Navigation Links
Efficient analysis of small quantity of cells improves chances to understand disease
Date:4/14/2014

For more than a decade Chang Lu, associate professor of chemical engineering at Virginia Tech, has worked on the development of tools to efficiently analyze living cells. The long-term goal is to gain a better understanding of a range of diseases.

In his lab, Lu and his students develop small devices with micrometer features for examining molecular events inside cells. These devices promote high sensitivity and are particularly suited for studying a low number of cells.

Based on their record of achievements, the National Institutes of Health (NIH) has awarded Lu a new $1.3 million, four-year research project, commonly referred to as an RO1 grant, to continue his work in probing dynamics in protein-DNA interactions during disease development. His collaborators are Liwu Li, professor of biological sciences at Virginia Tech, and Kai Tan, associate professor of internal medicine of the University of Iowa Carver College of Medicine.

Lu's earlier awards include a prestigious National Science Foundation CAREER Award and a Walter H. Coulter Early Career Award in Biomedical Engineering. He is also a core member of the School of Biomedical Engineering and Sciences, part of the Institute for Critical Technology and Applied Science at Virginia Tech.

Under the support of the new R01 grant, they will use live animal experiments with laboratory mice to understand the changes in the protein-DNA interaction as a disease develops, using tiny amounts of blood samples.

These blood samples are processed through Lu's investigative procedure called chromatin immunoprecipitation (ChIP) to examine the protein binding to DNA sites. The unique aspect of Lu's procedure is it produces reliable results based on as few as 10 to 100 cells as opposed to the previous standard that required as many as millions of cells, giving researchers a much more manageable process to use. The early versions of the work on this procedure were described in the journal, Lab on a Chip.

Lu's group will then monitor the same live mouse over the course of the disease development.

"We believe that the single live animal data will grant unique insights into the molecular events involved in these biological processes and provide an important basis for diagnosis, prognosis, drug design and discovery, and treatment strategy. Such data also most closely mimic what occurs in human patients during disease development and treatment, thus offering direct clinical relevance," Lu explained.

Lu's specific technique (dubbed as microfluidic chromatin immunoprecipitation) is the subject of a patent filed by Virginia Tech Intellectual Properties (VTIP) on his behalf, and the group's research appears in premier microfluidics and biomedical technology journals.

Lu earned his bachelor's degree in chemistry at Peking University in 1998, followed by a master's and a doctoral degree in chemical engineering in 2001 and in 2002, respectively, from the University of Illinois at Urbana-Champaign. He was a post-doctoral research fellow in applied physics at Cornell University from 2002 until 2004.


'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

Related medicine news :

1. Stand-alone facility for organ retrieval is more efficient, less costly than hospital
2. Neuropsychological assessment more efficient than MRI for tracking disease progression
3. Sensor system improves air quality while making building ventilation more energy efficient
4. Automated system could efficiently identify high-risk osteoporosis patients
5. Successful and Busy Veterinary Clinics: Become More Efficient with Updated and Advanced Time Clock Software
6. How to Make 2014 the Year Your Agency Becomes More Efficient, Improves Communication and Goes Mobile with Online Services from Aladtec
7. National Energy Technologies Announces the Addition of a Revolutionary New Efficient Motor
8. Los Angeles Hair Transplant Surgeon Doubles the Number of Grafts in FUE Hair Restorations Producing More Efficient FUE Hair Transplantation
9. More Efficient Way to Grow Heart Muscle from Stem Cells Could Yield New Regenerative Therapies
10. H7N9 influenza virus not adapted to efficient human-to-human transmission
11. Couple Chooses Endless Pool for Their Energy Efficient Home
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Efficient analysis of small quantity of cells improves chances to understand disease
(Date:7/25/2017)... OK (PRWEB) , ... July 25, 2017 , ... ... proud to announce the launch of their partnership to provide the Pharmacist ... the first pharmacy-focused platform in the country with the ability to develop the ...
(Date:7/25/2017)... ... July 25, 2017 , ... Therachat ... will be exhibiting and providing demos of its smart journaling platform at the ... Center in Washington D.C. from August 3-6, 2017. , The APA Annual Convention ...
(Date:7/25/2017)... , ... July 25, 2017 , ... ... ATM provider in the United States, today announced its partnership with financial technology ... , The foundation of the solution lies within Hyosung’s superior ATMs, assisted ...
(Date:7/25/2017)... Jacksonville, Fla. (PRWEB) , ... July 25, 2017 , ... ... employee and father Ezra Clark is taking advantage of a new benefit for employees ... “It really means a lot that the company supports me and other employees as ...
(Date:7/25/2017)... TX (PRWEB) , ... July 25, 2017 , ... SignatureCare ... emergencies in the Austin, TX area 24 Hours a day. , The ... Austin, TX. , “We’ve been open four months now and things are running ...
Breaking Medicine News(10 mins):
(Date:7/25/2017)... and CAMBRIDGE, Massachusetts , July 25, 2017 ... repurposing drugs to treat rare nervous system diseases, has concluded ... develop and market the drug SOM0226 against transthyretin amyloidosis (ATTR). ... very promising results in a Phase 2 study conducted in ... office in the United States ...
(Date:7/24/2017)... July 24, 2017 IBM (NYSE: IBM ) ... Quadrant for Solid-State Arrays (SSA) for the fourth year in ... According to Gartner, "Vendors in the Leaders quadrant have the ... Vision. A vendor in the Leaders quadrant has the market ... the acceptance of new technologies. These vendors demonstrate a clear ...
(Date:7/21/2017)... EDMONTON, Alberta , July 21, 2017 /PRNewswire/ ... University of Alberta in Edmonton, Canada ... partner journal, Schizophrenia 1 , demonstrating that AI ... schizophrenia with 74% accuracy. This retrospective analysis also ... symptoms in schizophrenia patients with significant correlation, based ...
Breaking Medicine Technology: