Navigation Links
Effects of smoking linked to accelerated aging protein
Date:2/5/2009

A University of Iowa study is apparently the first to make a connection between a rare, hereditary premature aging disease and cell damage that comes from smoking. The study results point to possible therapeutic targets for smoking-related diseases.

The investigation found that a key protein that is lost in Werner's syndrome is decreased in smokers with emphysema, and this decrease harms lung cells that normally heal wounds. The findings appear in the Feb. 6 issue of the American Journal of Respiratory and Critical Care Medicine.

While people know that smoking is bad for health, not all the mechanisms by which smoke damages the body are fully understood, said Toru Nyunoya, M.D., assistant professor of internal medicine at the University of Iowa Carver College of Medicine and a pulmonologist with University of Iowa Hospitals and Clinics.

"Smoking can accelerate the aging process and shorten the lifespan by an average of more than 10 years. We focused on what happens within the lungs because of the similar aging effects, including atherosclerotic diseases and cancer, seen in people with Werner's syndrome and people who smoke," said Nyunoya, whose study was based in the lab of senior author Gary Hunninghake, M.D., University of Iowa professor of internal medicine and a researcher with the Iowa City Veterans Affairs Medical Center.

People with Werner's syndrome begin aging rapidly after adolescence and typically die from cancer or heart disease in their 40s or 50s. The condition is different from progeria (Hutchinson-Gilford syndrome), which causes even earlier premature aging and death at about age 13. Werner's syndrome affects an estimated one in 200,000 people in the United States and is more common in Japan, where up to one in 20,000 individuals are affected.

"Werner's syndrome involves a genetic mutation that causes a deficiency in what's known as Werner's syndrome protein. The protein normally helps repa
'/>"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-335-6660
University of Iowa
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Zinc May Counter Effects of Alcohol in Early Pregnancy
2. Green tea may negate the effects of a common cancer therapy
3. Green Tea May Negate the Effects of a Common Cancer Therapy
4. Driving under the influence (of stress): Regional effects of 9/11 attacks on driving
5. Concussions Effects May Linger for Decades
6. LegalView Updates Avandia Information Portal With New Articles Detailing Potentially Dangerous Side Effects
7. Hallucinations Are Rare Side Effects of ADHD Medications
8. Blocking toxic effects could make clot-buster safer
9. First Study to Test Real-World Effects of Stun Gun Use Raises Questions about Safety
10. Sleep disordered breathing and obesity: Independent effects, causes
11. Dr. Sherrell Aston Addresses the Popularity of Dermal Fillers and Possible Long Term Side Effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... HealthDay Reporter , MONDAY, July 28, 2014 (HealthDay ... may be able to take hormone replacement therapy soon after ... to a new study. Previous studies, including the large-scale ... effects on the heart. But, many of those women were ... past menopause. In this new study, researchers wanted ...
(Date:7/29/2014)... Kelly and Zhi Sheng , assistant professors ... recently received a grant from the Commonwealth Health ... effort that may lead to new treatment approaches. , ... , The grant will fund a two-year project to ... the BRCA1 gene. This type of cancer often has ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The global ... 9,542.3 million by 2020, growing at an estimated CAGR ... new study by Grand View Research, Inc. Introduction of ... devices by the geriatric population, along with increase in ... the major drivers of this market. In addition, presence ...
(Date:7/29/2014)... July 29, 2014 On Friday, the ... declaring the week of October 12-18, 2014, as "National ... management in improving healthcare outcomes for patients. The resolution ... John Boozman (R-AR), with support by the Case Management ... to honor case management professionals for their contributions to ...
(Date:7/29/2014)... “Our years of experience with ... to insulate their homes properly simply due to ... heat transfer and conduction,” Clean Crawls says in ... released an article explaining exactly how heat ... bills. , To contact Clean Crawls for their ...
Breaking Medicine News(10 mins):Health News:Early Hormone Therapy May Be Safe for Women's Hearts 2Health News:Early Hormone Therapy May Be Safe for Women's Hearts 3Health News:Scientists to study hereditary breast cancer to find BRCA1 treatment 2Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 2Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 3Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 4Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 5Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 6Health News:CMSA Supports National Case Management Week Resolution Introduced in US Senate 2Health News:What’s The Point of Insulation? Clean Crawls Explains The Dangers of Heat Transfer in Recently Released Article 2
... men generally have lower prostate specific antigen levels than men ... the PSA test may not be as good at identifying ... 2,800 men with no evidence of prostate cancer. Results showed ... across all age groups and throughout all races. A study ...
... is effective in reducing the risk of death following a ... attack // find researchers according to latest research. ,In ... reviparin on the composite outcome of death, heart attack, and ... was reduced from 11 percent of patients in the placebo ...
... broiled fish, such as tuna, may lower stroke risk ... adults 65 and older. Study participants answered food-frequency questionnaires ... years. ,Results showed 626 of the participants experienced ... broiled or baked fish one- to four-times per week ...
... with a long-acting beta2-agonist (formoterol) can actually provide significant ... high doses of inhaled steroid, say researchers according to ... of various combinations of medicine on asthma symptoms in ... were analyzed. The patients were divided into three treatment ...
... over whether hormone replacement therapy is safe and effective ... the pros and cons of this controversial therapy. ... five years. All the women studied were 50 years ... others did not.Results showed women free of menopausal symptoms ...
... The use of alternative or complementary therapies have increased ... people using // at least one form of alternative ... biofeedback, yoga, hypnosis, acupuncture, chiropractic care, and high-dose vitamins. ... their own survey taken in 1997 to the National ...
Cached Medicine News:
(Date:7/29/2014)... , July 29, 2014 Today, Frost ... Frost & Sullivan Best Practices Award for Customer ... a cloud-based platform that connects digital health application ... as providers, pharmaceutical companies, prevention and wellness companies, ... Each year, Frost & Sullivan presents ...
(Date:7/29/2014)...   , First patient begins treatment ... safety of MSB0010718C in patients with metastatic Merkel cell carcinoma ... cancer lacking effective treatments   MSB0010718C is also currently ... for the treatment of solid tumors that aims to recruit ... of Merck KGaA, Darmstadt, Germany , today ...
(Date:7/28/2014)... (NASDAQ: LMNX ) today announced financial results ... and operating highlights include the following: , ... percent increase over the second quarter of 2013. ... 9 percent increase over the second quarter of 2013.  ... which included 148 LX systems, 96 MAGPIX systems, and ...
Breaking Medicine Technology:Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 2Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 3Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 4EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 2EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 3EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 4EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 5Luminex Corporation Reports Second Quarter 2014 results 2Luminex Corporation Reports Second Quarter 2014 results 3Luminex Corporation Reports Second Quarter 2014 results 4Luminex Corporation Reports Second Quarter 2014 results 5Luminex Corporation Reports Second Quarter 2014 results 6Luminex Corporation Reports Second Quarter 2014 results 7Luminex Corporation Reports Second Quarter 2014 results 8Luminex Corporation Reports Second Quarter 2014 results 9Luminex Corporation Reports Second Quarter 2014 results 10Luminex Corporation Reports Second Quarter 2014 results 11Luminex Corporation Reports Second Quarter 2014 results 12Luminex Corporation Reports Second Quarter 2014 results 13Luminex Corporation Reports Second Quarter 2014 results 14Luminex Corporation Reports Second Quarter 2014 results 15Luminex Corporation Reports Second Quarter 2014 results 16Luminex Corporation Reports Second Quarter 2014 results 17
... Reportlinker.com announces that a new market research ... Cancer Pain Therapeutics - ... http://www.reportlinker.com/p0546769/Cancer-Pain-Therapeutics---Pipeline-Assessment-and-Market-Forecasts-to-2017.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology ... Assessment and Market Forecasts to 2017 ...
... YORK, June 1, 2011 ... market research report is available ... Interventional Neurology - ... and Market Forecasts to 2017 ...
Cached Medicine Technology:Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 6Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 7Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 8Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 9Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 10Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 2Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 3Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 4Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 5Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 6Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 7Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 8Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 9Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 10Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 11Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 12
... order tips. Each box contains 10,000 tips ... in easy-to-open, re-sealable Bulk Packs of 200 ... with a tamper-proof strip which can easily ... Diamond Tips. Bulk Packs are closed using ...
10 L, Bulk Recommended for 2, 5 and 10 L pipettes....
10 L, Bulk Recommended for 2, 5, 10 L pipettes....
... Theken eDISC is a revolutionary advancement in ... assess and manage their patients. The eDISC's ... the eDISC from 1st and 2nd generation ... loads of the lumbar spine, the eDISC ...
Medicine Products: