Navigation Links
Effect of medication is affected by copies of genetic information
Date:4/10/2013

The results may help to explain why certain medications have strong side effects on sperm and eggs, and why certain organisms remain unaffected by environmental changes. This is shown by studies that researchers from the University of Gothenburg, together with researchers from Norway and France, are now publishing in the journal PLOS Genetics.

All cells in our bodies contain copies of the genetic information. However, different cells contain different numbers of the complete genetic information. Normal human cells usually contain two copies of the genetic information, and thus two copies of every gene. Eggs and sperm, however, only contain one set of genes.

"At the same time, the cells of many plants and amphibians contain many more copies of genetic information, and the number of copies can also vary during an organism's development and between different stages of life," explains Jonas Warringer, a researcher at the University of Gothenburg's Department of Chemistry and Molecular Biology.

Research has often overlooked this variation in genetic information. However, Jonas Warringer and his colleagues have now used ordinary baker's yeast to show that the number of copies of genetic information has a decisive effect on the properties of cells.

Jonas and his colleagues collected yeast samples from around the world and created two variants of each yeast culture one with two copies of the genetic information, and the other with just one copy. The researchers then examined the properties of these yeast cells, such as their tolerance to cancer medication and antibiotics. The study, which is reported on in the journal PLOS One, shows that the number of copies of genetic information has a decisive effect on the properties of cells.

"The cells with two copies of genetic information showed greater tolerance to some substances," continues Jonas, "while in other cases those with only one copy had an advantage. Surprisingly enough, these effects were even maintained in species separated by several billions of generations of evolution, suggesting that they are actually of great importance in nature."

The researchers' discovery may be of considerable significance in terms of knowledge about what lies behind differences between organisms in nature.

"It may also help to explain why certain medications have particularly strong side effects on sperm and eggs whereas others do not, and why certain organisms are affected by some environmental changes while others are unaffected," he concludes.


'/>"/>

Contact: Jonas Warringer
jonas.warringer@cmb.gu.se
46-073-022-6322
University of Gothenburg
Source:Eurekalert

Related medicine news :

1. Young girls more likely to report side effects after HPV vaccine
2. Preteens More Likely to Report HPV Vaccine Side Effects
3. In children born with severe heart defect, surgical management has little effect on neuro outcomes
4. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
5. Breast cancer patients suffer treatment-related side effects long after completing care
6. Breast Cancer Treatment Side Effects May Last for Years
7. Baldness Drug May Cause Sexual Side Effects: FDA
8. Study examines adverse effects among different radiation therapies for prostate cancer
9. HIV Prevention Pill Cost-Effective for High-Risk Men: Study
10. Pig stomach mucins are effective as anti-viral agents for consumer products
11. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2017)... ... April 22, 2017 , ... ... as Vice President of Sales and Business Development at OAKWORKS, Inc. Mr. ... engagements, business development, and strategic planning for the company. Recognized industry-wide as ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... An April ... of a pair of ancient teeth, which reveal a great deal about prehistoric ice-age ... a sharp stone may have been used to remove decayed dental matter, and that ...
(Date:4/21/2017)... ... April 21, 2017 , ... The staff at Palm Beach Face is proud to ... in the 2017 London Marathon. Set to take place on April 23rd, the London Marathon ... Dr. Schwartz will run as part of team EMPOWER, raising money for the international charity, ...
(Date:4/21/2017)... , ... April 21, 2017 , ... Chicago plastic surgeon, ... removal of osteoma. An osteoma is a benign bony lump located on the forehead ... and can cause difficulties with sight and pain. Dr. Shah has discovered an approach ...
(Date:4/21/2017)... Wis. (PRWEB) , ... April 21, 2017 , ... ... today announced that its B-595 and B-7569 vinyl label materials ... identification and warning labels are tested to remain intact and legible, for use on ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... ZappRx, Inc ., a digital health company focused on modernizing ... closed $25 million in Series B funding led by Qiming ... Seattle that is part of a broader ... round included participation from SR One , who led ... (formerly Google Ventures). As part of the financing, Mark ...
(Date:4/20/2017)... , April 20, 2017 Research and ... Market Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, ... report to their offering. ... The global pharmacogenomics market was valued at US$ 7,167.6 Mn ... by 2024, expanding at a CAGR of 5.6% from 2016 ...
(Date:4/20/2017)... , April 20, 2017 NeuroVive Pharmaceutical ... today announced positive preclinical results demonstrating anti-fibrotic ... for non-alcoholic steatohepatitis (NASH), in an additional ... NV556 has previously shown similar anti-fibrotic ... Today, NeuroVive,s scientists present novel data demonstrating ...
Breaking Medicine Technology: