Navigation Links
Effect of adenotonsillectomy in children with sleep-disordered breathing
Date:12/19/2011

Alexandria, VA -- Children may have a better quality of life (QOL) and diminished cardiovascular disease risk from the decreased endothelin 1 (ET-1) levels after adenotonsillectomy, according to new research published in the December 2011 issue of Otolaryngology Head and Neck Surgery.

SDB is an increasingly common indication for tonsillectomy and adenoidectomy due to obstructive sleep apnea syndrome (OSAS). Cardiovascular (CV) disease frequently has been reported in patients with moderate to severe OSAS, related abnormalities include: systematic hypertension, pulmonary hypertension with corpulmonale, left ventricular (LV) hypertrophy or dysfunction, cardiac arrhythmias, atherosclerosis, and coronary artery disease.

The study sample included an obstructive sleep apnea survey and a detailed personal and family history. All subjects underwent a complete otolaryngologic examination, otoscopy, and anterior rhinoscopy. Thirty-seven children with a diagnosis of upper airway obstruction caused by adenotonsillar hypertrophy (ATH) were included in the study. Twenty female and 17 male patients, between 3 and 13 years old participated in the study.

Surgical procedures included: 20 tonsillectomies and adenoidectomies (54%), 15 adenoidectomies only (40.6%), and 2 tonsillectomies only (5.4%). Study results show when comparing moderate and severe cases to mild cases according to Brouilette scores, ET-1 levels were significantly higher in moderate and severe cases (P <.01). There was a significant correlation between ET-1 and the OSA-18 survey scale (r =0.442; P =.001).

The objective of the study was to evaluate the influence of adenotonsillectomy on the plasma concentration of ET-1 levels and C-reactive protein (CRP) in children with sleep-disordered breathing (SDB). The primary goal of this research study was to investigate the effect of ATH and adenotonsillectomy on the possible pathogenic mechanisms (endothelial dysfunction and inflammation) that lead to cardiovascular complications.

Based on the study findings, the authors indicate: "that children with SDB who undergo adenotonsillectomy may have a better QOL, and the positive influence of adenotonsillectomy on CV function might be mediated by the decrease in ET-1 levels." The study's authors acknowledge that more research is needed, noting: "Further studies with longer follow-up and a larger population sample are warranted to demonstrate the association between SDB due to ATH and ET-1 levels and to confirm the influence of adenotonsillectomy on ET-1 and CRP levels to prevent cardiovascular disease in children."


'/>"/>
Contact: Mary Stewart
mstewart@entnet.org
703-535-3762
American Academy of Otolaryngology - Head and Neck Surgery
Source:Eurekalert

Related medicine news :

1. Heart drug may be effective for managing certain cancers: Queens University study
2. Side Effects Cause Many Older Women to Drop Breast Cancer Drugs
3. Behavior of people faced with health-care choices is not influenced by framing effect, study finds
4. Study finds side effects, complications, mastectomy more likely after partial breast irradiation
5. Reusing pacemakers from deceased patients is safe and effective, study finds
6. If a fat tax is coming, heres how to make it efficient, effective: ISU economists
7. Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
8. Researchers validate preclinical effectiveness of TB drug target
9. Tenofovir gel dropped from HIV prevention trial in women because it was not effective
10. Similar effects of beer and wine on the risk of cardiovascular disease
11. Tamoxifen causes significant side effects in male breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
Breaking Medicine Technology: