Navigation Links
Einstein researchers discover protein that contributes to cancer spread
Date:12/8/2008

December 8, 2008 BRONX, NY - In an important finding published online in Developmental Cell, researchers at Albert Einstein College of Medicine of Yeshiva University, along with collaborators at Massachusetts Institute of Technology, have identified a protein likely responsible for causing breast cancer to spread.

Metastatic cancer occurs when cancer cells from the original tumor travel to distant sites via the blood system. Most cancer deaths are due to cancer that has spread to other organs. Trying to stop cancer before it metastasizes is the main goal of cancer treatments. Upon diagnosis, 6 out of 10 breast cancer patients have cancer that is still in its primary location making the potential discovery of a marker for invasive cancer of tremendous value that could better inform treatment options.

Until now, early markers of metastatic breast cancer have been hard to find. However, in the Einstein-led study, researchers have identified a protein that is a promising candidate for a metastatic breast cancer marker.

The protein, called Menainv is present in invasive cells within a breast tumor. These cells move into surrounding tissue and eventually to blood vessels. Menainv is not on breast tumor cells that stay put (resident cells). This is the first time that a protein has been shown to contribute to the invasive and metastatic ability of tumor cells, rather than just being an 'innocent bystander' that shows up when cells are invading, strengthening the potential use of this protein as a marker.

The research was conducted under the direction of and in the laboratories of John S. Condeelis, Ph.D., Einstein professor and co-chair of anatomy and structural biology and co-director of Gruss Lipper Biophotonics Center and Frank B. Gertler, Ph.D., Ross Scholar Professor of Biology at MIT.

The latest research was aided considerably by the work of Jeffrey B. Wyckoff, principal associate, department of anatomy and structural biology at Einstein who, with Dr. Condeelis, developed the in vivo invasion assay used to isolate metastatic tumor cells from breast tumors thereby implicating Mena as an important gene for metastasis.

Evanthia T. Roussos, an M.D.-Ph.D. student in Dr. Condeelis' lab and primary co-author of the study, explains, "We have micro-needles filled with growth factors and tissue that we insert into a tumor on an anesthetized mouse. If a cell is invasive, within four hours, it will crawl into the needles. We found that mouse breast tumor cells that we engineered to contain Menainv were invasive whereas cells that did not have Menainv were not."

Another finding from the study that has important implications for patient treatment is that tumor cells harboring Menainv are less likely to be responsive to newer breast cancer treatments that inhibit epidermal growth factor receptors (EGFR). Epidermal growth factor (EGF) has been shown to increase a breast cancer cell's invasive potential. The study investigators propose that drugs which inhibit EGF may lack effectiveness on tumor cells that express Menainv. That's because Menainvcells are so sensitive to EGF that even the small amount of EGF signal that the drugs fail to block may be enough to stimulate EGF receptor and promote tumor cell migration and metastasis.

If Menainv behaves similarly in humans as it does in mice, it would be an especially attractive marker for metastatic breast cancer because the structure of Menainv would enable an antibody or a PCR assay to be developed to identify it. Such an antibody or PCR assay could be used to diagnose the presence of Menainv in biopsies and blood samples allowing doctors to identify breast cancer patients who are more likely to have progressive disease and recommend the appropriate treatment.

The current study builds on previous research by Dr. Condeelis' group which identified Menainv as the isoform of Mena that is over expressed in the invasive and metastatic subpopulation of tumor cells in breast tumors. The current study shows that Menainv forces tumor cells in mammary tumors of mice to become invasive and eventually metastasize to the lung.


'/>"/>

Contact: Michael Heller
mheller@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
2. Albert Einstein Healthcare Network Turns to InterviewDirect to Qualify Job Candidates
3. Einstein scientists treat cancer as an infectious disease -- with promising results
4. Testing delays cause severe AIDS complications, Einstein researchers find
5. Sens. Kerry, Boxer and Feinstein call on FDA to Establish Maximum Level for Lead in Lipstick
6. Johnson City Medical Center Begins Offering Einstein Bros. Menu Items at Second On Campus Location
7. Einstein honors Dr. Stanley Nathenson with Marshall S. Horwitz Faculty Prize for Research Excellence
8. Einstein researchers discover gene mutations linked to longer lifespans
9. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
10. Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment
11. Pioneering Heart Surgeon, Robert E. Michler, M.D., Appointed Chair of Surgery and Surgeon-in-Chief at Einstein and at Montefiore Medical Center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... article about foods choices that promote eye health. These articles generally list between ... Water and health advocate Sharon Kleyne endorses every one of these lists and ...
(Date:2/12/2016)... Highlands Ranch, Colo. (PRWEB) , ... February 12, 2016 , ... ... particularly over the past 35 years. A president has access to health and wellness ... leader of the free world, no single individual has a schedule as frenetic as ...
(Date:2/12/2016)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in ... are the real facts surrounding all those Bible stories. For generations families have gathered ... and Yisrayl says there is more to these than just mere “stories”. , ...
(Date:2/12/2016)... Phoenix, AZ (PRWEB) , ... February 12, 2016 , ... ... Health Arizona General Hospital Emergency Room –Mesa. The new facility is licensed under ... Valley. , “Dr. Bingham is an excellent leader and will ensure our new ...
(Date:2/11/2016)... ... 11, 2016 , ... SPH Analytics announced today that ... health solutions, MDinsight® and IndiGO®, for its primary care clinicians. The 3-year partnership ... the contract were not disclosed. , As the healthcare market moves towards quality-based ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016 AAIPharma Services Corp./Cambridge Major Laboratories, ... and development services for the pharmaceutical and biotechnology ... capacity in its Charleston, SC ... several recent investments. Charleston ... line with small-scale lyophilization. The site has invested ...
(Date:2/11/2016)... ANKENY, Iowa , 11 de fevereiro de ... a inauguração de sua fábrica de soroalbumina bovina ... Nova Zelândia. A fábrica fica na Ilha Norte ... Loop "), desenvolvido e estabelecido na fábrica da ... Iowa . O projeto e instalação dos ...
(Date:2/11/2016)... Breast Cancer Therapeutics in Asia-Pacific Markets ... (APAC) breast cancer market will experience considerable expansion ... at a Compound Annual Growth Rate (CAGR) of 8.5%. ... - states that the Asia-Pacific ... billion in 2014 to $3.4 billion by 2021, at a ...
Breaking Medicine Technology: