Navigation Links
Effective drugs for Parkinson's reduce symptoms of Rett syndrome in mice
Date:6/16/2014

IDIBELL researchers, led by the director of the Program for Epigenetics and Cancer Biology, ICREA researcher and Professor of Genetics at the University of Barcelona, Manel Esteller, have shown that a combination of effective drugs for Parkinson's disease in mice that are used as a model of human Rett syndrome reduces some of the symptoms associated with this disease. The results of the study are published in the journal Neurophsycopharmacology

Second leading cause of mental retardation in females

Rett syndrome is the second most common cause of mental retardation in women, after Down syndrome. It is a neurodevelopmental disease whose clinical picture begins to appear 6-18 months after birth and involves a loss of intellectual, social and motor skills, accompanied by autistic behaviors, such as repetitive movements of the hands.

The syndrome is usually due to the presence of a mutation in the MECP2 gene, an epigenetic gene which controls the activity of many other genes like a padlock. Today there is no effective treatment of the disease. Manel Esteller's group, in collaboration with the group of neurometabolic diseases IDIBELL led by Aurora Pujol, described this week in the journal Neuropsycopharmacology how drug treatment in mice used as models of Rett syndrome reduces some of the symptoms associated with the disease .

Altered production via Dopamine

"Six years ago, studying the brains of mice that faithfully present the same characteristics of human Rett syndrome, we found that there was an alteration in the way of production of dopamine, a neurotransmitter. Here, Rett syndrome bore some resemblance to Parkinson, which also presents defects in the same molecule.

There are effective drugs in Parkinson's so we decided to study whether they could also function in Rett syndrome, "says Manel Esteller. "We found that combined treatment with L-Dopa and Dopa decarboxylase inhibitor reduces typical manifestations of the disease and mobility defects, tremor and respiratory distress in these animals."

"This is not a panacea or a magic pill or" warns Esteller "but at least is a starting point to study whether it may also be useful in controlling the symptoms of Rett syndrome in humans."


'/>"/>
Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert  

Related medicine news :

1. Miriam Hospital study shows how to make statewide health campaigns more effective
2. Liver cancer vaccine effective in mice
3. Radiofreqeuncy ablation and complete endoscopic resection equally effective for dysplastic Barretts esophagus
4. Is Duloxetine more or less effective than Fluoxetine in children and teens with MDD?
5. Widely used drug no more effective than FDA approved medication in treating epileptic seizures
6. New agent may enhance effectiveness of radiotherapy
7. A form of immune therapy might be effective for multiple myeloma
8. Universal neuromuscular training an inexpensive, effective way to reduce
9. Study finds family-based exposure therapy effective treatment for young children with OCD
10. New study says probiotic use for infant colic is not effective in reducing symptoms
11. New human trial shows stem cells are effective for failing hearts
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Effective drugs for Parkinson's reduce symptoms of Rett syndrome in mice
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
Breaking Medicine Technology: