Navigation Links
Eating a high-fat diet may rapidly injure brain cells that control body weight
Date:6/8/2011

Obesity among people who eat a high-fat diet may involve injury to neurons, or nerve cells, in a key part of the brain that controls body weight, according to the authors of a new animal study. The results will be presented Tuesday at The Endocrine Society's 93rd Annual Meeting in Boston.

"The possibility that brain injury may be a consequence of the overconsumption of a typical American diet offers a new explanation for why sustained weight loss is so difficult for most obese individuals to achieve," said presenting author Joshua Thaler, MD, PhD, a faculty member with the Diabetes and Obesity Center of Excellence at the University of Washington in Seattle.

Thaler and his colleagues studied the brains of rodents for the short-term and long-term effects of eating a high-fat diet. After giving groups of six to 10 rats and mice a high-fat diet for periods from one day to eight months, the researchers performed detailed biochemical, imaging and cell sorting analyses on the animals' brains.

Within the first three days of consuming a diet that had a similar fat content to the typical American diet, rats consumed nearly double their usual daily amount of calories, Thaler reported. Rats and mice fed the high-fat diet gained weight throughout the study. These rodents developed inflammation in the hypothalamus, the part of the brain containing neurons that control body weight. At the same time, a group of support cells called glia and scavenger cells called microglia accumulated in the hypothalamus and appeared to become activated. Although this collective response to brain inflammationcalled gliosissubsided days later, it recurred after four weeks.

"Gliosis is thought to be the brain equivalent of wound healing and is typically seen in conditions of neuronal injury, such as stroke and multiple sclerosis," Thaler said. "We speculate that the early gliosis that we saw may be a protective response that fails over time."

In their experiments, Thaler said they also detected damage to, and eventual loss of, critical weight-regulating neurons. These neurons, called pro-opiomelanocortin (POMC) neurons, were reduced in number by month 8 of the high-fat diet in mice, according to Thaler. These results were not present in same-age rodents fed standard chow.

It is not yet clear whether this presumed neuronal injury is permanent, but it may contribute to weight gain, he stated.

This research, which was funded by the National Institute of Diabetes and Digestive and Kidney Diseases, provides a new potential target for obesity treatment, Thaler concluded.

"If new medicines can be designed that limit neuron injury during overeating, they may be effective in combating the obesity epidemic," he said.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Study carried out into biological risks of eating reptiles
2. Bariatricfurnishings.com Launches Unique Eco-friendly Seating for Health Care, Hospitality, Assisted Living Centers, and Home Use at Competitive Prices
3. Legislating to promote healthy eating and physical activity
4. First Breakthrough in Water Heating Technology!
5. Personalizing cancer: Creating biomarkers from tumor DNA
6. Figure Skating Standards Foster Eating Disorders, Says Kimberly Dennis, M.D.
7. Remuda Ranch Programs for Eating and Anxiety Disorders Sponsors a Special Edition of the Award-Winning Documentary America The Beautiful
8. Taxing unhealthy foods may encourage healthier eating habits
9. Savor: Mindful Eating, Mindful Life -- The Definitive Guide to Changing the Way People Eat and Live
10. Europes top football venues are not prepared for treating spectators who suffer heart attacks
11. Seattle Suttons Healthy Eating Sponsoring The Biggest Loser Chicago Casting Call
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... , ... The annual time frame to change Medicare health and prescription drug ... 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their current plan to ... make changes during this period order for their new policy to go into effect ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... of two ostomy patients, standing as living proof that attitude and determination can ... diseases and issues that spike around the holidays. This campaign will offer patients ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... of "Cardiovascular Health" in USA Today, which covers the innovative treatments, therapeutic technologies, ... while maintaining fulfilling lives. “We are prolonging life 6 years in the last ...
(Date:12/2/2016)... ... December 02, 2016 , ... Universal Medical Systems, Inc. ... the first company to offer robotic imaging to veterinary medicine is sponsoring the ... 941 for the American Association of Equine Practitioners 62nd Annual Convention from December ...
(Date:12/2/2016)... Texas (PRWEB) , ... December 02, 2016 , ... Yisrayl ... that delves into how this current generation fits into Bible Prophecy. Yisrayl says this ... various facts pointing to this conclusion, showing how the details line up exactly with ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2, 2016  The Addiction Treatment Advisory Group ... Managed Care Pharmacy (AMCP), has released detailed findings ... the opioid addiction crisis, including through improved access ... ATAG,s newly released paper, "The Role of ... addresses many issues around gaps and barriers to ...
(Date:12/2/2016)... , Dec. 2, 2016  Maxor National Pharmacy Services, LLC ... Pharmaceutical Specialties, Inc. ("PSI").  The combination of Texas ... Georgia -based PSI bring together both company,s clinical expertise ... and payers an industry-leading specialty pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... R.I. , Dec. 2, 2016 CVS ... its annual Analyst Day in New York City on Thursday, December 15, ... CVS Health leadership team will provide an in-depth review ... enhance shareholder value. The company will also discuss 2017 ... and video webcast of the event will be broadcast ...
Breaking Medicine Technology: