Navigation Links
Early signs of heart disease in preadolescent children with type 1 diabetes
Date:2/14/2011

Cardiovascular disease is the leading cause of death in patients with diabetes. Patients with type 1diabetes have a 200 percent to 400 percent greater chance of developing cardiovascular disease than those without diabetes. Medical College of Wisconsin researchers at Children's Hospital of Wisconsin discovered the early signs of cardiovascular disease are likely to manifest before the onset of puberty in many children with diabetes.

Those findings are published in the February 2, 2011 online version of Diabetes Care and will be in the March 2011 issue of Diabetes Care.

Led by Dr. Ramin Alemzadeh, professor of pediatrics at the college and pediatric endocrinologist at Children's Hospital of Wisconsin, and Senior Clinician Scientist at Children's Hospital's Max McGee Juvenile Diabetes Research Center, the researchers studied 21 preadolescent children (avg. age 8.5 years) with type 1 diabetes, and compared that group to 15 healthy siblings. Investigators looked at flow-mediated dilatation (FMD), a gauge of the health of a major blood vessel of the upper arm artery, in both groups. FMD percentage (FMD%,) is a way to measure any stiffening of the blood vessels; stiffening blood vessels is an early precursor of cardiovascular disease.

Children who had high blood pressure, family history of high cholesterol or premature cardiovascular disease from other causes were excluded. Blood samples were collected from all participants to monitor cholesterol and sugar levels.

When tested, the blood vessels of children with type 1 diabetes had a lower FMD% change, which means their blood vessels were less expandable than the control group suggesting that higher circulating glucose results in increased rigidity of blood vessels independent of serum cholesterol levels. The patients with diabetes also had vascular inflammation, which is a known harbinger of future cardiovascular risk. Long-term studies are needed to evaluate the progression of those vascular changes through puberty and beyond.


'/>"/>

Contact: Maureen Mack
mmack@mcw.edu
414-955-4744
Medical College of Wisconsin
Source:Eurekalert

Related medicine news :

1. JCI online early table of contents: Feb. 14, 2011
2. Early Birth Risky, Even With Fully Developed Lungs: Study
3. Nearly 25% of Women With Early Ovarian Cancer Not Given Recommended Biopsies
4. Removing Many Lymph Nodes in Early Breast Cancer Not Always Needed: Study
5. Researchers predict nearly 1.3 million cancer deaths in Europe in 2011
6. Universal Flu Vaccine Shows Promise in Early Trial
7. Giving Baby Solid Foods Too Early Linked to Obesity Later
8. JCI online early table of contents: Feb. 7, 2011
9. Urine-sniffing dogs: Early detection of prostate cancer
10. Obesity Has Nearly Doubled Worldwide Since 1980: Report
11. Early infusion of donor T cells prevents graft versus host disease in blood cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... 17, 2017 , ... Dr. Charles W. Grimsley’s new book ... paperback, 9781498497626; $7.99, eBook, 9781498497633) focuses on the treatment of veterans diagnosed with ... forgiveness, through a progressive journey toward healing. This book will help readers learn ...
(Date:8/17/2017)... ... , ... Advice Media, the industry leader in digital marketing for medical practices, has been recognized ... included in the Inc. 5000 for the second time in two years. Shawn Miele, Chief ... 5000 rankings for the second year in a row. It’s extremely difficult to make this ...
(Date:8/16/2017)... ... 16, 2017 , ... Summer days spent with family are priceless. Since August ... suggestions for enjoying the season of sunshine. Add trying something new to this summer’s ... join in on the fun. , Try Something New , Choose ...
(Date:8/16/2017)... ... ... Ten outstanding teachers in the Greater Houston area will be named one ... by a Houston Texans player, two tickets to a Texans game, and other prizes. ... texanschecking.com/stars to nominate their favorite teacher with an essay of no more than 500 ...
(Date:8/16/2017)... ... , ... In a recent survey, eighty-two percent of women reported having cellulite, ... can't always be eliminated by diet and exercise alone, and now for the first ... Dr. Kenneth Rothaus has recently added Cellulaze™ to his practice in New ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... TEL AVIV, Israel, Aug. 8, 2017  BioLineRx Ltd. ... and immunology, today reports its financial results for the ... and achievements during the second quarter 2017 and to ... on multiple clinical development programs for the Company,s lead ... Phase 3 pivotal study with BL-8040 as novel stem ...
(Date:8/7/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ) today announced ... Aug. 7, 2017. ... and will serve as president emeritus during a planned, 90-day ... multiple leadership roles since he joined Diplomat with the acquisition ... decisive, strategic leadership which continues to benefit our patients and ...
(Date:8/4/2017)... Aug. 3, 2017  Agragen, LLC, a ... in the biopharmaceutical, nutraceutical, and aquacultural feed sectors, ... its lead drug candidates, AGR131.  This drug is ... from the blood of patients suffering from inflammatory ... bowel disease. ...
Breaking Medicine Technology: