Navigation Links
Einstein scientist awarded $4 million to develop genetic strategy to combat tuberculosis

October 4, 2010 (BRONX, NY) William R. Jacobs, Jr., Ph.D., professor of microbiology & immunology and of genetics at Albert Einstein College of Medicine of Yeshiva University, who is also a Howard Hughes Medical Institute (HHMI) investigator, has been awarded a three-year, $4 million grant from the National Institutes of Health (NIH) to develop a novel genetic strategy for combating tuberculosis (TB). TB causes almost two million deaths each year, making it the world's most deadly bacterial infection.

In this ambitious project, Dr. Jacobs and colleagues will "knock out" every gene of Mycobacterium tuberculosis (MTB), the bacterium that causes TB. By knocking out or deleting a gene, researchers can determine the gene's function by observing how loss of that gene affects the organism. It is already known that certain MTB genes are crucial for the bacterium's survival helping it resist antibiotics, for example, and enabling it to ward off the immune system of the host.

The researchers will use a technique called specialized transduction (developed in the Jacobs lab) to generate approximately 4,500 specialized transducing phages. These phages will then be used to knock out every gene present in three different MTB strains, including the newly evolved extensively drug resistant (XDR-TB) strain.

Deletion libraries will be built in two different genetic backgrounds: H37Rv, the standard disease-causing laboratory strain; and mc26320, a nonpathogenic derivative of H37Rv. Since H37Rv is a pathogen, it must be studied under secure BSL3 laboratory conditions; by contrast, mc26320, an important strain used for vaccine studies, requires the less stringent BSL2 containment. The findings from this project will be made available to all qualified researchers worldwide via an NIH-designated depository and distribution center.

"TB strains that resist some, most or even all current chemotherapies are becoming increasingly common," said Dr. Jacobs. "We hope that our systematic evaluation of the entire TB genome will reveal genetic vulnerabilities that we can target with new and more effective treatments and vaccines."


Contact: Kim Newman
Albert Einstein College of Medicine

Related medicine news :

1. Einstein awarded NIH grant to study drug-resistant TB
2. NIH awards $10M to Einstein for diabetes research
3. NIH scientists describe how salmonella bacteria spread in humans
4. UNC scientists receive grant to develop nanotechnology for pancreatic cancer diagnosis and treatment
5. Unlocking the secret of beauty: Scientists discover the complexities of attractive female bodies
6. Symposium in Washington with world-leading scientists
7. Researcher seeks to create citizen scientists to help in response to environmental disasters
8. UC Davis scientists find link between arthritis pain reliever and cardiovascular events
9. Leading brain scientists meet in Milwaukee to examine how to uncover the brains secrets
10. NYU Langone scientists find key pathway implicated in progression of childhood cancer
11. Welsh scientists clone human virus
Post Your Comments:
(Date:11/27/2015)... PA (PRWEB) , ... November 27, 2015 , ... ... be a safe and convenient way to dispense prescription medications at home, so ... and effective way to monitor and dispense prescription medications. In doing so, it ...
(Date:11/27/2015)... ... ... ProSidebar: Fashion is a set of 30 kinetic edge graphics ... editors can easily add an informative sidebar to any FCPX production. Create lists, ... self-animating drop zones, lines, bars, and text with the ease of FCPX's drag and ...
(Date:11/27/2015)... ... ... A simply groundbreaking television series, "Voices in America", which is hosted by ... of issues that are presently affecting Americans. Dedicated to providing the world with a ... the subjects consumers focus on, one episode at a time. , In the ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and ... nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown commitment ... advance the healthcare industry as a whole through their advocacy and professional efforts. ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... located in central Michigan, have come together on Thanksgiving Day to share the ... available for viewing on the Serenity Point YouTube channel, patients displayed what they ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... november 2015 AAIPharma Services Corp./Cambridge ... investering aan van ten minste $15,8 miljoen ... het mondiale hoofdkantoor in Wilmington, ... in extra kantoorruimte en extra capaciteit voor ... behoeften van de farmaceutische en biotechnologische markten. ...
(Date:11/26/2015)... -- --> --> Juntendo ... optimal contrast weighting of MRI for patients with Multiple ... research agreement with SyntheticMR in order to use SyMRI in ... possible to generate multiple contrast images from a single scan ... thus making it possible to both fine tune images and ...
(Date:11/26/2015)... , Nov. 26, 2015 Research ... addition of the "2016 Future Horizons and ... (TDM) Market: Supplier Shares, Country Segment Forecasts, Competitive ... --> --> ... analysis of the Japanese therapeutic drug monitoring market, ...
Breaking Medicine Technology: