Navigation Links
Effects of disease severity on autobiographical memory in semantic dementia revealed in new study
Date:4/2/2009

Milan, Italy, 2 April 2009 - In a study conducted by the Laboratory of Neuropsychology of the Universit de Caen Basse-Normandie and published by Elsevier in the April 2009 issue of Cortex (http://www.elsevier.com/locate/cortex), researchers studied for the first time autobiographical memory in a group of semantic dementia (SD) patients according to disease progression. They highlighted that at early stages of the disease those patients could recall recent memories, but also lasting memories from their youth which tend to disappear as dementia evolves. Mechanisms at the root of this autobiographical memory impairment result from storage deficits combined with faulty retrieval strategies.

Semantic dementia is a neurodegenerative disease characterized by a semantic memory breakdown; this type of memory concerns meanings and understandings about the world, e.g. "Paris is the capital of France" as well as personal semantics. Despite their important semantic deficits, these patients show preserved abilities concerning daily living activities and can recall recent specific personal events, with episodic details, at least at the beginning of the disease. This observation is interesting because it suggests that episodic autobiographical memory referring to both recent and old memories, particular to each individual at the source of personal continuity over time, is preserved in early SD.

Two groups of 7 patients each were studied. One group consisted of SD patients with mild cognitive impairment and the other consisted of patients with moderate cognitive impairment. An autobiographical memory test, called the TEMPau task, was used which assessed general and specific memories across the entire lifetime. Results indicated for the mild subgroup, preserved performances for the most recent time period and a relative preservation of a reminiscence bump, which concerns the surge of vivid and important self-defining episodic memories acquired between 18 and 30 years. In the moderate subgroup, performances were impaired whatever the time period including the most recent one. These results highlight that, with disease severity, episodic memories tend to vanish regardless of their recency.

The implications of these findings are particularly interesting from both theoretical and clinical viewpoints. First, they confirm that the relative preservation of episodic memories in early SD is not just a matter of recency, as frequently proposed. Second, they should provide new avenues on the development of specific methods of rehabilitation of new and old semantic concepts based on episodic autobiographical memory from the last 12 months and the reminiscence bump.


'/>"/>

Contact: Valeria Brancolini
v.brancolini@elsevier.com
39-028-818-4260
Elsevier
Source:Eurekalert

Related medicine news :

1. Cooperative Exchange Meeting to Tackle Stimulus Package Effects
2. Cleveland Trials Set In Nephrogenic Systemic Fibrosis (NSF) Gadolinium MRI Side Effects Cases
3. UIC researchers measure health effects of Chicagos waterways
4. Cleveland Clinic Launches Ground-Breaking Wellness Program To Reverse Effects of Common Chronic Diseases
5. The Effects of Probiotics on the Aging Digestive Tract to be Presented at Nutracon 2009
6. Potential atherosclerosis drug exhibits no harmful side-effects in liver
7. Cleveland Clinic Launches Ground-Breaking Wellness Program To Reverse Effects of Common Chronic Diseases
8. Effects of smoking linked to accelerated aging protein
9. Zinc May Counter Effects of Alcohol in Early Pregnancy
10. Green tea may negate the effects of a common cancer therapy
11. Green Tea May Negate the Effects of a Common Cancer Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg ... Legal Elite. The attorneys chosen by their peers for this recognition are considered among ... Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite Hall ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, ... journal articles published in Emergency Medicine Practice and Pediatric Emergency Medicine ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology: