Navigation Links
Efficient analysis of small quantity of cells improves chances to understand disease
Date:4/14/2014

For more than a decade Chang Lu, associate professor of chemical engineering at Virginia Tech, has worked on the development of tools to efficiently analyze living cells. The long-term goal is to gain a better understanding of a range of diseases.

In his lab, Lu and his students develop small devices with micrometer features for examining molecular events inside cells. These devices promote high sensitivity and are particularly suited for studying a low number of cells.

Based on their record of achievements, the National Institutes of Health (NIH) has awarded Lu a new $1.3 million, four-year research project, commonly referred to as an RO1 grant, to continue his work in probing dynamics in protein-DNA interactions during disease development. His collaborators are Liwu Li, professor of biological sciences at Virginia Tech, and Kai Tan, associate professor of internal medicine of the University of Iowa Carver College of Medicine.

Lu's earlier awards include a prestigious National Science Foundation CAREER Award and a Walter H. Coulter Early Career Award in Biomedical Engineering. He is also a core member of the School of Biomedical Engineering and Sciences, part of the Institute for Critical Technology and Applied Science at Virginia Tech.

Under the support of the new R01 grant, they will use live animal experiments with laboratory mice to understand the changes in the protein-DNA interaction as a disease develops, using tiny amounts of blood samples.

These blood samples are processed through Lu's investigative procedure called chromatin immunoprecipitation (ChIP) to examine the protein binding to DNA sites. The unique aspect of Lu's procedure is it produces reliable results based on as few as 10 to 100 cells as opposed to the previous standard that required as many as millions of cells, giving researchers a much more manageable process to use. The early versions of the work on this procedure were described in the journal, Lab on a Chip.

Lu's group will then monitor the same live mouse over the course of the disease development.

"We believe that the single live animal data will grant unique insights into the molecular events involved in these biological processes and provide an important basis for diagnosis, prognosis, drug design and discovery, and treatment strategy. Such data also most closely mimic what occurs in human patients during disease development and treatment, thus offering direct clinical relevance," Lu explained.

Lu's specific technique (dubbed as microfluidic chromatin immunoprecipitation) is the subject of a patent filed by Virginia Tech Intellectual Properties (VTIP) on his behalf, and the group's research appears in premier microfluidics and biomedical technology journals.

Lu earned his bachelor's degree in chemistry at Peking University in 1998, followed by a master's and a doctoral degree in chemical engineering in 2001 and in 2002, respectively, from the University of Illinois at Urbana-Champaign. He was a post-doctoral research fellow in applied physics at Cornell University from 2002 until 2004.


'/>"/>

Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

Related medicine news :

1. Stand-alone facility for organ retrieval is more efficient, less costly than hospital
2. Neuropsychological assessment more efficient than MRI for tracking disease progression
3. Sensor system improves air quality while making building ventilation more energy efficient
4. Automated system could efficiently identify high-risk osteoporosis patients
5. Successful and Busy Veterinary Clinics: Become More Efficient with Updated and Advanced Time Clock Software
6. How to Make 2014 the Year Your Agency Becomes More Efficient, Improves Communication and Goes Mobile with Online Services from Aladtec
7. National Energy Technologies Announces the Addition of a Revolutionary New Efficient Motor
8. Los Angeles Hair Transplant Surgeon Doubles the Number of Grafts in FUE Hair Restorations Producing More Efficient FUE Hair Transplantation
9. More Efficient Way to Grow Heart Muscle from Stem Cells Could Yield New Regenerative Therapies
10. H7N9 influenza virus not adapted to efficient human-to-human transmission
11. Couple Chooses Endless Pool for Their Energy Efficient Home
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Efficient analysis of small quantity of cells improves chances to understand disease
(Date:2/9/2016)... St. Petersburg, FL (PRWEB) , ... February 09, 2016 , ... Shark Finds ... of a new DRTV campaign with GRIP-DRY. , GRIP-DRY is a newly patented product that ... carts. Golfers who play in the wet and early morning dew or right after a ...
(Date:2/8/2016)... ... ... CURE Media Group , the nation’s leading digital and print media ... event , which will annually honor individuals making heroic contributions in the field of ... Heroes Awards nomination process is officially open through February 17 for patients, caregivers ...
(Date:2/8/2016)... Bethlehem, PA (PRWEB) , ... February 08, 2016 ... ... announce expanded authorization with BASF Human Nutrition into the Food & Beverage ... BSI has been BASF’s channel partner throughout Canada and USA geographies east ...
(Date:2/8/2016)... ... February 08, 2016 , ... Stephanie Hebert Insurance Agency, serving ... a new charity campaign. As part of their ongoing community involvement program, funds ... belief that children deserve a voice, and in the spirit of neighbors helping ...
(Date:2/8/2016)... ... ... A man who has struggled to quit smoking, a man who has struggled with hair ... solutions to his problems – and he did. Now Nabat, a serial entrepreneur featured as ... breakthrough inventions to the world and better people's lives. His own experience with nicotine addiction ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016 CBG Technologies, a U.S. ... Solvent Recycling Systems, specifically designed for precision parts ... new and existing vapor degreasers, parts washers and ... through continuous recycling and recovers 100% of the ... --> Precision parts manufacturers benefit from ...
(Date:2/8/2016)... 2016  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) ... quarter and year-end 2015 results after the Nasdaq market ... host a live conference call and webcast to discuss ... afternoon, February 11, 2016 at 4:30 p.m. Eastern Time ... --> http://www.neurocrine.com . --> Participants can ...
(Date:2/8/2016)... , Feb. 8, 2016  Echo ... medical device company focused on non-invasive continuous ... announced today announced that it will host ... February 17, 2015 at 9:00 a.m. Eastern ... discuss its corporate strategy, advancements in its ...
Breaking Medicine Technology: