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Econiche(TM) Vaccine Shows 92% Reduction in Colonization of E. coli O157 in Vaccinated Cattle
Date:3/13/2009

vaccinated cattle (odds ratio (OR)=0.07, p=0.0008). This is the second published study demonstrating more than 90% effectiveness of the Bioniche vaccine against colonization.

The researchers concluded that the two-dose vaccine regimen effectively reduced the probability for E. coli O157:H7 colonization of the TRM of commercially fed cattle at harvest. "As evidenced in this study, the number of days elapsing between arrival processing and reprocessing can be quite variable in typical feedlot systems," said Dr. David Smith, Extension Dairy/Beef Veterinarian, Veterinary and Biomedical Sciences, University of Nebraska-Lincoln. "However, we found no evidence that this affected vaccine efficacy. Therefore, feedlot managers may have some flexibility in scheduling re-vaccination without risking loss of efficacy. It is important that pre-harvest intervention strategies remain effective up to the time of harvest. Within the range of observations in this study, the protective effect of vaccine did not change as the number of days between reprocessing and harvest increased." This is consistent with the results from longitudinal vaccine clinical trials of the Company's vaccine published in 2004, 2007 and 2008.

The Company's Econiche(TM) vaccine is the world's first vaccine developed to reduce the shedding by cattle of Escherichia coli (E. coli) O157:H7. Econiche received full licensing approval from the Canadian Food Inspection Agency (CFIA) in October, 2008 and is available for unrestricted use by Canadian cattle producers and their veterinarians.

The USDA cleared the path for a conditional license for the vaccine in February, 2008, and the Company in the process of completing the required manufacturing steps in the U.S. at this time.

Econiche is a Canadian discovery developed by Bioniche Life Sciences Inc. The vaccine has the potential to significantly reduce the amount of E. coli O157 shed into the environment by beef and dairy cattl
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SOURCE Bioniche Life Sciences Inc.
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