Navigation Links
Edoxaban effective in preventing stroke, reducing bleeding and cardiovascular death in patients with atrial fibrillation
Date:11/19/2013

with atrial fibrillation (irregular heart rate) who were at moderate-to-high risk for stroke. The trial was conducted at 1,393 centers in 46 countries. Participants were enrolled from November 2008 to November 2010.

Patients had an equal chance to receive warfarin, high-dose edoxaban (60 milligrams/day), or low-dose edoxaban (30 milligrams/day), although knowledge of which treatment they were assigned was not revealed until after the end of the study.

About one-quarter of the patients had the dose of edoxaban lowered at the start of the trial based on their individual profile to ensure the desired blood level of the drug. To ensure patients treated with warfarin had the proper degree of blood-thinning, blood tests were performed at least monthly in each group, although such testing is not necessary with edoxaban.

The primary goals of the study were to assess the combined outcome of stroke or systemic embolism (primary efficacy outcome), as well as bleeding.

During the treatment period, the rate of stroke or systemic embolism was 1.50 percent per year for participants on warfarin, and 1.18 percent per year for those on high-dose edoxaban. This represents a 21 percent reduction in the risk of stroke or systemic embolism with high-dose edoxaban compared to warfarin.

Moreover, annualized rates of major bleeding were 3.43 percent with warfarin and 2.75 percent with high-dose edoxaban, representing a 20 percent reduction in bleeding. There were also fewer cardiovascular deaths with edoxaban compared to warfarin: high-dose edoxaban 2.74 percent per year compared to warfarin 3.17 percent per year.

The favorable results with edoxaban were achieved despite excellent management with warfarin in this study (blood tests were in range more than two-thirds of the time, a higher rate than that seen in other similar studies).

Future research with edoxaban will investigate if patients with other conditions treated
'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-525-6383
Brigham and Women's Hospital
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. HIV Prevention Pill Cost-Effective for High-Risk Men: Study
2. Pig stomach mucins are effective as anti-viral agents for consumer products
3. Lower-Dose Radioiodine Effective Against Thyroid Cancer
4. Aspirin as Effective as Warfarin for Heart Failure: Study
5. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
6. Breast cancer effectively treated with chemical found in celery, parsley by MU researchers
7. Researchers make promising discovery in pursuit of effective lymphoma treatments
8. Breast MRI helps predict chemotherapys effectiveness
9. Kitchen exhaust fans vary in effectiveness in reducing indoor air pollution
10. New drug found effective against rare form of basal cell skin cancer
11. New Drug Effective for Rare Genetic Skin Cancer: Studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Edoxaban effective in preventing stroke, reducing bleeding and cardiovascular death in patients with atrial fibrillation
(Date:8/21/2014)... PA (PRWEB) August 21, 2014 The ... Crossing Historic Park in Washington Crossing, Pennsylvania on Thursday, ... the park. “We have been looking for different ways ... said Matt Kiernan, Partner with Pharmica Consulting. “When we ... part of U.S. history, we jumped at the opportunity.” ...
(Date:8/21/2014)... She was 12 years old when the unthinkable happened – ... correct her frequent headaches failed. , In her new ... her journey of overcoming devastating obstacles involving dual disability, greed ... justice for years. , “My faith in God helped ... light,” Strom-Stewart said. “But it took me more than a ...
(Date:8/21/2014)... 21, 2014 The rising numbers of teen ... Beach, FL. For many years, countless lives have been lost ... the community a new helpline was established to provide a ... who are seeking to overcome their youth substance abuse ... Beach helpline at (561) 257-4053, parents and their teens can ...
(Date:8/21/2014)... Michael E. Steuer , local doctor in Memphis, TN, ... City with recent philanthropy at local synagogue. “The state of ... says friend and Rabbi David Julian of Or Chadash in ... in-house for the needy and teaching Hebrew to students, Steuer ... synagogue. And to remain close with the development of Israel, ...
(Date:8/21/2014)... SC (PRWEB) August 21, 2014 ... of seven start-ups selected to participate in the ... provides entrepreneur mentorship, curriculum sessions and valuable resources.he ... businesses in the region. Each start-up selected for ... support in order to help businesses grow quickly, ...
Breaking Medicine News(10 mins):Health News:Pharmica Spends the Day Helping to Preserve Washington Crossing Historic Park 2Health News:The Dramatic, Uplifting Story from a Brain Injured Woman 2Health News:Troubled Teens in Boynton Beach, FL Turn to Helpline for Valuable Assistance 2
... possessing gun in assault situation 4.5 times more likely to be ... In a first-of-its-kind study, epidemiologists at the University of ... not protect those who possessed them from being shot in an ... 4.5 times more likely to be shot in an assault than ...
... ... today that Wayne Cockburn, President and CEO will present an overview of Muscle ... pain, neurology, medical device , ... Huntington Beach, CA (PRWEB) September 30, 2009 -- iTech Medical, Inc. (OTCBB: ...
... ... Publishing releases CNS Complications in the Immunocompromised Patient, an ABR-approved online radiology self-assessment ... ... 2009 -- Oakstone Medical Publishing announces the launch of the ABR-approved radiology online ...
... , WASHINGTON, Sept. 29 The American Federation of Government Employees ... Management that premiums under FEHBP would be rising by an average ... average is the fact that for 60% of the enrollees in ... premiums will be going up by 15% for self coverage and ...
... Cadence Pharmaceuticals, Inc. (Nasdaq: CADX ), a biopharmaceutical ... candidates principally for use in the hospital setting, announced ... will present the company,s corporate overview on Tuesday, October ... during the JMP Securities Healthcare Focus Conference at the ...
... and post-menopausal women who self-rated themselves as being sexually ... scores for "positive well-being" and "vitality," compared with sexually ... active more than twice a month. The study, ... , also uncovered a positive association between age and ...
Cached Medicine News:Health News:Penn Study Asks, Protection or Peril? Gun Possession of Questionable Value in an Assault 2Health News:Penn Study Asks, Protection or Peril? Gun Possession of Questionable Value in an Assault 3Health News:iTech Medical to Present at BioContact Qubec 2009 2Health News:iTech Medical to Present at BioContact Qubec 2009 3Health News:iTech Medical to Present at BioContact Qubec 2009 4Health News:iTech Medical to Present at BioContact Qubec 2009 5Health News:Oakstone Medical Publishing Introduces an Online ABR Qualified Self-Assessment Module for Radiologists Designed to Satisfy MOC Requirements 2Health News:Sexually satisfied women have better general well-being and more vitality 2Health News:Sexually satisfied women have better general well-being and more vitality 3
(Date:8/20/2014)... PLAINFIELD, N.J. , Aug. 20, 2014 PTC Therapeutics, ... will participate at two upcoming investor conferences: - ... Seasons Hotel in Boston on Wednesday, ... Biotech Conference at The Mandarin Oriental Boston on Thursday, September ... present a company update at the Bank of America Merrill ...
(Date:8/20/2014)... YORK , Aug. 20, 2014 ... is available in its catalogue: The ... IVD Industry http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html ... Act" (H.R. 3590) is complex legislation that affects ... of its provisions are beginning to take effect ...
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces that ... in its catalogue: Personal Accident ... and Opportunities to 2017 ... The report provides in depth market analysis, ... accident and health insurance segment, including: • ...
Breaking Medicine Technology:PTC Therapeutics to Participate at Upcoming Investor Conferences 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 2Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 3Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 4Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 5Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 7Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 8Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 9Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 10Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 11Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 12Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 13Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 14Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 15Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 16Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 17Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 18Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 19Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 20Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 21Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 22Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 23
... REDWOOD CITY, Calif., March 19, 2012 Ingenuity Systems, ... life science researchers, today announced that the Weill Cornell ... iReport for use in its sequencing core facility.  Variant ... the output of whole genome and exome sequencing experiments ...
... 19, 2012  Johnson & Johnson (NYSE: JNJ) will provide ... parties on Monday, March 26th at approximately 10:30 ... College of Cardiology (ACC) Annual Scientific Sessions in ... of the EINSTEIN-PE study in treating patients with ...
Cached Medicine Technology:Weill Cornell Medical College Selects Ingenuity® Variant Analysis™ and Ingenuity® iReport™ for Sequencing Core Facility 2
Adjustable Velcro© closures at crown and behind the neck distinguish this immediate post-op face and chin garment for maximum support and compression....
A CDI original design with seams on the outside, away from the skin, adjustable fit and removable/adjustable back strap, provides patient comfort and needed compression....
Ideal for autoplasty and liposuction of chin and cheeks...
Applies pressure on scalp to stretch it before surgery...
Medicine Products: