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Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
Date:3/6/2008

infected human cells and with reprogrammed nave CTLs into which the HIV-recognizing T-cell receptor genes had been inserted using the lentiviral delivery system. One week later, when the researchers looked for HIV-infected human cells in the animals, they found that the infected cells had virtually been eliminated.

Dr. Goldstein notes that this study was done using genes for just a single CTL T-cell receptor. To make this strategy even more effective, were now in the process of isolating a cocktail of CTL receptor genes that are specific for many different HIV peptidesan approach analogous to todays combination drug therapy for treating HIV infection, says Dr. Goldstein. Ultimately, wed like to remove CTLs from patients, convert them into potent HIV-specific CTLs by inserting a variety of HIV-specific CTL receptor genes, and then re-infuse these fresh, genetically reprogrammed CTLs back into patients. By reinforcing the immune system in this way, we hope to turn the tide of battle against HIV in favor of people infected with the virus.


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Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

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