Navigation Links
Eating smart: Researcher studies foods, dietary supplements that may reduce risk of prostate cancer
Date:1/23/2012

MANHATTAN, KAN. -- A Kansas State University professor is turning to nutrition to tackle prostate cancer.

Brian Lindshield, assistant professor of human nutrition, is helping men make more informed diet decisions by studying foods and dietary supplements that may reduce the risk of prostate cancer. Prostate cancer is one of the most common forms of cancer among men in the United States.

"I'm interested in researching ways to prevent prostate cancer rather than how to treat it after a person has been diagnosed with cancer," Lindshield said.

The goal of Lindshield's research is twofold: He is performing basic studies that examine specific drugs as well as dietary supplements. His research has been supported by grants from the Johnson Cancer Research Center and the National Institute of Health Center of Biomedical Research Excellence, or COBRE, for epithelial function in health and disease.

One project focuses specifically on two drugs -- finasteride and dutasteride -- that are used to treat benign prostatic hyperplasia, or BPH, which is an enlargement of the prostate. Both drugs inhibit enzymes that convert the male hormone testosterone to a more potent form, called dihydrotestosterone, or DHT. Finasteride inhibits one of these enzymes, while dutasteride inhibits both of these enzymes.

Because these drugs inhibit DHT production, they may also prevent the development of prostate cancer. Several clinical trials have shown that both drugs decrease prostate cancer incidence, but at a cost.

"Among the men who took these drugs and still got prostate cancer, more of them had a high-grade or more aggressive prostate cancer," Lindshield said. "It's kind of a double-edged sword. These drugs can lower the risk of developing prostate cancer, but they also might lead to worse outcomes for men who do develop the disease."

That's where Lindshield's research fits in: He is comparing finasteride and dutasteride to see if one is better than the other.

"Our hypothesis is that dutasteride is a better option because it inhibits both enzymes while finasteride only inhibits one," Lindshield said.

For a second project, Lindshield is studying different dietary supplements that affect prostate cancer risk. He is focusing on extract from saw palmetto, a type of shrub that looks similar to a palm tree. Many men take saw palmetto extract because it is believed to benefit prostatic health and inhibit the same enzymes as finasteride and dutasteride. But a lack of regulation and research surrounding saw palmetto has not provided clear insight into whether taking the extract is beneficial.

"The supplement market is kind of the wild world of whatever goes," Lindshield said. "It is not regulated in the United States, so many different kinds of saw palmetto extracts exist."

Lindshield wants to determine the composition of different saw palmetto extracts and determine which ones may be most effective. So far the researchers have collected various saw palmetto extracts -- from small liquids to capsules. They are beginning to measure the active components of each of the extracts and then will look at different extracts to see if they are effective in decreasing prostate cancer.

"We want to look at how they affect growth of prostate cancer cells and inhibit the enzymes that produce DHT," Lindshield said.

While both projects are in the early stages, Lindshield hopes that they can provide insight into ways that men can reduce their risk of prostate cancer.


'/>"/>

Contact: Brian Lindshield
blindsh@k-state.edu
785-532-7848
Kansas State University
Source:Eurekalert

Related medicine news :

1. Study carried out into biological risks of eating reptiles
2. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
3. Legislating to promote healthy eating and physical activity
4. First Breakthrough in Water Heating Technology!
5. Personalizing cancer: Creating biomarkers from tumor DNA
6. Figure Skating Standards Foster Eating Disorders, Says Kimberly Dennis, M.D.
7. Remuda Ranch Programs for Eating and Anxiety Disorders Sponsors a Special Edition of the Award-Winning Documentary America The Beautiful
8. Taxing unhealthy foods may encourage healthier eating habits
9. Savor: Mindful Eating, Mindful Life -- The Definitive Guide to Changing the Way People Eat and Live
10. Europes top football venues are not prepared for treating spectators who suffer heart attacks
11. Seattle Suttons Healthy Eating Sponsoring The Biggest Loser Chicago Casting Call
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... 2016 , ... DDi , a Makro company, makes ... its expertise in eClinical Solutions. DDi has built its solution competency with a ... global clients. DDi provides smarter technology for Clinical Development, Regulatory and Enterprise domains ...
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of ... Evangeline Parishes. The purpose of these scholarships is to encourage applicants to pursue ... to seek employment within these two parishes. , “We have available jobs in ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, 2016 , ... CDRH Enforcement Trends: , ... http://www.fdanews.com/cdrhenforcementtrends , As Winston Churchill said, “Those who don’t learn ... 2015 will show what to expect when they come knocking this year. But that takes ...
(Date:2/12/2016)... Angeles, CA (PRWEB) , ... February 12, 2016 , ... ... With a hectic schedule, a demanding job, and no time to decompress, Rabinowitz found ... she dedicated herself to meditation for its impact on her life, implementing a 20-minute-per-day ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ... Zuckerberg San Francisco General Hospital on April 5-7. The series is a multi-day, ... new habits. The workshops cover a broad range of topics, including coaching skills, ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016  Sequent Medical, Inc. announced today that ... evaluate the safety and effectiveness of the WEB™ Aneurysm ... intracranial aneurysms.  Prof Laurent Spelle , MD, Head ... Paris, France and Principal Investigator of the ... France and Germany.  Although patients with ruptured ...
(Date:2/12/2016)... 2016  OMS Supply, a large provider of oral ... today the recent launching of their new company website. ... features that enhance the user experience and enable practitioners ... --> --> Despite the ... that started in early 2016, they have already made ...
(Date:2/11/2016)... Feb. 11, 2016 - ... in Personalized Medicine and Cancer Therapy. - European ... Diagnostic Testing Markets. - Key Diagnostic Testing Markets. ... Molecular Diagnostics in Genetic Testing. - Molecular Diagnostics ... - Over-the-Counter Diagnostic Products World Markets. - ...
Breaking Medicine Technology: