Navigation Links
Einstein researchers discover gene mutations linked to longer lifespans
Date:3/4/2008

March 4, 2008 (Bronx, NY) Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found. Their research is described in the March 4 issue of the Proceedings of the National Academy of Sciences.

The report is the latest finding in the Einstein researchers ongoing search for genetic clues to longevity through their study that by now has recruited more than 450 Ashkenazi (Eastern European) Jews between the ages of 95 and 110. Descended from a small founder group, Ashkenazi Jews are more genetically uniform than other groups, making it easier to spot gene differences that are present. In 2003, this study resulted in the first two longevity genes ever identifiedfindings that have since been validated by other research.

The present study focused on genes involved in the action of insulin-like growth factor (IGF-I), a hormone that in humans is regulated by human growth hormone. Affecting virtually every cell type in the body, IGF-I is crucially important for childrens growth and continues contributing to tissue synthesis into adulthood. The IGF-I cell-signaling pathway is triggered when IGF-I molecules circulating in blood plasma latch onto receptors on the surface of cells, causing a signal to be sent to the cells nucleus that may, for example, tell that cell to divide.

Animal research had shown that mutations to genes involved in the IGF-I signaling pathway cause two effects: Affected animals have impaired growth but also longer life spans. So the Einstein scientists reasoned that altered signaling in this pathway might also influence human longevity. To find out, they analyzed IGF-I-related genetic variations in 384 Ashkenazi Jewish centenarians. And since plasma levels of IGF-I do not reflect their levels at a younger age, the researchers also looked at two other groups: the children of these centenarians, and a control gr
'/>"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
2. Albert Einstein Healthcare Network Turns to InterviewDirect to Qualify Job Candidates
3. Einstein scientists treat cancer as an infectious disease -- with promising results
4. Testing delays cause severe AIDS complications, Einstein researchers find
5. Sens. Kerry, Boxer and Feinstein call on FDA to Establish Maximum Level for Lead in Lipstick
6. Johnson City Medical Center Begins Offering Einstein Bros. Menu Items at Second On Campus Location
7. Einstein honors Dr. Stanley Nathenson with Marshall S. Horwitz Faculty Prize for Research Excellence
8. Stanford researchers find culprit in aging muscles that heal poorly
9. UCLA researchers identify markers that may predict diabetes in still-healthy people
10. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
11. Bipolar disorder relapses halved by Melbourne researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2015)... 2015 Over 50 million women across ... undiagnosed autoimmune, thyroid, or hormone disorders. , Dr. Joni ... treated hundreds of patients dealing with these conditions, but ... treatment options for their ailments. Her new book, “Why ... living with fatigue, brain fog, and sleepless nights. , ...
(Date:3/29/2015)... Metamora, MI. (PRWEB) March 29, 2015 ... offers comprehensive menopause treatment. Secondary to their location ... a closer hospital option. They continue to be ... Oakland. , Menopause is a normal condition ... "menopause" can describe any of the changes a woman ...
(Date:3/29/2015)... (PRWEB) March 29, 2015 Adults who ... agencies promote nationally on the web can now use ... life insurance quotes can now be explored while researching ... . , Learning the differences between what a term ... be a challenge for some men and women. Insurers ...
(Date:3/29/2015)... IN (PRWEB) March 29, 2015 The culmination ... world is coming when the Final Four invades ... basketball tournament has been one filled with excitement, buzzer-beaters, and ... have been busted, superstars have been made, and future professional ... just be down to the four teams that advanced through ...
(Date:3/29/2015)... The Contract Research Organizations industry ... manage data results and help develop and formulate ... standards. Contract research organizations (CROs) mainly serve clients ... Industry operators provide clients with a full range ... for Food and Drug Administration (FDA) approval. CROs ...
Breaking Medicine News(10 mins):Health News:How to Turn Mid-life into the Good Life 2Health News:Women's Excellence Affiliates with Beaumont Hospital, Treats Menopause 2Health News:Permanent Life Insurance Quotes Now Offered Through Web Search System at Insurer Website Online 2Health News:Cheap 2015 Final Four Tickets: Ticket Down Slashes Kentucky Wildcats and Wisconsin Badgers Final Four Tickets at Lucas Oil Stadium and Issues Valuable Promo Code 2Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 4
... for the disease, researchers say, , , WEDNESDAY, March 18 (HealthDay ... hepatitis C virus (HCV) in the human body have been ... found that blocking several of the genes suppressed replication of ... from developing therapies based on these findings, but this study ...
