Navigation Links
Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
Date:3/6/2008

, known as peptides, are displayed on the surface of the infected cellthe cells way of signaling the immune system that it is infected. Detecting virus-infected cells so they can then be eliminated is the job of CTLs and the protein molecules, known as T-cell receptors, that jut from their surface.

If a CTLs T-cell receptor has the right amino acid sequence, it will recognize the HIV peptide on the infected cell as foreign--prompting the CTL to multiply and attack the infected cell. But all too often, this battle between activated CTLs and HIV-infected cells ends badly. Why, then, are super CTLs of elite controllers so effective in killing HIV-infected cells"

The explanation, the Einstein researchers postulated, is that these CTLs express T-cell receptors that either have a knack for recognizing viral peptides that tend not to mutate, or they bind extremely tightly to HIV-infected cells, enabling the elite controllers to keep their HIV infections under control.

A CTLs T-cell receptor, which is as unique for each CTL as a persons fingerprint, consists of two chains, alpha and beta. To obtain the blueprint for making exceptionally potent HIV-specific T-cell receptors, the researchers isolated the genes that code for each of the two chains from the potent HIV-specific CTL. Then, as a way to efficiently insert both genes into nave CTLs (from people not infected with HIV), they developed an efficient delivery system in which the genes were combined and packaged inside a special type of virus, called a lentivirus. The lentiviruses then inserted these genes into the chromosomes of nave CTLs obtained from a nave donors blood and reprogrammed them into potent HIV-specific CTLs.

We demonstrated that these genetically reprogrammed CTLs have very strong activity in terms of killing HIV-infected cells in both test tubes and an animal model, says Dr. Goldstein. In some of the animal studies, for example, the researchers injected mice with both HIV-
'/>"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Einstein researchers discover gene mutations linked to longer lifespans
2. Einstein honors Dr. Stanley Nathenson with Marshall S. Horwitz Faculty Prize for Research Excellence
3. Johnson City Medical Center Begins Offering Einstein Bros. Menu Items at Second On Campus Location
4. Sens. Kerry, Boxer and Feinstein call on FDA to Establish Maximum Level for Lead in Lipstick
5. Testing delays cause severe AIDS complications, Einstein researchers find
6. Einstein scientists treat cancer as an infectious disease -- with promising results
7. Albert Einstein Healthcare Network Turns to InterviewDirect to Qualify Job Candidates
8. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
9. Researchers control growth rate of replacement blood vessels, tissues
10. New protein discovery helps researchers understand autoimmune diseases
11. UF researchers warn parents about dangers of childhood foot burns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... Triad Semiconductor, Inc. today announced that David ... former President of Linear Technology Corporation was appointed to ... technology and business expertise, and we are delighted that ... Hayden, Triad CEO and chairman. , Mr. Bell brings ... semiconductor experience to Triad's board. From 2008 to 2012, ...
(Date:9/16/2014)... The Fertility Centers of New England is ... The collaboration will give patients access to high-quality frozen ... the Fertility Centers of New England. , Fairfax Egg ... largest selection of frozen donor eggs. Access to frozen ... , The Donor is already screened and her ...
(Date:9/16/2014)... BamboofloorChina.com, a famous online supplier of bamboo products, has ... bamboo panels . The firm is now offering big ... high quality items. Please note that the big sale ... , According to the company’s chief executive officer, ... visit BamboofloorChina.com before September 28. BamboofloorChina.com is offering more ...
(Date:9/15/2014)... September 16, 2014 With the variety ... is difficult to know the details on each one. ... the potential substances falling into their teen’s hands. ... marijuana itself among high school students. With varied, misleading ... and elsewhere, it can be difficult for parents to ...
(Date:9/15/2014)... Hastings and Hastings, an experienced and established ... flat attorney fee for personal injury cases. The firm ... portion possible of their settlement or recovery as a ... personal property. In addition, Hastings and Hastings makes an ... that no fees are due unless a settlement or ...
Breaking Medicine News(10 mins):Health News:David Bell Joins Triad Semiconductor's Board of Directors 2Health News:FCNE Announces Partnership with Fairfax Egg Bank 2Health News:Cheap Bamboo Panels Unveiled By Famous Online Supplier BamboofloorChina.com 2Health News:Teen Rehab Center CEO Releases Top 4 Facts Parents Must Know About Synthetic Marijuana 2Health News:Teen Rehab Center CEO Releases Top 4 Facts Parents Must Know About Synthetic Marijuana 3Health News:Hastings And Hastings Announces One Flat Attorney Fee For Personal Injury Cases 2Health News:Hastings And Hastings Announces One Flat Attorney Fee For Personal Injury Cases 3
... is a potentially debilitating childhood disease. Early detection ... term joint damage and disability. Research has shown ... assessments in joint activity and sub-clinical disease, according ... Roentgen Ray Society,s annual meeting. The study, performed ...
... HealthDay Reporter , WEDNESDAY, May 4 (HealthDay News) -- ... prescribed inhaled steroids, British researchers found that the oral ... The oral medications, known as leukotriene-receptor antagonists, "have shown ... be considered for any patient, not as a last ...
... May 4 (HealthDay News) -- A gene essential to cardiac ... defects that cause a major proportion of childhood death from ... defects -- all malformations of the left ventricular outflow tract ... may play a role. "It is estimated that there ...
... LOUIS and DES MOINES, Iowa, May 4, 2011 The ... $4 million grant from the Howard G. Buffett Foundation to ... The grant will help fund the completion of the development ... Africans who depend upon sorghum as their staple diet. ...
... for cancer during childhood have an increased risk ... according to a new study in Gastroenterology ... Association (AGA) Institute. Compared with their siblings, cancer ... of the upper GI tract, lower GI tract ...
... 4 (HealthDay News) -- Vigorous exercise offers more of ... study finds. U.K. researchers compared 11 sedentary people ... assessed before, during, immediately following, and 20 minutes after ... more negative during and immediately after high-intensity exercise, compared ...
Cached Medicine News:Health News:Sonography complements physical exam in identifying juvenile inflammatory arthritis in children 2Health News:Asthma Pills Work as Well as Inhaled Steroids: Study 2Health News:Asthma Pills Work as Well as Inhaled Steroids: Study 3Health News:New Gene Linked to Congenital Heart Defects 2Health News:Grant funds next phase in bringing healthier sorghum closer to underserved communities 2Health News:Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications 2
(Date:9/15/2014)... 2014 /PRNewswire-iReach/ -- "Spain Aesthetic Lasers and Energy ... data on the Spain Aesthetic Lasers and Energy ... of US dollars, volume (in units) and average ... Body Contouring Devices (Laser-Assisted Liposuction (LAL) Devices (Nd:YAG ... Ultrasound-Assisted Liposuction (UAL) Devices and Power Assisted Liposuction ...
(Date:9/15/2014)... /PRNewswire-iReach/ -- On September 8, 2014, Dr. ... a Citizen Petition to Dr. Margaret Hamburg ... another Black Box Warning to Levaquin, Cipro, and ... a Black Box Warning for the following psychiatric ... or acts, loss of consciousness, delirium, depressed level ...
(Date:9/15/2014)... BRUSSELS , Sept. 15, 2014 ... Brussels:UCB) today announced results from several exploratory analyses of ... with low bone mineral density (BMD). Romosozumab is an ... inhibiting the protein sclerostin, thereby increasing bone formation and ... American Society for Bone and Mineral Research (ASBMR) 2014 ...
Breaking Medicine Technology:Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 2Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 3Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 4Spain Aesthetic Lasers and Energy Devices Market (LAL, RFAL, PAL, HIFU) Outlook to 2020 5Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 2Quinolone Vigilance Foundation Supports Citizen Petition Requesting Another Black Box Warning for Levaquin, Cipro, Avelox 3New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 2New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 3New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 4New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 5New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 6New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 7New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 8New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 9New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 10New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 11New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 12New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 13New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 14New Analyses Of Phase 2 Study Presented At ASBMR Show Romosozumab Treatment Resulted In Continued Increases In Bone Mineral Density 15
... Laboratories Platelia Aspergillus EIA is a one-stage ... monoclonal antibody EBA-2 to detect circulating galactomannan ... 3 hours. , ,When used in conjunction ... is an aid in the diagnosis of ...
... The GreenLight PV Laser System ... the Prostate) Procedure for the ... (BPH) allows the urologist to ... a TURP with the safety ...
... diagnosis is generally confirmed by a positive heterophil ... however, is not indicated by the heterophil antibody ... - 20 percent of children. Detection and ... fully ascertain the stage of EBV infection. ...
... Bard® Biopsy Instrument and Needle is specially ... goal: a large quality, reliable core sample. ... featuring ultra-sharp tips and polished surfaces for ... of biopsy systems and needle sizes assures ...
Medicine Products: