss of that gene affects the organism. It is already known that certain MTB genes are crucial for the bacterium's survival helping it resist antibiotics, for example, and enabling it to ward off the immune system of the host.

The researchers will use a technique called specialized transduction (developed in the Jacobs lab) to generate approximately 4,500 specialized transducing phages. These phages will then be used to knock out every gene present in three different MTB strains, including the newly evolved extensively drug resistant (XDR-TB) strain.

Deletion libraries will be built in two different genetic backgrounds: H37Rv, the standard disease-causing laboratory strain; and mc26320, a nonpathogenic derivative of H37Rv. Since H37Rv is a pathogen, it must be studied under secure BSL3 laboratory conditions; by contrast, mc26320, an important strain used for vaccine studies, requires the less stringent BSL2 containment. The findings from this project will be made available to all qualified researchers worldwide via an NIH-designated depository and distribution center.

"TB strains that resist some, most or even all current chemotherapies are becoming increasingly common," said Dr. Jacobs. "We hope that our systematic evaluation of the entire TB genome will reveal genetic vulnerabilities that we can target with new and more effective treatments and vaccines."


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Einstein awarded NIH grant to study drug-resistant TB
2. NIH awards $10M to Einstein for diabetes research
3. NIH scientists describe how salmonella bacteria spread in humans
4. UNC scientists receive grant to develop nanotechnology for pancreatic cancer diagnosis and treatment
5. Unlocking the secret of beauty: Scientists discover the complexities of attractive female bodies
6. Symposium in Washington with world-leading scientists
7. Researcher seeks to create citizen scientists to help in response to environmental disasters
8. UC Davis scientists find link between arthritis pain reliever and cardiovascular events
9. Leading brain scientists meet in Milwaukee to examine how to uncover the brains secrets
10. NYU Langone scientists find key pathway implicated in progression of childhood cancer
11. Welsh scientists clone human virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Ill. (PRWEB) , ... October ... ... Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer ... healthcare professionals on guideline updates for the primary prevention of cardiovascular diseases ...
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... for healthcare compliance program management, will showcase a range of technology and learning ... Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 at ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017  PMD ... OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... strategic hub service that expedites and streamlines patient and ... Spiro PD 2.0, and wellness management services.  ... medical device used to measure lung function for a ...
Breaking Medicine Technology: