Navigation Links
Early treatment of systemic onset JIA with anakinra restores the IL-18 response
Date:6/12/2009

d. Our study has shown that, once NK cell levels and function are restored to normal, the cytokine pathway specifically involving IL-18 is restored, which elicited a good clinical response in this patient group. The underlying processes involved in auto inflammatory diseases are complex and these results suggest a potential new treatment strategy for children with newly-diagnosed SoJIA."

Researchers in this study recruited ten children with newly-diagnosed SoJIA, initiating treatment with anakinra prior to steroids. During a six month follow-up period, absolute NK cell numbers and function, cytokine profiles, and NK cell response after IL-18 stimulation, were monitored.

Following treatment, clinical parameters such as fever, exanthema and arthritis resolved after 3 days. A rapid decrease in ESR (erythrocyte sediment rate; an indication of inflammation), CRP (C reactive protein; a marker for inflammation), ferritin (a test of iron stores in the body) and sIL-2R (soluble interleukin 2 receptor) was observed. No differences of IL-1alpha, IL-1beta and IL-33 were observed, but levels of IL-6, IL-1RA and IL-18 returned to normal, as observed in healthy controls. During follow-up, two patients flared following anakinra treatment.

*NK cells are a type of cytotoxic lymphocyte that constitute a major component of the innate immune system. NK cells play a major role in the rejection of tumors and cells infected by viruses. The cells kill by releasing small cytoplasmic granules of proteins called perforin and granzyme that cause the target cell to die by apoptosis or necrosis.


'/>"/>

Contact: Rory Berrie
eularpressoffice@uk.cohnwolfe.com
44-789-438-6425
European League Against Rheumatism
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pot bellies linked to early signs of cardiovascular disease
2. Eye-staining technique offers early detection for dry eye syndrome
3. Early Weight Loss in Women Linked to Dementia
4. Isolation of a new gene family essential for early development
5. U of M study: Early treatment can reverse heart damage
6. Gerresheimer to be Included in the SDAX Early Decision on Inclusion in the MDAX on September 5, 2007
7. Rock N Roll: Sex, Drugs and an Early Exit
8. Pop stars more than twice as likely to die an early death
9. Exercise and yoga improves quality of life in women with early-stage breast cancer
10. Research says doctors gender may hinder early diagnosis of heart disease in women
11. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... ... July 02, 2015 , ... As Americans celebrate the Fourth of ... skin cancer is on the rise. July is UV Safety Month, and physicians at ... the importance of getting skin checks. Experts say most skin cancers can be found ...
(Date:7/2/2015)... CITY, GA (PRWEB) , ... July 02, 2015 , ... ... their newest innovation in compression socks designed for men. , For style that’s ... socks into their daily routine. This is great news for men everywhere because a ...
(Date:7/2/2015)... , ... July 02, 2015 , ... The ZAC Foundation, ... 2015 swim season with important lessons on how to stay water safe with the ... Couldn’t, Wouldn’t Swim, authored by The ZAC Foundation co-founders, follows Zeke’s water safety journey. ...
(Date:7/2/2015)... ... July 02, 2015 , ... When ... met for the late June Web-based session, the speakers discussed the importance of ... managing high-risk patients through coordinated care. , During the session, participants learned the ...
(Date:7/2/2015)... CA (PRWEB) , ... July 02, 2015 , ... ... of Dr. Divakar R. Krishnareddy, M.D., to the orthopedic and spine surgery team ... disc herniations, sprains, strains, bursitis, and tendonitis. Along with the spine and spine ...
Breaking Medicine News(10 mins):Health News:Local Physicians Warn of Holiday Health Hazards 2Health News:Local Physicians Warn of Holiday Health Hazards 3Health News:Local Physicians Warn of Holiday Health Hazards 4Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 3Health News:The ZAC Foundation Kicks Off Summer and July 4th Weekend with Complimentary Children’s E-Book on Water Safety 2Health News:The ZAC Foundation Kicks Off Summer and July 4th Weekend with Complimentary Children’s E-Book on Water Safety 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 2Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 4Health News:Healthpointe Welcomes Dr. Divakar R. Krishnareddy to its Orthopedic Team in Anaheim 2Health News:Healthpointe Welcomes Dr. Divakar R. Krishnareddy to its Orthopedic Team in Anaheim 3
... Business Services Inc. (Pink Sheets: APRO) recently announced, that in ... now offers its PEO staffed employees high-quality health care coverage, ... , "I am pleased to report that the benefit services, ... new plans, with new members signing on a continuing basis," ...
... , Multi-Product Collaboration Valued Potentially at More Than $500 ... FRANCISCO, Calif., June 30 Wyeth Pharmaceuticals, a division ... Biosciences, Inc. today announced that the two companies have ... and commercialization of Factor VIIa products to treat hemophilia ...
... Connectyx (Pink Sheets: CTYX) - Connectyx Technologies Holdings Group, Inc. ... issued an open letter to shareholders available for viewing on ... The letter addresses many of the events that have ... including the addition of several prominent individuals to the management, ...
... June 30 Health systems should have bigger,incentives and rewards ... , Healthcare systems are large, complex ... in healthcare is not impossible - new,ideas and approaches have ... consumers of healthcare and those who work in the,system. , ...
... of information about the disease in the Hispanic community , ... "Baldo" will feature a storyline on diabetes in order to ... Hispanics. , The comic strip features a Hispanic teen named ... June 30, Baldo will learn his father has diabetes. The ...
... than depression among moms, experts say , TUESDAY, June 30 ... baby can be just as much the result of dad,s ... found that depression among mothers can be related to excessive ... researchers said that little was known about whether fathers, emotions ...
Cached Medicine News:Health News:Allegiant Professional Business Services Inc. Signs New Members to Its PPO Health Insurance Plan. Annual Revenues Projected to Increase by $5M. 2Health News:Wyeth Pharmaceuticals and Catalyst Biosciences Announce Agreement to Develop and Commercialize Factor VIIa Products 2Health News:Wyeth Pharmaceuticals and Catalyst Biosciences Announce Agreement to Develop and Commercialize Factor VIIa Products 3Health News:Wyeth Pharmaceuticals and Catalyst Biosciences Announce Agreement to Develop and Commercialize Factor VIIa Products 4Health News:Wyeth Pharmaceuticals and Catalyst Biosciences Announce Agreement to Develop and Commercialize Factor VIIa Products 5Health News:Connectyx Technologies Holdings Group's CEO Gives Shareholders a Summary of Events for First Half of 2009 and Announces Teleconference Call on July 9th to Discuss Future Strategy 2Health News:Connectyx Technologies Holdings Group's CEO Gives Shareholders a Summary of Events for First Half of 2009 and Announces Teleconference Call on July 9th to Discuss Future Strategy 3Health News:Sad Dads May Lead to Crying Infants 2
(Date:7/2/2015)... FRANCISCO , July 2, 2015  The Green ... ), the world,s first HIPAA compliant mobile app that ... of farm-to-table fresh medical marijuana, announced today that their ... Unlike Eaze, Meadow and more than half a ... the last year, Loud Cannabis is unique in that ...
(Date:7/2/2015)... DALLAS , July 2, 2015 ... Type (Homofermentative & Heterofermentative), Species (Lactobacillus, Pediococcus & Enterococcus), ... Trends and Forecast to 2020", Silage Inoculants & Enzymes ... at a CAGR of 4.0% from 2015 to 2020. ... F igures spread through 194 P ...
(Date:7/2/2015)... July 2, 2015  The Commission for Certification ... ASHP, an organization that represents pharmacists in acute ... of continuing education for recertification of Certified Geriatric ... geriatric programs for this purpose.  ASHP will join ... providers for the CCGP Professional Development Program. ...
Breaking Medicine Technology:New Cannabis Delivery App Gets Product to Patient in Under 7 Minutes 2Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 2Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 3Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 4Commission for Certification in Geriatric Pharmacy Adds ASHP as Professional Development Program Provider 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: