Navigation Links
Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients
Date:2/27/2008

A chronic autoimmune disease, rheumatoid arthritis (RA) is characterized by persistent inflammation of the synovial membrane and progressive joint destruction. Beyond loss of mobility, sufferers face a high risk of heart failure. An inflammatory cytokine known for contributing to the development of RA, tumor necrosis factor a (TNFa) has also been implicated in cardiovascular disorders. Inhibition of TNFa has opened promising new treatment options for RA patients. Anti-TNF drugs such as infliximab, etanercept, and adalimumab have been shown to not only diminish signs and symptoms of the disease, but also prevent joint damage. However, in cardiac trials, TNFa inhibitors have shown no more positive effects on heart failure risk -- and sometimes less -- than placebo.

Does TNFa inhibition prevent heart failure in RA patients -- or promote it? That's the critical question Dr. Joachim Listing and a team of specialists with the German Rheumatism Research Centre in Berlin set out to answer. Featured in the March 2008 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), their study indicates that anti-TNF therapy does a patients heart more good than harm, when it successfully reduces the inflammatory toll of RA.

To clearly assess the role of TNFa inhibitors in heart failure risk, the researchers analyzed a 3-year span of disease activity and cardiovascular incidents in 4,248 RA patients enrolled in an ongoing Germany-wide study of biologic therapy. At the time of enrollment, 2,757 of the subjects had started treatment with an anti-TNF drug -- infliximab, etanercept, or adalimumab -- and 1,491 had started a new disease-modifying antirheumatic drug (DMARD). Within the study period, several hundred of the patients were also treated with glucocorticoids, nonsteroidal anti-inflammatory drugs (NSAIDs), or COX-2 inhibitors. Over 78 percent of the p
'/>"/>

Contact: Amy Molnar
amolnar@wiley.com
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hormone replacement therapy appears to have no effect on risk and severity of rheumatoid arthritis
2. Colgate Announces 11% Dividend Increase Effective 2nd Quarter 2008
3. Cause of effectiveness discovered for a cirrhosis treatment useful in 40 percent of patients
4. Effective Healthy Eating and Physical Activity Initiatives Can Reduce Health Disparities
5. Prime Therapeutics Introduces Efficiency Program to Help Employers Understand How to Most Effectively Spend Pharmacy Dollars
6. UC study: New devices less effective in thwarting brain aneurysm recurrence
7. Guidelines for evaluation of psychological side-effects of brain injury
8. Researchers explore the antidepressant effects of ketamine
9. Warning: Expert at UH adds obesity to side effects of lead exposure
10. In Combination With FOLFOX4, the Effect of Erbitux and Avastin On Survival Rates Will Drive Prescription Decisions in the Treatment of Stage III Colon Cancer
11. Building an Effective Sales Force to Serve the U.S. Hospital Market
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new blog post explaining how ... , Smoking will always have a negative impact on ... method to find affordable coverage. Insurance brokerage websites specialize ... , Whole life insurance premiums will be fixed throughout ... is permanent, the initial rates are very important. ...
(Date:10/1/2014)... ST. LOUIS, MO (PRWEB) October 01, 2014 ... up for Castlewood Eating Disorder Treatment Center’s first ever charity ... provides grants for people with eating disorders who cannot afford ... Fox Run Golf Club in Eureka, Mo. , The ... time at noon. A reception and award dinner will begin ...
(Date:10/1/2014)... Diet Doc understands that many of their clients ... their dieting attempts could be easily sabotaged by the temptation ... treatments into their programs as a way to control ... effective weight loss results, it also allows patients to stick ... their weight for the future. , Earlier versions of the ...
(Date:10/1/2014)... the occasion of the Leishmaniasis East Africa Platform ... international leishmaniasis experts, results of a pharmacovigilance ... plan, carried out by MSF, DNDi, and national ... presented to key decision makers in order to ... the combination of Sodium Stibogluconate and Paromomycin (SSG&PM) ...
(Date:10/1/2014)... Today marks the final day prosthodontist Dr. Saj ... and Woodland Hills, Calif., is in the southern India ... “Speaking to this group of specialists allows more people ... help and care they deserve,” Dr. Jivraj said. , ... providing cosmetic dentistry, correcting bite issues, placing implants, and ...
Breaking Medicine News(10 mins):Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 3Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 4Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 5
... 27 New Jersey Senate Majority Leader Stephen M. Sweeney ... join Labor Leaders Charles Wowkanech , President of the New ... Counties Central Labor Council and Henry Nichola s, President of ... rallies in Deptford and Hammonton, N. J., in support of ...
... Governor Edward G. Rendell today announced that ... Senate confirmation:State Board of Medicine , James W. ... of Nursing Home Administrators , Mary Ann Hewston, ... creating a first-rate public education system, protecting our ...
... Healthier, More Productive PracticeNEWBERG, Ore., Feb. 27 ... is well-positioned to fit small spaces and conservative ... a mid-level platform choice that,s lower in cost ... performance, service, and support that distinguish A-dec products. ...
... can be used on all women with diagnosis, study ... new genetic test that analyzes a set of 50 ... lead to quicker, more immediate treatment for patients, according ... "Unlike a widely used genomic test that applies only ...
... Refute USA Today ReportHARRISBURG, Pa., Feb. 27 The ... unsafe levels of air pollutants or metals after extensively ... schools.Environmental Protection acting Secretary John Hanger said that the ... USA Today in December 2008 that relied only ...
... Feb. 27 Smith & Nephew, Inc.,(NYSE: ... announced the,introduction of a metal liner option for its ... in hip replacement and resurfacing,procedures. , ... Food and Drug Administration,for use with the BIRMINGHAM HIP(TM) ...
Cached Medicine News:Health News:Politicians and Labor Leaders Set to Lead Rallies Saturday (February 28) for Striking Innova Nurses 2Health News:New A-dec 300(TM) Offers Dentists an Innovative Equipment Solution 2Health News:New Test May Mean Faster Breast Cancer Treatment 2Health News:PA DEP Finds Air Quality Around Schools to be Safe 2Health News:PA DEP Finds Air Quality Around Schools to be Safe 3Health News:Smith & Nephew Introduces Metal Liner Option for the Modular R3(TM) Acetabular Cup System 2Health News:Smith & Nephew Introduces Metal Liner Option for the Modular R3(TM) Acetabular Cup System 3
(Date:10/1/2014)...   Royal Philips (NYSE: ... and eCareCompanion telehealth applications have received 510(k) clearance ... A part of Philips Hospital to Home,s ... are focused on patient care within the home ... available through the cloud-based digital health platform, which ...
(Date:10/1/2014)... LAUSANNE , Suisse, October 1, 2014 /PRNewswire/ ... génomique clinique et dans le domaine de l,analyse ... a lancé aujourd,hui une solution de diagnostic in ... d,exécuter une analyse complète de la mucoviscidose dans ... d,identifier et de caractériser tous les types de ...
(Date:9/30/2014)... 30, 2014  Wrightington, Wigan ... MDRX ) are delighted to announce WWL,s ... new health information system. The system will be implemented ... the way WWL delivers healthcare in the future. ... record of on-time and on-budget system implementations as well ...
Breaking Medicine Technology:Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 3Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 4Sophia Genetics lance une analyse complète du gène CFTR dans un essai clinique SGN 2Sophia Genetics lance une analyse complète du gène CFTR dans un essai clinique SGN 3Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 2Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 3Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 4
... , July 28 HemaQuest Pharmaceuticals, a ... sickle cell disease, beta thalassemia and EBV-related cancers, announced ... to its Series B financing by new investor, Latterell ... financing to $16M . The financing is intended ...
... July 27 /PRNewswire-Asia/ -- WuXi PharmaTech (Cayman) Inc. ... Proxy Advisory Services,("ISS"), a leading independent proxy voting and corporate ... River,s proposed,acquisition of WuXi. Two other proxy advisory services, Glass ... the,transaction. , , ...
Cached Medicine Technology:HemaQuest Pharmaceuticals Raises Additional $4M to Bring Total to $16M in Series B Financing 2ISS Recommends That WuXi Shareholders Vote for Proposed Combination With Charles River 2ISS Recommends That WuXi Shareholders Vote for Proposed Combination With Charles River 3ISS Recommends That WuXi Shareholders Vote for Proposed Combination With Charles River 4ISS Recommends That WuXi Shareholders Vote for Proposed Combination With Charles River 5
... secreted by the kidney, plays a ... The renin-angiotensin system regulates blood pressure, ... by the kidney. Renin is secreted ... decreased intravascular volume and decreased plasma ...
... polypeptide hormones which belong to the ... TGF- superfamily is a large group ... many aspects of development, reproductive function ... incude TGF-s, bone morphogenetic proteins, growth ...
... hormones which belong to the transforming ... superfamily is a large group of ... aspects of development, reproductive function and ... TGF-s, bone morphogenetic proteins, growth differentiation ...
... also known as bone Gla protein, is ... is a major component of the noncollagenous ... osteoblasts in bone, with a small amount ... chondrocytes [1]. During bone formation, newly synthesized ...
Medicine Products: