"Using natural products as building blocks provides a new direction for an old technology," said Jeremiah J. Gassensmith, a postdoctoral fellow in Stoddart's lab and an author of the paper.
"The metal-organic framework technology has been around since 1999 and relies on chemicals that come from crude oil," explained Ross S. Forgan, also a postdoctoral fellow in Stoddart's lab and co-first author of the paper. "Our main constituent is a starch molecule that is a leftover from corn production."
For their edible MOFs, the researchers use not ordinary table sugar but gamma-cyclodextrin, an eight-membered sugar ring produced from biorenewable cornstarch. The salts can be potassium chloride, a common salt substitute, or potassium benzoate, a commercial food preservative, and the alcohol is the grain spirit Everclear.
With these ingredients in hand, the researchers actually had set out to make new molecular architectures based on gamma-cyclodextrin. Their work produced crystals. Upon examining the crystals' structures using X-rays, the researchers were surprised to discover they had created metal-organic frameworks -- not an easy feat using natural products.
"Symmetry is very important in metal-organic frameworks," Stoddart said. "The problem is that natural building blocks are generally not symmetrical, which seems to prevent them from crystallizing as highly ordered, porous frameworks."
It turns out gamma-cyclodextrin solves the problem: it comprises eight asymmetrical glucose residues arranged in a ring, which is itself symmetrical. The gamma-cyclodextrin and potassium salt are dissolved in water and then crystallized by vapor diffusion with alcohol.
The resulting arrangement -- crystals consisting of cubes made from six gamma-cyclodextrin molecules linked in three-dimensions by potassium ions -- was previously unknown. The research team believes this strategy of
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