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Econiche(TM) Vaccine Shows 92% Reduction in Colonization of E. coli O157 in Vaccinated Cattle
Date:3/13/2009

- study conducted with 21 pens of cattle in commercial feedlots -

BELLEVILLE, ON, March 13 /PRNewswire-FirstCall/ - Bioniche Life Sciences Inc. (TSX: BNC), a research-based, technology-driven Canadian biopharmaceutical company, today announced that the results of a large-scale commercial beef feedlot study with the Company's E. coli O157 vaccine - Econiche(TM) - have been published in this month's issue of Foodborne Pathogens and Disease (Vol. 6, Number 2, 2009), a peer-reviewed scientific journal.

The article, entitled, "A Two-Dose Regimen of a Vaccine Against Type III Secreted Proteins Reduced Escherichia coli O157:H7 Colonization of the Terminal Rectum in Beef Cattle in Commercial Feedlots", was co-authored by David R. Smith, Rodney A. Moxley, Robert E. Peterson, Terry J. Klopfenstein, Galen E. Erickson, Gustavo Bretschneider, Emil M. Berberov, and Sharon Clowser.

The article summarized a large-scale clinical vaccine trial of commercially fed cattle that tested the efficacy of a two-dose regimen of the Econiche vaccine against type III secreted proteins of enterohemorrhagic Escherichia coli O157:H7 on the probability to detect the same organism from terminal rectal mucosa (TRM) as a measure of gut colonization. The TRM is the most significant point of colonization by E. coli O157 in cattle. Vaccine was administered to all cattle within treated pens at arrival processing and at re-implant processing. At harvest, TRM was collected from a sample of cattle from within vaccinated and non-vaccinated pens. Seven hundred eighteen cattle were tested from within 21 pens of cattle (11 vaccinated and 10 not vaccinated) representing 3,683 cattle. E. coli O157:H7 was cultured from 68 of 718 (9.5%) TRM samples. Eleven of 382 (2.9%) vaccinated cattle and 57 of 336 (17.0%) non-vaccinated cattle were TRM culture positive. From the multilevel logistic model, vaccinated cattle were 92% less likely to be colonized with E. coli O157:H7 than non-
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SOURCE Bioniche Life Sciences Inc.
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