Navigation Links
Effects of High Blood Pressure Drug May Mimic Celiac Disease

FRIDAY, June 22 (HealthDay News) -- A new report suggests that the common blood pressure drug olmesartan (Benicar) can cause symptoms that mimic celiac disease, leading to misdiagnosis and unnecessary treatment.

It's not clear how often people who take the blood pressure-lowering drug will develop the gastrointestinal problems that are similar to those caused by celiac disease. For the moment, though, the side effects appear to be unusual, said Dr. Peter Green, director of the Celiac Disease Center at Columbia University Medical School, who was not involved with the study.

Still, Green noted, his center has seen patients who developed celiac disease-like symptoms while taking olmesartan and some have been quite ill. "One went into kidney failure and needed dialysis," he said.

According to the new study from the Mayo Clinic in Rochester, Minn., 22 patients -- aged 47 to 81, average age 70 -- had symptoms of chronic diarrhea and weight loss of an average of 40 pounds. Fourteen of the patients needed to be hospitalized.

Tests showed that these patients didn't have celiac disease, a condition that causes gastrointestinal problems due to an allergy to gluten, which is found in products such as wheat and rye. However, all of the patients were taking olmesartan.

After they stopped taking the drug, all of the patients' symptoms improved; all but three went on to take other blood pressure medications.

It is not clear why the drug may cause the gastrointestinal symptoms, the study authors noted in the report published online June 21 in the Mayo Clinic Proceedings.

"These patients are usually elderly and have been on the drug for quite some time," said Green. Researchers should continue exploring the issue, he suggested.

While the study uncovered an association between celiac disease-like symptoms and use of olmesartan, it did not prove a cause-and-effect relationship.

"We thought these cases were celiac disease initially because their biopsies showed features very like celiac disease, such as inflammation," study author Dr. Joseph Murray, a Mayo Clinic gastroenterologist, said in a news release from the clinic. "What made them different was they didn't have the antibodies in their blood that are typical for celiac disease."

"It's really an awareness issue. We want doctors to be aware of this issue, so if they see a patient who is having this type of syndrome, they think about medications as a possible association," Murray said. "We've reported an association. What needs to be known next is the science to understand why there is such an association."

More information

For more on celiac disease, visit the U.S. National Library of Medicine.

-- Randy Dotinga

SOURCES: Peter Green, M.D., director, Celiac Disease Center, and professor of clinical medicine, Columbia University Medical School, New York City; Mayo Clinic, news release, June 21, 2012; June 21, 2012, Mayo Clinic Proceedings, online

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Young girls more likely to report side effects after HPV vaccine
2. Preteens More Likely to Report HPV Vaccine Side Effects
3. Breast cancer patients suffer treatment-related side effects long after completing care
4. Breast Cancer Treatment Side Effects May Last for Years
5. Baldness Drug May Cause Sexual Side Effects: FDA
6. Study examines adverse effects among different radiation therapies for prostate cancer
7. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
8. Moffitt researcher publishes book on nutritional management of cancer treatment effects
9. Researchers see BPA effects in monkey mammary glands
10. Many Primary Care Docs Dont Know Long-Term Effects of Chemo: Survey
11. Dartmouth researchers investigate the cognitive effects of athlete head impacts
Post Your Comments:
Related Image:
Effects of High Blood Pressure Drug May Mimic Celiac Disease
(Date:11/25/2015)... ... 25, 2015 , ... The holiday season is jam-packed with ... palates of attendees is of the utmost importance. Whether you are cooking at ... these recipes a try this holiday season. , Turkey Croquettes , ...
(Date:11/25/2015)... ... November 26, 2015 , ... ... European Union (EU), ANDI Pan African Centres of Excellence, and public R&D institutions, ... (UNON) for the opening of the 5th African Network for Drugs and Diagnostics ...
(Date:11/25/2015)... OH (PRWEB) , ... November 25, 2015 , ... Dental ... implants in Cleveland, OH , are invited to attend Dr. Mark Iacobelli’s Advanced Implant ... this year in Cleveland, OH. , As the co-founders of Advanced Implant Mentoring ...
(Date:11/25/2015)... ... 2015 , ... Smiles by Stevens is pleased to announce the ... While many patients are aware of the benefits of Botox® in the treatment of ... suffering with discomfort, soreness, and pain as a result of Jaw Tension, TMJ (temporo-mandibular ...
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I saw a ... “I thought there had to be a convenient and comfortable way to protect them ... enables disabled individuals to safely travel during cold or inclement weather. In doing so, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Research and Markets ( ) ... Future Horizons and Growth Strategies in the Japanese ... Segment Forecasts, Competitive Intelligence, Emerging Opportunities" report ... --> This new 247-page report ... drug monitoring market, including emerging tests, technologies, instrumentation, ...
(Date:11/26/2015)... -- Research and Markets ( ) has announced ... by Type (Dressings, Therapy Devices, Active Wound Care), Application ... and Geography - Global Forecast to 2020" report ... --> The purpose of this report is ... global advanced wound care market. It involves deep dive ...
(Date:11/26/2015)... November 26, 2015 ... the "Radioimmunoassay Market by Type (Reagents ... Industry, Academics, Clinical Diagnostic Labs), Application (Research, ... to 2020" report to their offering. ... the addition of the "Radioimmunoassay Market ...
Breaking Medicine Technology: