Navigation Links
Early switch from IV to oral meds is effective for children with acute bone infection
Date:2/12/2009

When treating hospitalized children with acute osteomyelitis--a bacterial bone infection--an early changeover from intravenous (IV) antibiotic delivery to oral antibiotics is just as effective as continuing the IV therapy, according to pediatric researchers.

In addition, the oral drugs are more convenient for children and families, and avoid a major drawback of IV use: increased risk of complications from using central catheters, such as infections or breaks in the catheter.

A study team from The Children's Hospital of Philadelphia analyzed hospital records for nearly 2,000 children treated at 29 U.S. pediatric hospitals between 2000 and 2005. Their report appeared in the February issue of Pediatrics. "There had been previous reports with small numbers of patients suggesting that early transition to oral antibiotics was safe and effective," said study leader Theoklis Zaoutis, M.D., M.S.C.E., an infectious diseases specialist at the Center for Pediatric Clinical Effectiveness of Children's Hospital. "This was the first large study of outcomes to directly compare the two practices."

Acute osteomyelitis annually affects at least one in 5,000 children under age 13 in the United States, and results in one percent of all pediatric hospitalizations. Typically caused by the common bacteria Staphylococcus aureus, osteomyelitis usually appears as a fever with some discomfort in a child's leg or arm resulting from the bone infection. The average age of children with the condition is five years.

The traditional treatment has been to supply antibiotics through a central venous catheter over a four- to six-week period after the child returns home from the hospital. Alternatively, children are first treated with IV antibiotics for less than a week, then sent home with oral antibiotics.

In the current study, some 5 percent of the 1,021 children receiving the prolonged IV antibiotic had to return to the hospital for further treatment, compared to 4 percent of the 948 children receiving oral medicine. "The risk of treatment failure was not significantly different between the two groups," said Zaoutis, "but approximately 4 percent, of the children receiving the prolonged IV therapy had complications related to the central venous catheter."

Zaoutis's study found wide variability in hospital practices, with some children's hospitals switching over 90 percent of their osteomyelitis patients to oral drugs, and other hospitals using early transition in less than 10 percent of patients. "This study provides evidence that hospitals can orient their clinical guidelines toward early transition to oral medication for acute osteomyelitis in children," added Zaoutis. He cautioned that the study focused on children with uncomplicated infections, and switching to oral therapy may not be appropriate for complicated infections or chronic osteomyelitis.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Women who drink lots of soda at higher risk for early kidney disease
2. Best Practice Database adds Research Highlighting the Value of Internal Consulting and Early-Stage Commercialization Groups in the Pharmaceutical Industry
3. Pearly Penile Papule Patients Can Successfully Be Treated with Targeted CO2 Technology at La Jolla Cosmetic Surgery Centre
4. The New Crystalens HD Gives Many Baby Boomers and Seniors an Opportunity to See Clearly at All Distances while Reducing or Eliminating the Need for Glasses
5. Zinc May Counter Effects of Alcohol in Early Pregnancy
6. Early Detection Methods for Pancreatic Cancer Urgently Needed: A Statement From the Pancreatic Cancer Action Network
7. GlycoMeds Discovery Yields Early Warning Test for Cancer
8. Regular physical activity linked to better quality of life in early-stage lung cancer survivors
9. Workforce shortages in mammography could threaten early detection rates for breast cancer
10. Umbilical cord protein analysis detects early onset infection
11. Study shows younger women with endometrial cancer can safely keep ovaries, avoid early menopause
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
(Date:6/24/2016)... ... ... recruitment firm Slone Partners is pleased to announce the placement of Suzanne ... of North American Capital Sales at HTG Molecular . , In ... commercialization of the HTG EdgeSeq system and associated reagents in North America. , Headquartered ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, a provider ... and other difficult to transfect cells, announces its launch of the PluriQ™ G9™ ... Editing System is a complete system for culturing and transfecting human pluripotent ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
Breaking Medicine Technology: