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Efficient analysis of small quantity of cells improves chances to understand disease
Date:4/14/2014

precipitation (ChIP) to examine the protein binding to DNA sites. The unique aspect of Lu's procedure is it produces reliable results based on as few as 10 to 100 cells as opposed to the previous standard that required as many as millions of cells, giving researchers a much more manageable process to use. The early versions of the work on this procedure were described in the journal, Lab on a Chip.

Lu's group will then monitor the same live mouse over the course of the disease development.

"We believe that the single live animal data will grant unique insights into the molecular events involved in these biological processes and provide an important basis for diagnosis, prognosis, drug design and discovery, and treatment strategy. Such data also most closely mimic what occurs in human patients during disease development and treatment, thus offering direct clinical relevance," Lu explained.

Lu's specific technique (dubbed as microfluidic chromatin immunoprecipitation) is the subject of a patent filed by Virginia Tech Intellectual Properties (VTIP) on his behalf, and the group's research appears in premier microfluidics and biomedical technology journals.

Lu earned his bachelor's degree in chemistry at Peking University in 1998, followed by a master's and a doctoral degree in chemical engineering in 2001 and in 2002, respectively, from the University of Illinois at Urbana-Champaign. He was a post-doctoral research fellow in applied physics at Cornell University from 2002 until 2004.


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Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

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