Navigation Links
Effective prostate cancer treatment discovery
Date:2/25/2010

Monash University biomedical scientists have identified a new way to treat castrate resistant cells in prostate cancer sufferers the most common cancer in Australian men.

For more than 60 years the main way to treat men with prostate cancer has involved removing the hormones that fuel growth of the cancer cells. Although initially effective this treatment inevitably fails and when the tumour growth resumes, the disease in incurable. The team, from the Prostate & Breast Cancer Research Program, has discovered a way to treat these potentially fatal diseased cells, which remain in a patient after they have undergone hormone treatment.

The findings have been published in the prestigious medical journal PNAS.

Associate Dean, Research Centres & Institutes and co-author Professor Gail Risbridger said the studies provided proof of the controversial concept that estrogens (hormones mainly thought as being important for women) could be good for men and used therapeutically to treat prostate cancer.

"The research showed that drugs that activate one of the two estrogen receptors, causes cell death. Most commonly cell death in patients with prostate cancer is achieved by withdrawing androgens (male hormones) which results in castration," Professor Risbridger said.

"Although the bulk of the tumour is removed by castration, some cells remain and these castrate-resistant cells are the ones that give rise to recurrent incurable disease"

The team used a drug developed to selectively and specifically activate the beta estrogen receptor in the prostate.

"It not only inhibits the growth of prostate cancer but also kills off cancer cells that are resistant to conventional treatment such as androgen deprivation therapy, more commonly known as castration therapy and does so using a mechanism that is different to castration." Professor Risbridger said.

The team made the discovery in animal models, and then suc
'/>"/>

Contact: Samantha Blair
samantha.blair@adm.monash.edu.au
61-399-034-841
Monash University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Shows Sani-Bag+ to be an Effective Microbial Barrier
2. Mammogram Plus MRI Cost-Effective in High-Risk Women
3. Mammogram Plus MRI Seems Cost-Effective in High-Risk Women
4. Two Sepsis Treatments Look Equally Effective
5. New drug for kidney transplant recipients effective in humans
6. Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
7. Charging less for more effective treatments could reduce health care costs while improving health
8. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
9. Neuroimaging study may pave way for effective Alzheimers treatments
10. Gastric Banding Most Effective for Obese Teens
11. Low forms of cyclin E reduce breast cancer drugs effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... Could genetic code determine someone’s coffee habit? ... by researchers at the Harvard T.H. Chan School of ... the Coffee and Caffeine Genetics Consortium and published ... the study—one of several recent HSPH investigations of the ... than 120,000 regular coffee drinkers of European and African ...
(Date:3/28/2015)... Take a bite of warm, gooey pepperoni pizza, ... into the stomach, ready to break down your meal. ... acids run amok, triggering a burning sensation in the ... 60 million Americans have heartburn at least once a ... how it can be stopped. , Heartburn or acid ...
(Date:3/28/2015)... 2015 Thousands of transvaginal mesh ... C.R. Bard, Inc. continue to move forward in ... Southern District of West Virginia, where Bernstein Liebhard ... Plaintiffs’ Steering Committee. According to an Order ... defendants named in those lawsuits leave to amend ...
(Date:3/28/2015)... March 28, 2015 Emergency Medical Care ... care in Manhattan, recently commemorated its three-year anniversary of ... Manhattan. In addition to 24-hour urgent care, Emergency Medical ... , At this time, Emergency Medical Care’s Urgent ... asthma, chest pain, eye injuries, ear infections, fevers, insect ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 An article ... problem which could prove critical to organizations that deal ... a critical aspect of data security, is worsening . ... data security report, every major category out of the ... penetration testing. “With all the craziness that has gone ...
Breaking Medicine News(10 mins):Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 3Health News:Bypass Your Heartburn Worries This Easter With Tylers Coffee 2Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 2Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 3Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 4Health News:Emergency Medical Care Celebrates Three Years of 24/7 Walk-In Urgent Care Services 2Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 2Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 3Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 4
... HealthDay Reporter , MONDAY, Nov. 1 (HealthDay News) -- ... and send phone text messages may lead to learning problems, ... suggests. The research, conducted at the Sleep Disorders Center ... who snuck time on their cell phones, computers and other ...
... MONDAY, Nov. 1 (HealthDay News) -- The success of a ... which are commonly found in nuts, seeds, avocados, and oils ... research suggests. In the study, researchers randomly assigned 17 ... cholesterol levels to either a high-MUFA diet or a low-MUFA ...
... By Amanda Gardner HealthDay Reporter , MONDAY, Nov. ... treated for major depression initially recovered, about half ended up ... And those recurrences were more likely to strike girls ... long time that people are going to revert back to ...
... adenocarcinoma is exceedingly rare in the pediatric population, ... tumors in children and adolescents. While anecdotal reports ... little research has been conducted to link the ... adults. Through an assessment of clinical, tissue-based and ...
... , PITTSBURGH, Nov. 1 Nonsteroidal anti-inflammatory drugs (NSAIDs) ... self-destruct, according to researchers at the University of Pittsburgh ... of Medicine. Their findings, reported in the early online ... Academy of Sciences, could lead to new strategies ...
... When looking for new ways to treat aggressive brain ... leaf and "discovered" the lowly daffodil. A new research ... The FASEB Journal ( http://www.fasebj.org ) offers ... called narciclasine, may be a powerful therapeutic against biologically ...
Cached Medicine News:Health News:Study Finds Teens' Late Night Media Use Comes at a Price 2Health News:Study Finds Teens' Late Night Media Use Comes at a Price 3Health News:Adding Monounsaturated Fats to Diet May Boost Heart Health 2Health News:Half of Teens Treated for Depression Will Relapse: Study 2Health News:Half of Teens Treated for Depression Will Relapse: Study 3Health News:Research explores lung cancer among pediatric cancer patients 2Health News:Pitt study finds NSAIDs cause stem cells to self-destruct, preventing colon cancer 2Health News:Scientists turn a new leaf to discover a compound in daffodils that targets brain cancer 2
(Date:3/27/2015)... HOLLYWOOD, Calif. , March 27, 2015 ... of life of myeloma patients while working toward prevention ... Higgins (D-NY) for introducing a federal resolution (H. ... of March 2015 as "National Multiple Myeloma Awareness Month." ... living with myeloma worldwide, and more than 110,000 new ...
(Date:3/27/2015)... N.J. , March 27, 2015  Johnson & Johnson ... Shareholders at 10 a.m. (Eastern Time) on Thursday, April 23, ... N.J. Investors and other interested parties ... visiting the Company,s website at www.jnj.com and clicking ... from the meeting will be made available a few hours ...
(Date:3/27/2015)... March 27, 2015 Concord Medical Services ... CCM ), a leading specialty hospital management ... of radiotherapy and diagnostic imaging centers in ... of a purchase agreement under which Concord Medical ... of the Company, agreed to acquire the Fortis ...
Breaking Medicine Technology:The International Myeloma Foundation (IMF) Secures the Introduction of a Federal Resolution Recognizing March 2015 as "National Multiple Myeloma Awareness Month" 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3
... 2007 /PRNewswire/ -- DNA Therapeutics,S.A. an emerging pharmaceutical ... elucidation of a new mechanism,of action and the ... molecule Dbait. It will be,presented at the forecoming ... abstract is now available online.,The presentation itself will ...
... Potent Synergy, Activity and Patient Tolerance Support ... Spain, April 12, 2007 /PRNewswire/ -- Intarcia,Therapeutics, ... final results from a Phase 2 study ... treatment-naive patients,with genotype 1 chronic hepatitis C. ...
Cached Medicine Technology:DNA Therapeutics Reports a Novel Mechanism of Action and a,Biomarker of its Lead Molecule Dbait That Open an Innovative,Pathway-Targeting in Molecular Cancer Therapy 2DNA Therapeutics Reports a Novel Mechanism of Action and a,Biomarker of its Lead Molecule Dbait That Open an Innovative,Pathway-Targeting in Molecular Cancer Therapy 3Intarcia Therapeutics Announces Final Results From a Phase 2 Study,of Injectable Omega Interferon plus Ribavirin for the Treatment of,Hepatitis C Genotype-1 2Intarcia Therapeutics Announces Final Results From a Phase 2 Study,of Injectable Omega Interferon plus Ribavirin for the Treatment of,Hepatitis C Genotype-1 3Intarcia Therapeutics Announces Final Results From a Phase 2 Study,of Injectable Omega Interferon plus Ribavirin for the Treatment of,Hepatitis C Genotype-1 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: