Navigation Links
Effect of reducing blood pressure with medications immediately following ischemic stroke
Date:11/17/2013

Chicago Jiang He, M.D., Ph.D., of the Tulane University School of Public Health and Tropical Medicine, New Orleans, and colleagues examined whether moderate lowering of blood pressure within the first 48 hours after the onset of an acute ischemic stroke would reduce death and major disability at 14 days or hospital discharge.

"Stroke is the second leading cause of death and the leading cause of serious, long-term disability worldwide. Clinical trials have documented that lowering blood pressure reduces the risk of stroke in hypertensive and normotensive patients with a history of stroke or transient ischemic attack. Although the benefit of lowering blood pressure for primary and secondary prevention of stroke has been established, the effect of immediate antihypertensive treatment in patients with acute ischemic stroke and elevated blood pressure is uncertain," according to background information in the article.

The China Antihypertensive Trial in Acute Ischemic Stroke, a randomized controlled trial, was conducted among 4,071 patients with ischemic stroke within 48 hours of symptom onset and elevated systolic blood pressure. Patients were recruited from 26 hospitals across China between August 2009 and May 2013. Patients (n = 2,038) were assigned to receive antihypertensive treatment (aimed at lowering systolic blood pressure by 10 percent to 25 percent within the first 24 hours after randomization, achieving blood pressure less than 140/90 mm Hg within 7 days, and maintaining this level during hospitalization) or to discontinue all antihypertensive medications (control) during hospitalization (n = 2,033).

Average systolic blood pressure was reduced from 166.7 mm Hg to 144.7 mm Hg (-12.7 percent) within 24 hours in the antihypertensive treatment group and from 165.6 mm Hg to 152.9 mm Hg (-7.2 percent) in the control group within 24 hours after randomization. Average systolic blood pressure was 137.3 mm Hg in the antihypertensive treatment group and 146.5 mm Hg in the control group at day 7 after randomization. The primary outcome (a combination of death and major disability at 14 days or hospital discharge) did not differ between treatment groups (683 events [antihypertensive treatment] vs. 681 events [control]) at 14 days or hospital discharge. The secondary composite outcome of death and major disability at 3-month posttreatment follow-up did not differ between treatment groups.

These findings suggest that the decision to lower blood pressure with antihypertensive treatment in patients with acute ischemic stroke does not improve or worsen outcome and therefore should be based on individual clinical judgment, the authors write.


'/>"/>

Contact: Arthur Nead
anead@tulane.edu
504-247-1443
The JAMA Network Journals
Source:Eurekalert

Related medicine news :

1. Study examines effectiveness, safety of transcatheter aortic valve replacement in US
2. Discover An Effective Skin Care Business Plan With The “Skin Care Tycoon” Course – Vinamy
3. Discover A Safe And Effective Diabetic Peripheral Neuropathy Treatment With The “Peripheral Neuropathy Solution” Program – Vinamy
4. Discover an Effective Eating Plan to Gain Muscle Mass Fast With the “How Much Protein” Program – Vkoolelite
5. The Natural Cure for HPV Review Discloses Andrea Segovia's New Effective HPV Remedy
6. Exercise training is effective as prehabilitation before surgery in an elderly population
7. Wartrol: the Natural and Effective Genital Warts Relief Solution Now Available in the Market with 1 Extra Bottle Offer
8. 50% Off Exciting One-Day Sale on Face Whisperer® Night Cream from Sublime Beauty®; Rare Sale for the Effective Anti-Aging Serum
9. Asbestos Found in Winnebago County Jail, Florida Asbestos Testing Company AGC Environmental Offers Tip How to Avoid the Mineral Fiber's Fatal Health Effects
10. Cutting edge research into drug side effects could save NHS money and make more drugs safely available
11. Dr. Oz Show Discusses Long-term Side Effects of LASIK
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2018)... ... December 05, 2018 , ... Advanced Clinical, ... services, announced its new office location in Paris, France during the Partnerships in ... trial operations in Europe and additional in-country personnel. , “The new office broadens ...
(Date:12/5/2018)... ... December 05, 2018 , ... What is Rosacea: ... are poorly understood. It manifests on the face, especially the cheeks, chin, nose ... cause enormous social and psychological problems. , Although it is considered incurable, the ...
(Date:12/5/2018)... ... , ... Dr. Jessica Allen of Northern Colorado Periodontics is pleased to offer ... in the Fort Collins area. Dr. Allen joins an elite class of periodontists ... lost to gum disease. , "Gum disease is a problem that many people have, ...
(Date:12/5/2018)... ... December 05, 2018 , ... You can now experience two ... LTRMN , is a powerhouse in the cannabis industry with several brands including ... is an industry leading, award winning , botanical terpene company that focuses ...
(Date:12/5/2018)... ... December 05, 2018 , ... To change the world, we ... at the DoubleTree Hilton Hotel in Newark, California. Led by world-renowned nursing theorist ... Watson Caring Science Institute, participants and esteemed guests discussed the impact of caring ...
Breaking Medicine News(10 mins):
(Date:12/5/2018)... ... 05, 2018 , ... HealthChannels, the industry leader in medical ... Tony Andrulonis, MBA to lead company-wide operational performance initiatives. , As COO, ... support staff. Prior to joining HealthChannels, Andrulonis held leadership roles throughout his nearly ...
(Date:12/5/2018)... ... 2018 , ... Florida Hospital West Florida Division has once ... prestigious Leapfrog Group, a national nonprofit health care ratings organization, announced the Top ... Sebring, Florida Hospital Wesley Chapel and Florida Hospital Zephyrhills all received the Top ...
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... ... in Cardiff, Wales. The BFE meeting is an interdisciplinary biofeedback conference to nurture ... medicine, physical therapy, education and other disciplines come together to share and learn. ...
Breaking Medicine Technology: