Navigation Links
Effects of smoking linked to accelerated aging protein
Date:2/5/2009

A University of Iowa study is apparently the first to make a connection between a rare, hereditary premature aging disease and cell damage that comes from smoking. The study results point to possible therapeutic targets for smoking-related diseases.

The investigation found that a key protein that is lost in Werner's syndrome is decreased in smokers with emphysema, and this decrease harms lung cells that normally heal wounds. The findings appear in the Feb. 6 issue of the American Journal of Respiratory and Critical Care Medicine.

While people know that smoking is bad for health, not all the mechanisms by which smoke damages the body are fully understood, said Toru Nyunoya, M.D., assistant professor of internal medicine at the University of Iowa Carver College of Medicine and a pulmonologist with University of Iowa Hospitals and Clinics.

"Smoking can accelerate the aging process and shorten the lifespan by an average of more than 10 years. We focused on what happens within the lungs because of the similar aging effects, including atherosclerotic diseases and cancer, seen in people with Werner's syndrome and people who smoke," said Nyunoya, whose study was based in the lab of senior author Gary Hunninghake, M.D., University of Iowa professor of internal medicine and a researcher with the Iowa City Veterans Affairs Medical Center.

People with Werner's syndrome begin aging rapidly after adolescence and typically die from cancer or heart disease in their 40s or 50s. The condition is different from progeria (Hutchinson-Gilford syndrome), which causes even earlier premature aging and death at about age 13. Werner's syndrome affects an estimated one in 200,000 people in the United States and is more common in Japan, where up to one in 20,000 individuals are affected.

"Werner's syndrome involves a genetic mutation that causes a deficiency in what's known as Werner's syndrome protein. The protein normally helps repair DNA damage," Nyunoya said. "Smoking does not appear to cause the same mutation, but our study showed that it does decrease Werner's syndrome protein."

To reach that conclusion, the investigators compared lung fibroblasts (a type of cell) taken from nonsmokers without lung disease and patients with a heavy smoking history and severe emphysema. Fibroblasts from the smokers with emphysema had lost their ability to divide or grow, confirming that smoking habits cause cell aging. The cells also had lower levels of Werner's syndrome protein, compared to cells from nonsmokers.

The team also applied cigarette smoke extract to cultured lung fibroblasts taken from nonsmokers. They saw that Werner's syndrome protein expression was decreased, and the cells had lost their ability to repair wounds. In contrast, when the team caused the lung fibroblasts in petri dishes to overexpress Werner's syndrome protein, it had a protective effect and helped resist the damaging effects of cigarette smoke.

"Overall, our study may support efforts to target Werner's syndrome protein for use in developing treatments for smoking-related conditions such as emphysema," Nyunoya said.

The team will next use mouse models to further study the effects of smoking on Werner's syndrome protein.


'/>"/>
Contact: Becky Soglin
becky-soglin@uiowa.edu
319-335-6660
University of Iowa
Source:Eurekalert

Related medicine news :

1. Zinc May Counter Effects of Alcohol in Early Pregnancy
2. Green tea may negate the effects of a common cancer therapy
3. Green Tea May Negate the Effects of a Common Cancer Therapy
4. Driving under the influence (of stress): Regional effects of 9/11 attacks on driving
5. Concussions Effects May Linger for Decades
6. LegalView Updates Avandia Information Portal With New Articles Detailing Potentially Dangerous Side Effects
7. Hallucinations Are Rare Side Effects of ADHD Medications
8. Blocking toxic effects could make clot-buster safer
9. First Study to Test Real-World Effects of Stun Gun Use Raises Questions about Safety
10. Sleep disordered breathing and obesity: Independent effects, causes
11. Dr. Sherrell Aston Addresses the Popularity of Dermal Fillers and Possible Long Term Side Effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... ... ... a legally blind and certified personal trainer is helping to develop a weight loss fitness ... to fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
Breaking Medicine Technology: