Navigation Links
Effects of smoking linked to accelerated aging protein

A University of Iowa study is apparently the first to make a connection between a rare, hereditary premature aging disease and cell damage that comes from smoking. The study results point to possible therapeutic targets for smoking-related diseases.

The investigation found that a key protein that is lost in Werner's syndrome is decreased in smokers with emphysema, and this decrease harms lung cells that normally heal wounds. The findings appear in the Feb. 6 issue of the American Journal of Respiratory and Critical Care Medicine.

While people know that smoking is bad for health, not all the mechanisms by which smoke damages the body are fully understood, said Toru Nyunoya, M.D., assistant professor of internal medicine at the University of Iowa Carver College of Medicine and a pulmonologist with University of Iowa Hospitals and Clinics.

"Smoking can accelerate the aging process and shorten the lifespan by an average of more than 10 years. We focused on what happens within the lungs because of the similar aging effects, including atherosclerotic diseases and cancer, seen in people with Werner's syndrome and people who smoke," said Nyunoya, whose study was based in the lab of senior author Gary Hunninghake, M.D., University of Iowa professor of internal medicine and a researcher with the Iowa City Veterans Affairs Medical Center.

People with Werner's syndrome begin aging rapidly after adolescence and typically die from cancer or heart disease in their 40s or 50s. The condition is different from progeria (Hutchinson-Gilford syndrome), which causes even earlier premature aging and death at about age 13. Werner's syndrome affects an estimated one in 200,000 people in the United States and is more common in Japan, where up to one in 20,000 individuals are affected.

"Werner's syndrome involves a genetic mutation that causes a deficiency in what's known as Werner's syndrome protein. The protein normally helps repair DNA damage," Nyunoya said. "Smoking does not appear to cause the same mutation, but our study showed that it does decrease Werner's syndrome protein."

To reach that conclusion, the investigators compared lung fibroblasts (a type of cell) taken from nonsmokers without lung disease and patients with a heavy smoking history and severe emphysema. Fibroblasts from the smokers with emphysema had lost their ability to divide or grow, confirming that smoking habits cause cell aging. The cells also had lower levels of Werner's syndrome protein, compared to cells from nonsmokers.

The team also applied cigarette smoke extract to cultured lung fibroblasts taken from nonsmokers. They saw that Werner's syndrome protein expression was decreased, and the cells had lost their ability to repair wounds. In contrast, when the team caused the lung fibroblasts in petri dishes to overexpress Werner's syndrome protein, it had a protective effect and helped resist the damaging effects of cigarette smoke.

"Overall, our study may support efforts to target Werner's syndrome protein for use in developing treatments for smoking-related conditions such as emphysema," Nyunoya said.

The team will next use mouse models to further study the effects of smoking on Werner's syndrome protein.

Contact: Becky Soglin
University of Iowa

Related medicine news :

1. Zinc May Counter Effects of Alcohol in Early Pregnancy
2. Green tea may negate the effects of a common cancer therapy
3. Green Tea May Negate the Effects of a Common Cancer Therapy
4. Driving under the influence (of stress): Regional effects of 9/11 attacks on driving
5. Concussions Effects May Linger for Decades
6. LegalView Updates Avandia Information Portal With New Articles Detailing Potentially Dangerous Side Effects
7. Hallucinations Are Rare Side Effects of ADHD Medications
8. Blocking toxic effects could make clot-buster safer
9. First Study to Test Real-World Effects of Stun Gun Use Raises Questions about Safety
10. Sleep disordered breathing and obesity: Independent effects, causes
11. Dr. Sherrell Aston Addresses the Popularity of Dermal Fillers and Possible Long Term Side Effects
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid speed at which ... age, more care is needed, especially with Alzheimer’s, dementia and other cognitive conditions ... overworked. The forgotten part of this equation: 80 percent of medical care occurs ...
(Date:11/27/2015)... ... November 27, 2015 , ... Lizzie’s Lice Pickers just announced a ... customers 10% off of their purchase of lice treatment product. In addition, customers will ... to a company spokesperson. “Finding lice is a sure way to ruin the holidays, ...
(Date:11/27/2015)... Fairfax, VVA (PRWEB) , ... November 27, 2015 ... ... (RBMA) motto of progress through sharing, the 2016 Building Better Radiology ... campaigns. The conference will begin on Sunday, March 6, 2016, at Caesars Palace ...
(Date:11/27/2015)... ... 27, 2015 , ... Keeping in mind challenges faced by ... wellness consultation, has collaborated with a leading web-based marketplace for extra-curricular activities for ... parents and bring advice from parenting experts within their reach. As a part ...
(Date:11/27/2015)... ... 27, 2015 , ... Avid collector, Andrew Hawley from Vintage Rock Posters, announces ... This is one of Joplin's most famous and beautiful concert posters. The concert was ... in Ann Arbor. The According to Hawley, "It is hard to believe that Joplin's ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... , Pays-Bas, November 27, 2015 ... l,immunothérapie au traitement photodynamique au Bremachlorin contre le ... nouvelle approche consistant à combiner l,immunothérapie au traitement ...    --> Une nouvelle approche ... Bremachlorin contre le cancer avancé.    ...
(Date:11/27/2015)... , November 27, 2015 ... set to go online. The potential to save costs, ... vast and far from fully exploited as yet. Here, ... health records, either via mobile tablet or directly at ... --> ) -->      ...
(Date:11/27/2015)... , Niederlande, November 27, 2015 ... Bremachlorin-Therapie bei fortgeschrittenem Krebs.   --> ... bei fortgeschrittenem Krebs.   --> ... bei fortgeschrittenem Krebs.   Clinical Cancer ... --> Clinical Cancer Research vom 6. ...
Breaking Medicine Technology: