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How you eat counts, study says, but nervous system also dictates weight gain, loss

WEDNESDAY, June 4 (HealthDay News) -- Your nerves, rather than your eating habits, may have a more direct role in whether you are fat or thin, according to new research.

A study on worms shows that serotonin levels in the nervous system influence feeding and fat. Serotonin, a neurotransmitter, also acts independently to control eating and what your body does with those calories once they've been consumed, the study said.

"It says that the nervous system is a key regulator coordinating all energy-related processes through distinct molecular pathways," Kaveh Ashrafi, of the University of California, San Francisco, said in a prepared statement. "The nervous system makes a decision about its state leading to effects on behavior, reproduction, growth and metabolism. These outputs are related, but they are not consequences of each other. It's not that feeding isn't important, but the neural control of fat is distinct from feeding."

Ashrafi said that given serotonin's ancient evolutionary origins, you can apply what's learned from the worms to humans.

"From a clinical perspective, this may mean you could develop therapeutic strategies to manipulate fat metabolism independently of what you eat," he said. "Now, the focus is primarily on feeding behavior. As important as that is, it's only part of the story. If the logic of the system is conserved across species, a strategy that focuses solely on behavior can only go so far. It may be one reason diets fail."

The findings were published in the June issue of Cell Metabolism.

At its most basic level, fat regulation is the balance between energy intake and expenditure; however, Ashrafi said the physiology is very complicated.

In the worms, serotonin affected feeding by involving nerve receptors not normally required for fat control. The by
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