Navigation Links
Effective pain treatment for cancer patients?
Date:6/25/2009

Cancer patients often suffer from severe pain that cannot be effectively treated with conventional medication. Researchers at the Pharmacology Institute of the University of Heidelberg have found the possible reasons for this tumors release two signal substances that make nerve cells especially sensitive and enhance tumor growth. In animal tests, when the researchers blocked the effect of the signal substances on the nerve cells, the sensitivity of the nerve cells and tumor growth were reduced.

The results of the research of the international working group headed by Professor Dr. Rohini Kuner indicate a new approach for the development of effective pain medication for cancer patients. The work has now been published online in the prestigious journal Nature Medicine.

Tumor pain: new therapies are urgently needed

For patients, severe pain is one of the worst and most feared symptoms of cancer. The causes of the frequently extreme pain are still largely unknown. Cancer pain is frequently difficult to handle with conventional pain medication such as opioids. High dosages are required to achieve any effect at all as a result, the side effects are immense for the patients and tolerance may quickly ensue. "There is a great need for special pain medication for cancer patients," says pharmacologist Professor Dr. Rohini Kuner, who is especially interested in explaining the mechanisms of chronic pain.

Tumor signals make nerve cells extremely sensitive to pressure

In this research project, she and her colleagues examined tissue from mice to determine what signal substances were released by tumors. They discovered two molecules that were previously known only as growth factors for blood-forming stem cells. Contact with these molecules made nerve cells in the vicinity of the cancer tissue considerably more sensitive to pressure, as the researchers demonstrated by testing nerve activity with electrodes. "The findings are consistent with descriptions of cancer patients who say that merely touching the affected area is painful," explained Professor Dr. Kuner.

But not just touching, even tumor growth itself causes pain, for the expanding tissue also exerts pressure. The cancer cells apparently use the growth factors for their own growth and spread through the nerve pathways and blood vessels to the rest of the organism.

An injection against tumor pain?

The discovery made in Heidelberg opens up new prospects in the fight against cancer pain in the next step, the researchers injected proteins (antibodies) that block the contact sites for cancer signal substances on the nerve cells. Indeed, the sensitivity of nerve cells and tumor growth were reduced.

Further research must now show whether this use is also possible in human tissue. If so, it would be conceivable to inject these "protein blockers" directly into the tumor and thus reduce pain and side effects for the patient.


'/>"/>

Contact: Dr. Rohini Kuner
rohini.kuner@pharma.uni-heidelberg.de
49-622-154-8289
University Hospital Heidelberg
Source:Eurekalert  

Related medicine news :

1. New treatment effective in counteracting cocaine-induced symptoms
2. Use of certain lipid measures not more effective in predicting coronary heart disease
3. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
4. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
5. Stanford study highlights cost-effective method of lowering heart disease risks
6. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
7. Case Management Cost-Effective Way to Cut Heart Risks
8. ResMed Names Kieran Gallahue as Chief Executive Officer, Effective January 1, 2008.
9. Nasal Anthrax Vaccine Proves Effective in Animal Study
10. Family-based treatment more effective than supportive psychotherapy in treating bulimia
11. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Effective pain treatment for cancer patients?
(Date:5/23/2016)... , ... May 23, 2016 , ... NYDNRehab, a New ... program for athletes. This is the first time this type of technology, which was ... made available to the public in New York. , With over 10 million ...
(Date:5/23/2016)... Diego, CA (PRWEB) , ... May 23, 2016 , ... ... various regulatory subjects will host medical device summit on September 15 and 16, ... world’s leading experts and former FDA office bearers will be one of the largest ...
(Date:5/23/2016)... (PRWEB) , ... May 23, ... ... and security executive networking and relationship-marketing firm, announced today that nominations will ... Information Security Executive® (ISE®) Northeast Awards. , Awards include the Information Security ...
(Date:5/23/2016)... ... May 23, 2016 , ... ... education worldwide for people who are blind or visually impaired, announces the election ... retiring President Charles E. Young. Hadley’s Board of Trustees retained Morris & Berger, ...
(Date:5/23/2016)... ... 2016 , ... Octo Consulting Group, a leading provider of innovative information technology ... they have recently won two awards from AFCEA International. Octo was selected as ... Additionally, Octo VP of Civilian Affairs, Naina Leo, was named a winner of the ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... The global  reprocessed medical devices ... 2022, according to a new study by Grand View ... with the lack of centralized support for waste disposal ... demand for reprocessed medical devices market. Additionally, the long-term ... of the original device is the high impact rendering ...
(Date:5/20/2016)... 2016 ReportsnReports.com adds Global ... Devices of its online business intelligence library. This ... current state of the Titrator industry. The report ... definitions, classifications, Specifications, applications and industry chain structure. ... Raw Material Suppliers, Equipment Suppliers, Manufacturing Cost Structure, ...
(Date:5/20/2016)... India , May 20, 2016 ... growth driver is the increasing demand for affordable healthcare solutions ... been steadily on the rise. In countries like the US, ... decade. In the US, the consumer price index inflation rate ... healthcare inflation rate moved up to 3.62% during the same ...
Breaking Medicine Technology: