Navigation Links
Effects of Parkinson's-disease mutation reversed in cells
Date:8/16/2013

emical transformation as a result. PINK1 uses ATP as a substrate, and the chemical reaction helps PINK1 in turn drive the activation of another enzyme, called Parkin.

Both of these enzymes are among a small number that previously have been strongly linked to Parkinsons disease. PINK1 and Parkin act together to monitor the health of mitochondria, and help trigger repair or disposal of damaged mitochondria within the cells, thereby promoting cell survival.

Therapeutic approaches for enhancing the activity of PINK1 had not been considered, because scientists had not conceived of the idea of developing a new substrate for the enzyme, Shokat said.

We found that a small molecule, called KTP, speeds chemical reactions catalyzed by PINK1 better than ATP, the natural substrate. That kind of better-than-natural response is essentially unheard of.

KTP is too big to fit into other kinases, Shokat said, but PINK1 has a larger ATP pocket to hold KTP.

After discovering the potential of KTP, the researchers then determined that kinetin is converted to KTP within cells. Experimentally, kinetin, which can cross blood vessels to get into the brain, has been given by mouth to treat a rare, genetic, neurological disease called familial dysautonomia.


'/>"/>

Contact: Jeffrey Norris
jeff.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mirena Lawsuit News: Bernstein Liebhard LLP Notes Issuance of New Order in New Jersey Mirena Side Effects Litigation
2. Researcher awarded $1.8 million grant to study gender differences in antidepressant effects
3. Mental Health Watchdog Launches Psychiatric Drug Side Effects Database—Search All Drug Regulatory Agency Warnings, Studies & Adverse Reactions Reports
4. Pradaxa Lawsuit Lawyers at Wright & Schulte LLC Disturbed by New Study Finding that Pradaxa Users Face Significantly Higher Risk of Bleeding Side-Effects
5. Research shows negative effects of half-siblings
6. Latest Yaz, Yasmin Lawsuits Alleging Blood-Clotting Side Effects: Resource4thePeople Reports Consolidated Cases Continue to Be Opened, Settled and Dismissed
7. Necrostatin-1 counteracts aluminums neurotoxic effects
8. Understanding the effects of genes on human traits
9. New Update on Alleged Transvaginal Mesh Complications Lawsuits: First Federal Trial Involving Allegations of Serious Side Effects from C.R. Bard Mesh Scheduled to Begin
10. Frequent Urination can be Terminated by Taking Herbal Medicine with No Side Effects, Highlights Wuhan Dr. Lee's TCM Clinic
11. A lifespan-extending drug has limited effects on aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 2014 Timothy, InstaKNOT’s 4-year-old ... firefighters, showing that you are never too young to ... firefighters Tracey and Carl at the 2013 Santa Arriving ... Pompano Beach Chamber of Commerce. Tracey gave Timothy a ... Timothy wear his real fireman’s hat, and extending an ...
(Date:10/30/2014)... 2014 Don Allred Insurance, a leading ... plans for North Carolina residents, is excited to announce ... Holly Hill Mall. The new branch has been up ... customers through all facets of the insurance selection process ... spokesman Scott Allred couldn’t be happier with the timing ...
(Date:10/30/2014)... Portland, OR (PRWEB) October 30, 2014 ... law firm Hodgkinson Street LLC announces new branding ... Hodgkinson Street Mepham . After David Mepham’s promotion ... revitalizes their brand and website to include Mepham’s name ... leading medical malpractice and mediation firm, the decision to ...
(Date:10/30/2014)... 2014 Paramount Rx, a full-service prescription ... efforts to help people save money through its innovative ... for prescription drugs in the new health care system, ... to bridge the relationship between consumers, businesses and the ... challenges people face today with medical costs is the ...
(Date:10/30/2014)... HealthDay Reporter , WEDNESDAY, Oct. ... with prostate cancer who also have certain heart problems may ... new study suggests. , , The therapy in question is called ... reduce levels of male hormones to prevent the growth of ... research, this hormone therapy was linked to triple the risk ...
Breaking Medicine News(10 mins):Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 2Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 3Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 4Health News:Allred Insurance Satellite Office Grand Opening 2Health News:Hodgkinson Street Mepham Rebrands 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3
... Kathleen Doheny HealthDay Reporter , MONDAY, March 19 ... spectrum disorders earn significantly less than what mothers of children ... has found. These moms even earn less than mothers ... with autism earned, on average, less than $21,000 a year, ...
... clearer understanding of glaucoma | Back to top , Glaucoma ... blindness worldwide. In glaucoma patients, the optic nerve, which relays ... the molecular cause of nerve damage is unclear. Dr. Simon ... to understand the earliest events that lead to optic nerve ...
... American children leaving doctors, offices with an attention deficit ... 10 years, according to a new Northwestern Medicine study. ... physicians, have begun treating an increasing number of these ... which was published in the March/April issue of the ...
... HealthDay Reporter , MONDAY, March 19 (HealthDay ... cholesterol, might reduce a bit the risk of developing ... from a large international study that looked at the ... trial included almost 18,000 adults aged 50 or older ...
... University of Granada researchers have developed a software tool ... a person has to suffer a heart disease. In ... risk estimations, i.e. it helps estimating the risk that ... condition. The researchers employed a sample including 3 000 patients. ...
... , SUNDAY, March 18 (HealthDay News) -- Varicose ... can be a sign of a serious medical problem for ... Americans have varicose veins, and about 6 percent have more ... Peter Gloviczki, a vascular surgeon at the Mayo Clinic in ...
Cached Medicine News:Health News:Mothers of Kids With Autism Earn Less, Study Shows 2Health News:Mothers of Kids With Autism Earn Less, Study Shows 3Health News:JCI early table of contents for March 19, 2012 2Health News:JCI early table of contents for March 19, 2012 3Health News:JCI early table of contents for March 19, 2012 4Health News:JCI early table of contents for March 19, 2012 5Health News:JCI early table of contents for March 19, 2012 6Health News:JCI early table of contents for March 19, 2012 7Health News:JCI early table of contents for March 19, 2012 8Health News:JCI early table of contents for March 19, 2012 9Health News:Diagnosis of ADHD on the rise 2Health News:Could Statins Help Prevent Pneumonia? 2Health News:Could Statins Help Prevent Pneumonia? 3Health News:Scientists develop a software tool for estimating heart disease risk 2
(Date:10/30/2014)... 30, 2014 , Extensively hydrolyzed ... milk   Cow milk protein allergy (CMPA) is the leading ... Until now, it has been managed by eliminating milk ... shown that it is possible to help build of ... of children during the first year of life by ...
(Date:10/30/2014)... YORK , Oct. 29, 2014 ... the basis of test type, technology, product, and ... register the highest growth rate in the newborn ... This high growth is attributed to various nations ... is a fundamental instrument used for expanded newborn ...
(Date:10/30/2014)... Hospital stretchers are apparatus used to ... inside or outside of medical infrastructure premises. In ... used for several specialized functions such as hospital ... The hospital stretchers market report studies ... potential of hospital stretchers globally. The hospital stretchers ...
Breaking Medicine Technology:Experts Present Latest Research at Allergy Day 2Experts Present Latest Research at Allergy Day 3NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 2NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 3Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 3
... from the latest 60 series bronchoscopes., ... range, focussing on providing clinicians with ... Olympus has a impressive range of ... in the respiratory tract to meet ...
Fujinon's standard fiberoptic bronchoscope is fully submersible and offers a large image for more comfortable and efficient observation....
... performance fiberoptic imaging from the latest ... improved its fiberscope range, focussing on ... enhanced image performance. Olympus has a ... diagnosis and therapy in the respiratory ...
... The BF-1T40 has been designed with a ... in therapeutic applications. This permits the selection ... those for electrosurgical procedures. In addition, this ... field of view and a bright, high-resolution ...
Medicine Products: