Navigation Links
Early warning: PSA testing can predict advanced prostate cancer
Date:2/14/2008

Researchers who showed that a single prostate specific antigen (PSA) test at age 50 or under could predict the presence of prostate cancer up to 25 years later, (regardless of clinical significance) have now found that a single PSA can be used to predict advanced prostate cancer.

The findings, published in the online open access journal BMC Medicine, should help physicians identify which men would benefit from intensive screening.

More men die with prostate cancer than from it and in many cases the quality or length of their lives are not affected. However, advanced prostate cancer has serious consequences, including death. Researchers from Memorial Sloan-Kettering Cancer Center, New York and Lund University, Sweden set out to investigate the ability of a single PSA test to predict a diagnosis of advanced prostate cancer in later life. Advanced cancer was defined as one where the cancer had spread locally beyond the prostate or to other parts of the body at the time of diagnosis.

The team studied blood samples collected between 1974 and 1986 as part of a large population-based study of middle-aged men. The study cohort included 161 men who had been diagnosed with advanced prostate cancer by 1999 and men of a similar age who had not developed cancer by that time. The results showed that the total PSA level was an accurate predictor of advanced cancer diagnosis in later life. The majority (66%) of advanced cancers were seen in men whose PSA levels were in the top 20% (total PSA > 0.9 ng/ml). The median time from blood test to cancer diagnosis was 17 years.

The authors write: A single PSA test taken at or before age 50 is a very strong predictor of advanced prostate cancer diagnosed up to 25 years later. This suggests the possibility of using an early PSA test to risk stratify patients so that men at highest risk are the focus of the most intensive screening efforts.

Targeting screening could allow physicians to intervene when the cancer is at an early stage and still curable. It could also reduce overdiagnosis and unnecessary treatment in men with benign tumours.


'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Related medicine news :

1. ReBuilder Medical Technologies, Inc. Announces 2007 Sales Nearly Doubled Sales in 2006
2. Cancer Drug Works Against MS in Early Trial
3. Yale test detects early stage ovarian cancer with 99 percent accuracy
4. New Survey Suggests Confusion, Lack of Awareness About Heart Failure Could Be Preventing Critical Early Detection and Treatment
5. JCI online early table of contents: Feb. 7, 2008
6. New study suggests link between environmental toxins and early onset puberty in girls
7. A Reminder to Parents: Early Dental Visits Essential to Childrens Health
8. Rheumatoid arthritis sends many into early retirement
9. Early detection critical in treating pediatric thyroid cancer
10. NFL Linemen Predisposed to Cardiovascular Disease; Early Detection is Key to Getting and Staying Healthy
11. Protein Linked With Poor Prognosis in Early-Stage Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the ... analysis system called the HORIZON at MIBio 2017 in ... subvisible and visible particulate matter in biopharmaceutical samples with unprecedented speed ... of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... CHICAGO , Sept. 28, 2017 Hill-Rom ... quarter 2017 earnings conference call and webcast on Friday, ... 8:00 a.m. (EDT) and ending at approximately 8:30 a.m. ... to discussing the company,s 2017 financial performance and guidance ... growth opportunities, initiatives to enhance operational performance, and long-range ...
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
Breaking Medicine Technology: