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Efficacy of FluMist(R) in Children Highlighted at Pediatric Academic Societies Meeting
Date:5/5/2008

uMist, efficacy against matched strains was 58 percent, and efficacy increased to 74 percent for those receiving two doses. In the second season of the study, both groups received a single dose of FluMist (per recommendations) and no difference in efficacy was seen (efficacies of 65 percent and 74 percent, respectively). Runny nose/nasal congestion and cough were the most frequently reported events. No events were significantly increased in FluMist recipients; cough was significantly decreased. This double-blind, placebo controlled study, led by Drs. Bracco and Farhat of the Federal University of San Paulo, Brazil, was conducted at 35 sites in the Southern Hemisphere during the 2001 and 2002 influenza seasons.

Dr. Ambrose stated: "Previously unvaccinated children under nine years of age are recommended to receive two doses of influenza vaccine, but studies have shown that less than 50 percent of these children actually receive the second dose. Our trial shows clear evidence that receiving the second dose of FluMist provides more robust protection. However, we are also encouraged that there was still protection for those that received one dose."

Duration of Influenza Protection Using Nasal Spray Flu Vaccine

In a second study, researchers at MedImmune examined data from four previous clinical trials of children between six months (1) and 18 years of age and found that children who were given FluMist had a comparable level of protection through 12 months after vaccination.

"The data on FluMist's duration of protection provide comfort for providers and parents who wish to vaccinate children in late summer or early fall," said Ambrose.

About FluMist

FluMist is a live attenuated influenza virus vaccine indicated for active immunization of individuals two to 49 years of age against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine.

FluMist is contraindicated in individuals with histor
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SOURCE MedImmune
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