... and eyelid surgery were ranked the top 3 cosmetic surgery procedures in ... Aesthetic Plastic Surgery. The clinical results of New Jersey plastic surgeon ... , ... Paramus, NJ (Vocus) March 19, 2009 -- Dr. Paul Parker, ...
... The University of Pittsburgh School of Medicine has received ... of Health to find new ways to stop deadly ... grant, funded by Pennsylvania,s share of the national 2008-2009 ... A. baumannii and the drug-resistant bacteria known ...
... having many close friends contributes to poorer health for ... even greater health risks, research at the University of ... to being alone don,t have the same health problems. ... the relationships between health and two different types of ...
... Fulfilling President Obama,s pledge to "stand with our veterans ... Eric K. Shinseki announced today that the Department of ... for its existing facility in Denver. The new ... Army,s former Fitzsimons hospital in Aurora.The new medical center ...
... is Autism Awareness Month and to celebrate, renowned osteopathic ... of Kids, Brain Trust, a nonprofit clinic that aims ... validated specialty. KBT will provide one year of free ... is anticipated to begin in Spring 2009 for pediatric ...
Cached Medicine News:Health News:Progress Reported Against Gene Involved in Hepatitis C 2Health News:New Jersey Plastic Surgeon Helps Determine Top Cosmetic Surgery Procedures of 2008 2Health News:New Jersey Plastic Surgeon Helps Determine Top Cosmetic Surgery Procedures of 2008 3Health News:Pitt receives $4.7 million award to reduce hospital-acquired infections 2Health News:Few friends combined with loneliness linked to poor mental and physical health for elderly 2Health News:Few friends combined with loneliness linked to poor mental and physical health for elderly 3Health News:VA to Build Stand-Alone Replacement Hospital in Denver 2Health News:Kids' Brain Trust: A New Nonprofit Gives Parents Hope of Defeating Autism 2
(Date:3/27/2015)... The Temple Health & Bioscience District (THBD) today ... at 1802 South First St. in the Temple Medical and ... City of Temple to receive funding for ... Texas Veterans Health Care System, the new facility will enable ... biotechnology and life science companies. ...
(Date:3/27/2015)... , March 27, 2015 A new report from ... America – Chile , ... are top targets for IVD firms.  The healthcare research firm ... into IVD strategies for the Latin American continent with a ... globally distributed supply operations. However, the country,s regional economic clout ...
(Date:3/27/2015)... Zimmer Holdings, Inc. (NYSE and SIX: ZMH) is ... patients. Available in both small (6mm) and ... Fixation System from Zimmer is a modular system that offers ... XtraFix System allows surgeons to eliminate steps, as ... resulting in saved time, costs and overall team effort. ...
Breaking Medicine Technology:Temple Health & Bioscience District Relocates, Offers Office And Lab Space To Biotech Companies 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 2Kalorama: Beyond Brazil, Latin American IVD Market Grows 3Kalorama: Beyond Brazil, Latin American IVD Market Grows 4Zimmer Debuts New Modular External Fixation System 2Zimmer Debuts New Modular External Fixation System 3
... , NEW YORK, ... research report is available in its catalogue: , ... , http://www.reportlinker.com/p0164335/Cardiac-Pacemakers---A-World-Market-Analysis.html , Pacemaker devices constitute ... market. The worldwide cardiac pacemakers market is characterized by ...
... ... a new market research report is available in its ... Global Market Perspective , http://www.reportlinker.com/p0164320/Electrodes-for-Medical-Devices---A-Global-Market-Perspective.html , ... muscle and nerve cells that are created by chemical ...
Cached Medicine Technology:Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 2Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 3Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 4Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 5Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 6Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 7Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 8Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 9Reportlinker Adds Cardiac Pacemakers - A World Market Analysis 10Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 2Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 3Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 4Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 5Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 6Reportlinker Adds Electrodes for Medical Devices - A Global Market Perspective 7
Anesthetists Precordial Kit incudes one set of 4 chromed plated chest pieces, a reusable monoscope of your choice, and 20 precordial adhesive discs....
For accurately monitoring heart and breath sounds....
For accurately monitoring core temperature and heart and breath sounds....
... Level 1 enables hospitals ... patient monitors to a ... Our temperature monitoring disposale ... are superior in their ...
Medicine Products: