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Einstein helps establish $28 million consortium to find ebola treatment
Date:3/20/2014

ew antiviral antibodies and to assess their effectiveness.

"Our consortium represents an unprecedented soup-to-nuts effort to develop antibody therapeutics against hemorrhagic fever viruses," said Dr. Chandran, associate professor of microbiology & immunology and the Harold and Muriel Block Faculty Scholar in Virology at Einstein. "These products, when translated into clinical practice, will provide a much needed pre- or post-exposure therapy against some of the world's most lethal viruses."

Dr. Chandran will receive $2 million of the total grant and serve as co-director of the mechanistic virology core for this project, along with Yoshihiro Kawaoka, Ph.D., D.V.M., at the University of WisconsinMadison. "Our core will support all individual research projects within the consortium by assessing how well each antibody works and the mechanism by which it blocks infection. This will help us design antibody cocktails with the best chance of working in animals," said Dr. Chandran. His lab at Einstein carries out both basic and translational research on Ebola virus and identified an essential receptor that Ebola uses to enter cells and cause infection.

Developing Antibodies

Dr. Lai, an expert in antibody technologies at Einstein, will focus on discovering new immunotherapeutic candidates against the Sudan Ebola virus and Marburg virus. "We aim to fill critical gaps in the antibody pipeline against these specific filoviruses," said Dr. Lai, associate professor of

Contact: Deirdre Branley
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

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