Navigation Links
Effects of disease severity on autobiographical memory in semantic dementia revealed in new study
Date:4/2/2009

Milan, Italy, 2 April 2009 - In a study conducted by the Laboratory of Neuropsychology of the Universit de Caen Basse-Normandie and published by Elsevier in the April 2009 issue of Cortex (http://www.elsevier.com/locate/cortex), researchers studied for the first time autobiographical memory in a group of semantic dementia (SD) patients according to disease progression. They highlighted that at early stages of the disease those patients could recall recent memories, but also lasting memories from their youth which tend to disappear as dementia evolves. Mechanisms at the root of this autobiographical memory impairment result from storage deficits combined with faulty retrieval strategies.

Semantic dementia is a neurodegenerative disease characterized by a semantic memory breakdown; this type of memory concerns meanings and understandings about the world, e.g. "Paris is the capital of France" as well as personal semantics. Despite their important semantic deficits, these patients show preserved abilities concerning daily living activities and can recall recent specific personal events, with episodic details, at least at the beginning of the disease. This observation is interesting because it suggests that episodic autobiographical memory referring to both recent and old memories, particular to each individual at the source of personal continuity over time, is preserved in early SD.

Two groups of 7 patients each were studied. One group consisted of SD patients with mild cognitive impairment and the other consisted of patients with moderate cognitive impairment. An autobiographical memory test, called the TEMPau task, was used which assessed general and specific memories across the entire lifetime. Results indicated for the mild subgroup, preserved performances for the most recent time period and a relative preservation of a reminiscence bump, which concerns the surge of vivid and important self-defining episodic memories acquired between 18 and 30 years. In the moderate subgroup, performances were impaired whatever the time period including the most recent one. These results highlight that, with disease severity, episodic memories tend to vanish regardless of their recency.

The implications of these findings are particularly interesting from both theoretical and clinical viewpoints. First, they confirm that the relative preservation of episodic memories in early SD is not just a matter of recency, as frequently proposed. Second, they should provide new avenues on the development of specific methods of rehabilitation of new and old semantic concepts based on episodic autobiographical memory from the last 12 months and the reminiscence bump.


'/>"/>

Contact: Valeria Brancolini
v.brancolini@elsevier.com
39-028-818-4260
Elsevier
Source:Eurekalert

Related medicine news :

1. Cooperative Exchange Meeting to Tackle Stimulus Package Effects
2. Cleveland Trials Set In Nephrogenic Systemic Fibrosis (NSF) Gadolinium MRI Side Effects Cases
3. UIC researchers measure health effects of Chicagos waterways
4. Cleveland Clinic Launches Ground-Breaking Wellness Program To Reverse Effects of Common Chronic Diseases
5. The Effects of Probiotics on the Aging Digestive Tract to be Presented at Nutracon 2009
6. Potential atherosclerosis drug exhibits no harmful side-effects in liver
7. Cleveland Clinic Launches Ground-Breaking Wellness Program To Reverse Effects of Common Chronic Diseases
8. Effects of smoking linked to accelerated aging protein
9. Zinc May Counter Effects of Alcohol in Early Pregnancy
10. Green tea may negate the effects of a common cancer therapy
11. Green Tea May Negate the Effects of a Common Cancer Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... ... With the FCPX LUT: Summer pack from Pixel Film Studios, ... is a Lookup Table that contains a mathematical formula for modifying an image. The ... manipulating each pixel, LUT's can change each color range differently, it gives the user ...
(Date:2/6/2016)... ... February 06, 2016 , ... Research has ... helps to reduce the frequency and level of relapse. , At ... Identity and Purpose,” will explore the critical tasks of the recovery phase and ...
(Date:2/5/2016)... ... ... Love is in the air at King Kullen! The local grocer is ... staple for Valentine’s Day is a must-have, and can be picked up with all ... are long-stem roses available, but also other flower bouquets, elegantly wrapped and ready to ...
(Date:2/5/2016)... ... February 05, 2016 , ... Today, the Whole-Food Warrior TV ... the much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian cuisine, will stream ... Each week, on his weekly Whole-Food Warrior TV show, Frank Davis highlights Whole-Food Warriors ...
(Date:2/5/2016)... ... 2016 , ... The event is being held on April 7, 2016 from ... Triumph Over Parkinson’s will fund nearly $100,000 for research for the care and cure ... disease and is the architect of this informative event to raise awareness and funds ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016 Mettler-Toledo International Inc. (NYSE: ... 2015.  Provided below are the highlights: , ... compared with the prior year.  Reported sales decreased 3% ... quarter. , Net earnings per diluted share as ... prior- year period.  Adjusted EPS was $4.65, an increase ...
(Date:2/4/2016)...  AMRI (NASDAQ:  AMRI) today announced that Anthony J. ... of Pfizer Global Supply, has been elected to the AMRI ... addition, the Company announced that Mr. Gabe Leung , ... has retired from the AMRI Board of Directors in order ... ventures.  William S. Marth , President and ...
(Date:2/4/2016)... , Feb. 4, 2016 SONIFI™ ... technology solutions, today announced that MonteCedro, an innovative ... Living Engagement System. The system provides a simple ... residents access through a tablet PC. ... resident engagement system provides access to a wide ...
Breaking Medicine Technology: