Navigation Links
Einstein researchers discover gene mutations linked to longer lifespans
Date:3/4/2008

March 4, 2008 (Bronx, NY) Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found. Their research is described in the March 4 issue of the Proceedings of the National Academy of Sciences.

The report is the latest finding in the Einstein researchers ongoing search for genetic clues to longevity through their study that by now has recruited more than 450 Ashkenazi (Eastern European) Jews between the ages of 95 and 110. Descended from a small founder group, Ashkenazi Jews are more genetically uniform than other groups, making it easier to spot gene differences that are present. In 2003, this study resulted in the first two longevity genes ever identifiedfindings that have since been validated by other research.

The present study focused on genes involved in the action of insulin-like growth factor (IGF-I), a hormone that in humans is regulated by human growth hormone. Affecting virtually every cell type in the body, IGF-I is crucially important for childrens growth and continues contributing to tissue synthesis into adulthood. The IGF-I cell-signaling pathway is triggered when IGF-I molecules circulating in blood plasma latch onto receptors on the surface of cells, causing a signal to be sent to the cells nucleus that may, for example, tell that cell to divide.

Animal research had shown that mutations to genes involved in the IGF-I signaling pathway cause two effects: Affected animals have impaired growth but also longer life spans. So the Einstein scientists reasoned that altered signaling in this pathway might also influence human longevity. To find out, they analyzed IGF-I-related genetic variations in 384 Ashkenazi Jewish centenarians. And since plasma levels of IGF-I do not reflect their levels at a younger age, the researchers also looked at two other groups: the children of these centenarians, and a control gr
'/>"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
2. Albert Einstein Healthcare Network Turns to InterviewDirect to Qualify Job Candidates
3. Einstein scientists treat cancer as an infectious disease -- with promising results
4. Testing delays cause severe AIDS complications, Einstein researchers find
5. Sens. Kerry, Boxer and Feinstein call on FDA to Establish Maximum Level for Lead in Lipstick
6. Johnson City Medical Center Begins Offering Einstein Bros. Menu Items at Second On Campus Location
7. Einstein honors Dr. Stanley Nathenson with Marshall S. Horwitz Faculty Prize for Research Excellence
8. Stanford researchers find culprit in aging muscles that heal poorly
9. UCLA researchers identify markers that may predict diabetes in still-healthy people
10. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
11. Bipolar disorder relapses halved by Melbourne researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Dennis Thompson HealthDay Reporter ... Coupled with worldwide marches demanding action on climate change, ... weather patterns in the United States may soon exacerbate ... and other heat-related illnesses are expected to increase as ... author Dr. Jonathan Patz, director of the Global Health ...
(Date:9/23/2014)... at Cincinnati Children,s Hospital Medical Center have published ... (EG). The study, published in The Journal ... EG is a systemic disorder that has high ... tract, involves a series of allergy-associated-immune mechanisms and ... distinct from that of a related disorder, eosinophilic ...
(Date:9/23/2014)... a potential source of student diversity for medical ... however, there are significant challenges to enhancing the ... medical schools. The authors recommend that medical school ... be more inclusive of community college students. , ... Francisco and San Jose City College found that, ...
(Date:9/23/2014)... shows that adolescents who suffer from sleep disturbance or ... academically compared to those who enjoy a good night,s ... journal Sleep Medicine . , In a new ... and 19 from Uppsala County, researchers from Uppsala University ... sleep duration (less than 7 hours per day) increased ...
(Date:9/23/2014)... PA (PRWEB) September 23, 2014 If ... ongoing dialysis, dressing for the treatment may be a ... a type of garment that is designed to improve ... patients to receive dialysis without having to remove, tear ... while insuring privacy and preserving their dignity. At the ...
Breaking Medicine News(10 mins):Health News:Health Woes to Worsen Due to Climate Change, Study Warns 2Health News:Health Woes to Worsen Due to Climate Change, Study Warns 3Health News:Advancing the understanding of an understudied food allergy disorder 2Health News:Advancing the understanding of an understudied food allergy disorder 3Health News:Medical students who attended community college likelier to serve poor communities 2Health News:Apparel for Dialysis Patients Invented by InventHelp Client (CBA-2492) 2
... a quarter million deaths in the United States annually, ... as prescribed . A Mayo Clinic research team has ... medications. The tool is clearly effective and preferred by ... in the May 28 issue of the Archives of ...
... increase levels of high-density lipoprotein, or 'good,' ... issue of Archives of Internal Medicine. ... is an independent risk factor for cardiovascular disease, ... background information in the article. There is strong ...
... better predict the likelihood of full or partial recovery ... according to a study published in the June issue ... that the possibility and extent of neurological recovery after ... by rigorous assessment of MR images," said co-author Michael ...
... Asia - including India's - met European Union members in ... crises. ,The two-day Asia-Europe Meeting (ASEM) of 43 ... seeking deep cuts in world carbon-dioxide emissions and Asian governments ... held every two years. India, Pakistan and Mongolia are attending ...
... multidetector computed tomography (MDCT) can aid forensics teams in ... study published in the June issue of Radiology . ... demonstrating airway froth and sediment that are indicative of ... be used either to facilitate or reduce the need ...
... genes may actually contribute to learning the supposed "tonal languages", ... of Edinburgh University, UK, have exposed the first obvious connection ... in tonal languages can fundamentally alter the meaning of words, ... are so tough to learn for speakers of non-tonal languages ...
Cached Medicine News:Health News:Simple Tool Developed for Diabetics to Improve Compliance With Medications 2Health News:Simple Tool Developed for Diabetics to Improve Compliance With Medications 3Health News:Regular Exercise may Slightly Increase HDL Levels 2Health News:Recovery from Spinal Cord Injury can Be Predicted Using MRI 2Health News:EU Pushes Asian Nations on Climate Change Goals 2Health News:Death Due to Drowning can Be Identified With the Aid of 'Virtual Autopsy' 2Health News:Genes may Have a Role in Learning "tonal Languages" 2
(Date:9/23/2014)... , Sept. 23, 2014 Cerevast Therapeutics ... today the outcome of the first interim analysis ... the Company,s proprietary Clotbust ER TM ... ischemic stroke. The independent Data Safety Monitoring Board ... planned. "Clearing the pre-specified futility threshold ...
(Date:9/23/2014)... therapy recently began in the Czech Republic for ... the United States draws to a close today ... days to live now looks forward to his first day of kindergarten. ... complained of a headache in June, it was the first ... 23, when he completes proton radiation therapy for a brain ...
(Date:9/23/2014)... Sept. 23, 2014 CASI Pharmaceuticals, Inc. (Nasdaq: ... the acquisition, development and commercialization of innovative therapeutics addressing ... market with a primary focus on China ... Shrotriya , MD, Chairman and Chief Executive Officer of ... appointment was made in connection with the recently announced ...
Breaking Medicine Technology:Cerevast Therapeutics Announces Outcome of First Interim Analysis of Phase 3 CLOTBUSTER Trial for the Treatment of Acute Ischemic Stroke 2Cerevast Therapeutics Announces Outcome of First Interim Analysis of Phase 3 CLOTBUSTER Trial for the Treatment of Acute Ischemic Stroke 35-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 25-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 35-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 4CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 2CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 3CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 4
... , WASHINGTON, Jan. 11 ... Baseball star Aaron Boone is featured in January on , Sharing ... that tells the compelling and inspirational stories of real patients. , Sharing ... is sponsored by the Pharmaceutical Research and Manufacturers of America ...
... , , SAN JOSE, Calif., Jan. ... and control solutions for life sciences process applications, announced ... TruFluor sensors for dissolved oxygen or pH and process ... family is optimized for accuracy, lifetime, and ease of ...
Cached Medicine Technology:Major League Baseball Star Aaron Boone on 'Sharing Miracles' 2Major League Baseball Star Aaron Boone on 'Sharing Miracles' 3Single-Use Sensor Product Family Enters High Volume Production 2
... manufactures slides that are compatible with multichannel ... the number of pipetting steps required to ... on the slides. Ask Immuno Concepts for ... slides. These slide formats are noted with ...
... ANA uses a patented HEp-2 cell line ... the sensitivity to SS-A/Ro autoantibodies, without affecting ... studies have been published worldwide on the ... to SS-A/Ro autoantibodies when used in place ...
... and ENA assays can be used ... antinuclear antibodies, which are associated with ... Systemic lupus erythematosus (Lupus), Sjgren's syndrome, ... sclerosis, scleroderma, polymyositis, dermatomyositis, and Raynaud's ...
... assays can be used to screen ... which are associated with various systemic ... erythematosus (Lupus), Sjgren's syndrome, mixed connective ... polymyositis, dermatomyositis, and Raynaud's phenomenon. They ...
Medicine Products: