Navigation Links
Ebola's secret weapon revealed
Date:5/2/2013

Researchers have discovered the mechanism behind one of the Ebola virus' most dangerous attributes: its ability to disarm the adaptive immune system.

University of Texas Medical Branch at Galveston scientists determined that Ebola short-circuits the immune system using proteins that work together to shut down cellular signaling related to interferon. Disruption of this activity, the researchers found, allows Ebola to prevent the full development of dendritic cells that would otherwise trigger an immune response to the virus.

"Dendritic cells typically undergo a process called 'maturation' when they're infected by a virus they change shape and present antigens on their surface that tell T-cells to attack that particular virus, thus generating an adaptive immune response," said UTMB professor Alexander Bukreyev, senior author of a paper on the discovery now online in the Journal of Virology. "But Ebola prevents dendritic-cell maturation and produces a severe infection without an effective adaptive immune response. We found that its ability to do this depends on several specific regions of two different proteins."

Bukreyev's research group made the discovery after a series of procedures that started with a clone of the Ebola Zaire virus strain. Working under maximum-containment conditions in a biosafety level 4 facility in UTMB's Galveston National Laboratory, the team introduced mutations into the virus' genetic code at four locations thought to generate proteins that affected immune response.

They then infected human dendritic cells with each of the resulting new strains and compared the results with those produced by unmutated Ebola Zaire. Each of the four new viruses, they found, was unable to suppress dendritic-cell maturation.

"We saw two very interesting things," Bukreyev said. "First, that these mutations restore maturation of dendritic cells very effectively, and second, that a mutation in even one of these genetic domains makes the virus unable to suppress maturation. That means that the virus needs multiple combined effects in order to undermine the immune system in this way."

Ebola's ability to evade the human immune response is one of the factors that accounts for its high mortality rate up to 90 percent in humans and the notoriety that it gained after its first appearance in Zaire in 1976, in an outbreak that killed 280 people. Zaire now the Democratic Republic of the Congo is the home country of Ndongala Lubaki, lead author on the paper and a postdoctoral fellow at UTMB.


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Dotcomsecrets is Offering New Opportunities to People Who Want to Become Expert in Localized Internet Marketing
2. DotComSecrets Invites Professionals to Learn Great Tips On How to Make a Handsome Income By Working As Local Internet Marketing Consultants
3. 13 Free Weight Loss Secrets Program Kicks-Off
4. DotComSecrets Offers Free Webinar to Make Individuals Skilled in Earning Thousands of Dollars by Becoming DCS’s Local Consultant
5. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
6. DotComSecrets Is Seeking Local DCS Consultants Through Free Webinars in Coming Days
7. Secrets of lung cancer drug resistance revealed at UCSF
8. Could the Naked Mole Rat Hold Secrets to Longevity?
9. UMass Amherst researchers unravel secrets of parasites replication
10. Unmasking the deadly secrets of pancreatic cancer
11. Secret of Anesthesia Revealed, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... 2017 , ... Patients with missing teeth now have the ... from Dr. Alejandro Kovacs. Dr. Kovacs is a board-certified periodontist and prosthodontist who ... dental implants in Longview, TX. , During traditional dental implant ...
(Date:7/27/2017)... ... 27, 2017 , ... TransPanel Volume 4 is a collection of animating panel ... exclusive features transitions that contain between 2 and 6 animated panels. Change the direction ... menus. TransPanel Volume 4 makes editing easy in Final Cut Pro X. , TransPanel ...
(Date:7/27/2017)... Clara, CA (PRWEB) , ... July 27, 2017 ... ... announces the addition of a secure cloud-based polysomnography (PSG) distributed scoring solution to ... support accelerated diagnostics and sleep care management. The speed and functionality of scoring ...
(Date:7/27/2017)... ... 2017 , ... SSCI, a division of Albany Molecular Research, ... representing a milestone achievement. , As an industry-leading provider of ... served as expert and fact witnesses to assist our clients to perform infringement ...
(Date:7/27/2017)... ... ... Angeles leg of the US movie premier of the Man in the Camo Jacket will ... Davis Theater inside the Grammy Museum Located in downtown Los Angeles in the LA Live ... musician, Mike Peters (of The Alarm), his rise to fame, battle with cancer and inspiring ...
Breaking Medicine News(10 mins):
(Date:7/24/2017)... July 24, 2017  Diplomat Pharmacy, Inc. (NYSE: ... its second quarter 2017 operating results on Monday, August ... to follow at 5:00 p.m. ET. ... to a live broadcast of the conference call by ... participant code 51641230 approximately 15 minutes prior to the ...
(Date:7/20/2017)... 2017  Prime Therapeutics LLC (Prime) released this statement from ... today,s Institute for Clinical and Economic Review,s (ICER) public ... and value of abuse-deterrent formulations (ADF) of opioids. Prime was ... the meeting. "The ... to the use of abuse-deterrent formulations (ADF) in opioids in ...
(Date:7/14/2017)... VEGAS , July 13, 2017 It should ... United States is in the midst of a ... Control , since 1999, the number of overdose deaths from ... "resulting in over half a million dead from 2001 to ... codeine, oxycodone, and hydrocodone has similarly quadrupled, drawing a compelling ...
Breaking Medicine Technology: