Navigation Links
Effects of stopping alcohol consumption on subsequent risk of esophageal cancer
Date:9/13/2012

Cancer of the oesophagus is becoming more common in Europe and North America. Around 7,800 people in the UK are diagnosed each year. The exact causes of this cancer aren't fully understood. It appears to be more common in people who have long-term acid reflux (backflow of stomach acid into the oesophagus). Other factors that can affect the risk of developing cancer of the oesophagus include:

  • Gender It is more common in men than in women.
  • Age The risk of developing oesophageal cancer increases as we get older. It occurs most commonly in people over 45.
  • Smoking The longer a person smokes and the more tobacco they smoke, the greater the risk.
  • Alcohol Drinking a lot of alcohol over a long period of time increases your risk, especially if you smoke too.
  • Diet Having a diet low in fresh fruit and vegetables is linked to an increased risk of oesophageal cancer.
  • Obesity Being overweight is associated with a higher risk. This is thought to be because long-term acid reflux is more common in people who are overweight.

This paper looks at the effect of giving up alcohol on the risk of oesophageal cancer: it is based on 17 studies providing such information, 9 of which provided data for a meta-analysis. The authors conclude that an alcohol-related increased risk of oesophageal cancer is reversible following giving up alcohol, taking up to 16 years to return to the risk level for non-drinkers. The authors estimate that about one-half of the reduction in risk of cancer may occur within in a much shorter time, perhaps within about 4 or 5 years.

Forum reviewers considered this to be a well-done analysis. Forum members emphasized, as did the authors, a number of limitations of the study. Adjustments for smoking may not have been adequate: most upper aero-digestive cancers show a strong interaction between smoking and alcohol consumption in relation to cancer risk, (there is little effect of moderate alcohol consumption among non-smokers found in studies).

Further, large differences in the alcohol-cancer association were shown in this study for different geographical regions (some associations being much higher in Asia than in Europe or North America), but such differences were not adjusted for in the main analyses. The fact that the authors of this paper did not have data permitting the separation of ex-drinkers and never drinkers (both groups being included in the "non-drinker" category), and their inability to judge the effects of the baseline pattern of drinking (regular versus binge drinking), may also be limitations to the interpretation of their results. Adjustment for such factors may have influenced the effects of stopping drinking on subsequent cancer risk, and markedly changed the calculated effects on the numbers of cancers prevented worldwide.

In any case, the fact that cessation of drinking may reduce the risk of oesophageal cancer is of importance. Other studies suggest further that reducing the amount of alcohol consumed to moderate levels rather than the complete cessation of drinking, may be associated with lowering of cancer risk among non-smokers, and low-level regular alcohol intake has been shown to have beneficial health effects on cardiovascular disease, diabetes, and other medical conditions.


'/>"/>
Contact: R Curtis Ellison
ellison@bu.edu
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Young girls more likely to report side effects after HPV vaccine
2. Preteens More Likely to Report HPV Vaccine Side Effects
3. Breast cancer patients suffer treatment-related side effects long after completing care
4. Breast Cancer Treatment Side Effects May Last for Years
5. Baldness Drug May Cause Sexual Side Effects: FDA
6. Study examines adverse effects among different radiation therapies for prostate cancer
7. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
8. Moffitt researcher publishes book on nutritional management of cancer treatment effects
9. Researchers see BPA effects in monkey mammary glands
10. Many Primary Care Docs Dont Know Long-Term Effects of Chemo: Survey
11. Dartmouth researchers investigate the cognitive effects of athlete head impacts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... “Vintage and Harvest A ... minister and college Bible teacher residing in North Carolina with his wife, Anna Marie. ... blessed them with six grandchildren. David is also the author of “Shadow and Substance.” ...
(Date:3/23/2017)... WA (PRWEB) , ... March 23, 2017 , ... In ... and now estimates that there could be four million Zika-related cases in the Americas ... date with numbers of US cases reported per year skyrocketing to an estimated 329,000. ...
(Date:3/23/2017)... ... March 23, 2017 , ... Demonstrating their commitment to improving ... health departments have been awarded national accreditation through the Public Health Accreditation ... expanding network of communities across the nation whose health departments meet rigorous national ...
(Date:3/23/2017)... ... ... The IoT (Internet of Things) is revolutionizing the way the world operates. ... and individual consumers alike. Laboratories can maximize their profit margin by increasing throughput. ... trillion to $11 trillion dollars by the year 2025. McKinsey expects the IoT to ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... and businesses of the Norwalk and Vermillion areas, celebrates the newest charity ... is a nonprofit, community-based substance abuse prevention and peer recovery support organization ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)...  Ethicon* today announced the completion of its ... medical device company that manufactures and markets the ... of Gastroesophageal Reflux Disease (GERD). This acquisition is ... of minimally invasive options for patients suffering from ... the transaction have not been disclosed. ...
(Date:3/23/2017)... A research report by Mordor Intelligence ... reach USD 7.2 billion by the end of 2021 and ... procedure in which a sample is preserved prior to its ... since the methods are often allowing repeated testing. The report ... shared procedures in the lab. In many life science labs, ...
(Date:3/23/2017)... DENVER , March 23, 2017  Drug ... pain medication misuse and deadly overdoses. A new ... Health Solutions, www.cordantsolutions.com , reports more detailed ... tests, which can potentially improve therapy adherence, patient ... The Cordant Comprehensive Oral fluid Rx Evaluation ...
Breaking Medicine Technology: