Navigation Links
Early sign of Alzheimer's reversed in lab
Date:11/30/2011

One of the earliest known impairments caused by Alzheimer's disease - loss of sense of smell can be restored by removing a plaque-forming protein in a mouse model of the disease, a study led by a Case Western Reserve University School of Medicine researcher finds.

The study confirms that the protein, called amyloid beta, causes the loss.

"The evidence indicates we can use the sense of smell to determine if someone may get Alzheimer's disease, and use changes in sense of smell to begin treatments, instead of waiting until someone has issues learning and remembering," said Daniel Wesson, assistant professor of neuroscience at Case Western Reserve and lead investigator. "We can also use smell to see if therapies are working."

A description of the research is published in the Nov. 2 issue of The Journal of Neuroscience.

Smell loss can be caused by a number of ailments, exposures and injuries; but since the 1970s, it has been identified as an early sign of this disease. The new research shows how and where in the brain this happens, and that the impairment it can be treated.

"Understanding smell loss, we think, will hold some clues about how to slow down this disease," Wesson said.

There is currently no effective treatment or cure for the disease, marked by eroding senses, cognition and coordination, leading to death.

Currently 5.3 million Americans suffer from Alzheimer's and the number is expected to triple to 16 million by 2050, according to the Alzheimer's Association.

Wesson worked with Anne H. Borkowski, a researcher at the Nathan S. Kline Institute in Orangeburg, N.Y., Gary E. Landreth, professor of neuroscience at Case Western Reserve School of Medicine, and Ralph A. Nixon, Efrat Levy and Donald A. Wilson, of the New York University School of Medicine.

They found that just a tiny amount of amyloid beta too little to be seen on today's brain scans - causes smell loss in
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Could Weight Loss Be Early Sign of Alzheimers?
2. JCI online early table of contents: Nov. 21, 2011
3. Hispanics With Diabetes Urged to Get Yearly Foot Care
4. Ovary-Saving Hysterectomy Linked to Early Menopause
5. US preterm birth rate under 12 percent, the lowest level in nearly a decade
6. Early breast cancer detection saves lives
7. Male breast cancer patients stop taking tamoxifen early because of drug-related side effects
8. Cholesterol Drug Shows Promise in Early Research
9. JCI online early table of contents: Nov. 14, 2011
10. Early, intensive therapy for type 1 diabetes prevented kidney disease in long-term study
11. New funding will help researchers learn how preschoolers move, battle early child obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... scientists and their partners have found that their proprietary ... transmission of multiple sexually transmitted infections (STIs) in both ... virus 2 (HSV-2), and human papillomavirus (HPV). The USAID-funded ... is effective against multiple strains of HIV, and has ... three viruses of at least eight hours prior to ...
(Date:4/17/2014)... therapy improves general blood flow and alleviates muscle ... researchers at the University of Illinois at Chicago. ... print in the Archives of Physical Medicine ... vascular function in people who had not exercised, ... of their level of physical activity. , Improved ...
(Date:4/17/2014)... of Canadians surveyed said they would participate in public ... of genetic conditions, only 80 per cent said they ... sequence their newborns, genomes.,Most newborns in North America have ... two of life in which a tiny amount of ... about five to 54 conditions, depending on the state ...
(Date:4/17/2014)... as the leading weapon against the deadly disease could ... research indicating it simply needs to be administered differently. ... cheap anti-malarial drug chloroquine in treating and preventing the ... half a million people each year around the world. ... to chloroquine, but research carried out at the Australian ...
(Date:4/16/2014)... Ariz. April 15, 2014 The Translational Genomics ... at their annual Founders Dinner for their support of ... event took place March 28 in Scottsdale. , Catherine ... Ivy Foundation, received TGen,s John S. McCain Leadership Award, ...
Breaking Medicine News(10 mins):Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2Health News:Massage therapy improves circulation, eases muscle soreness 2Health News:Researcher looks at public perceptions around newborn testing 2Health News:Researcher looks at public perceptions around newborn testing 3Health News:Scientists find new way to fight malaria drug resistance 2Health News:TGen honors Catherine Ivy and Craig Jackson with Leadership; Collaborative Spirit awards 2
... of interoperable Health Information Technology (HIT) will be ... the U.S. healthcare system," Yul D. Ejnes, MD, FACP, ... Health today. "Unfortunately, without adequate financial incentives, small ... technological curve." Dr. Ejnes, a member of the Board ...
... launches first of three-part series, MONTCLAIR, N.J., July ... the launch of an educational Webcast series on,chronic pain ... chronic pain sufferer, Nikki Stone. The first in the,three-part ... You Back" is available today at http://www.painawareness.org ., ...
... July 24 Colombia has appointed Dallas sports,chiropractor, Dr. ... medical team,during the upcoming Olympic Games in Beijing. Dr. ... worked with the Costa,Rican team for the 2007 Pan ... a privilege to bring the profession to an international ...
... BURLINGTON, Mass., July 24 Palomar Medical,Technologies, Inc. (Nasdaq: ... devices for hair removal and other cosmetic treatments, will,hold ... financial,results on Thursday, July 31, 2008 at 11:30AM Eastern ... 362-4831 at 11:20 AM Eastern Time on,that day. The ...
... The University of Queensland is helping to increase medical ... advanced clinical training facility. , UQ,s Rural Clinical ... and Learning Centre to its portfolio, with space to ... adjacent to the Toowoomba Base Hospital in West Street, ...
... new research facility is planned to enable unprecedented understanding ... shape human behaviour. The 28.5 million funding comes ... Universities and Skills (DIUS), and will be used for ... be a collaboration between the Economic and Social Research ...
Cached Medicine News:Health News:ACP says Medicare should increase payments for physicians that use HIT to improve quality 2Health News:Video: Olympic Games Gold Medalist Nikki Stone Joins Chronic Pain Experts in Educational Webcasts 2Health News:Video: Olympic Games Gold Medalist Nikki Stone Joins Chronic Pain Experts in Educational Webcasts 3Health News:Video: Olympic Games Gold Medalist Nikki Stone Joins Chronic Pain Experts in Educational Webcasts 4Health News:Video: Olympic Games Gold Medalist Nikki Stone Joins Chronic Pain Experts in Educational Webcasts 5Health News:Video: Olympic Games Gold Medalist Nikki Stone Joins Chronic Pain Experts in Educational Webcasts 6Health News:Video: Olympic Games Gold Medalist Nikki Stone Joins Chronic Pain Experts in Educational Webcasts 7Health News:Colombia Appoints Dallas Chiropractor to Olympic Team 2Health News:Palomar Medical Technologies to Host Second Quarter 2008 Financial Results Conference Call and Webcast on July 31, 2008 2Health News:New $4.2m UQ medical center to boost rural doctor numbers 2Health News:£28.5M investment for groundbreaking new research facility 2
(Date:1/15/2014)... 2014  Manufacturers, suppliers and distributors of innovative medical-related ... their most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the ... the most litigious industry sectors of cases involving ...
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness ... Fitness Center by the Medical Fitness Association, a non-profit ... achieve their full potential. The Cadence Fitness & Health ... western suburbs and second in the Chicagoland area. ...
(Date:1/15/2014)... 2014 Reportlinker.com announces that a new ... catalogue: Global Markets ... -- Focus on End Users ... A drug delivery system is ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
... organiser UBM Live , a division of UBM ... CPhI Japan events line-up that is set to return ... March, 2012. The Pharmatech Japan event, which focuses on ... veterinary and medical industries, will join the Japan Pharma ...
... Pharmaceuticals, Inc. (Nasdaq: AUXL ) today announced ... Capital Global Healthcare Conference to be held March 13-14, ... Sargent, Vice President, Investor Relations and Corporate Communications, is ... its product pipeline at 8:00 a.m. ET on Tuesday, ...
Cached Medicine Technology:New Pharmatech Event to be Introduced Alongside CPhI and P-MEC Japan 2New Pharmatech Event to be Introduced Alongside CPhI and P-MEC Japan 3Auxilium Pharmaceuticals to Present at the 2012 Barclays Capital Global Healthcare Conference 2Auxilium Pharmaceuticals to Present at the 2012 Barclays Capital Global Healthcare Conference 3Auxilium Pharmaceuticals to Present at the 2012 Barclays Capital Global Healthcare Conference 4
... Acid is a non-irritating rapid exfoliator. Lactic Acid ... to peel and exfoliating agents in skin care ... other exfoliators for a long period and want ... occurring human metabolite, and combined with the chemical ...
... is available in two innovative formulations: Level ... active). The Level I (40% active) formulation ... extract, which DCL scientists have identified and ... and calm the skin while the beneficial ...
... CosmoDerm and CosmoPlast are dermal fillers ... acne scars and other soft tissue contour ... of the lip border. The collagen in ... dermal tissue that is grown under controlled ...
... is a gel of ... species of bacteria, chemically ... suspended in phosphate,buffered saline ... and concentration of 20 ...
Medicine Products: