Navigation Links
Early menopause predicts a milder form of rheumatoid arthritis
Date:6/8/2012

Berlin, Germany, June 8 2012 : A new study presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, shows that early menopause predicts a milder form of rheumatoid arthritis (RA). New insights on factors influencing RA are good news for sufferers of the chronic inflammatory disease that currently affects over 2 million women in Europe. 1,2

The study, based on 134 incident RA cases, found that patients aged over 45 years with a history of early menopause were 50% less likely to develop severe RA (16% versus 35%) and more likely to develop a mild/moderate rheumatoid factor (RF) negative phenotype (58% versus 20%). There was no major difference in RA severity depending on oral contraceptive use or history of breast feeding. This study highlights that hormonal changes may influence pathways that are distinct from those leading to severe, progressive disease.

Dr. Mitra Pikwer from Skne University Hospital, Sweden, and lead study author commented: "We already know that hormonal factors may influence the risk of RA, but this is the first study we know of that investigates the impact of menopausal age on the severity of RA. This is an important breakthrough, both in helping us understand the impact that hormones may have on the development of this disease and potentially also in helping us predict the long-term prognosis for our patients."

The study identified patients who answered a questionnaire in a community based health survey (conducted between 1991 and 1996) and later developed RA. Information on hormonal predictors including breastfeeding history, history of oral contraceptive use and menopausal age (early menopause ≤45 years or normal/late menopause > 45 years) was obtained via the questionnaire. By a structured review of the patients medical records, relevant information such as use of disease modifying anti-rheumatic drugs (DMARDs) including biological treatment, radiographic erosions, rheumatoid factor (RF) status as well as Health Assessment Questionnaire (HAQ*) data was collected. These variables were added to the SPSS TwoStep Cluster Analysis in order to reveal natural groupings of RA severity.


'/>"/>

Contact: Candice Debleu
eularpressoffice@cohnwolfe.com
44-789-438-6425
European League Against Rheumatism
Source:Eurekalert

Related medicine news :

1. 9 in 10 Blacks With High Blood Pressure Have Early Heart Disease
2. Study Spots Early Warning Signal for Sudden Cardiac Death
3. A systems approach to preventing obesity in early life
4. Research With Dogs Points to Early Test for Arthritis
5. Early Study Hints at Link Between Certain Sunscreens, Endometriosis
6. Early biomarker for pancreatic cancer identified
7. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
8. Back Pain Therapy Often Yields Early Benefits: Study
9. Revenue-driven surgery drives patients home too early
10. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
11. Southeast program to fight diabetes awarded nearly $10 million by HHS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... Petersburg, Fla. (PRWEB) , ... December 05, 2016 , ... ... concussions have on the growing brains of young athletes. Over the course of three ... the head through unique mouth guards. The mouth guards, equipped with special sensors, will ...
(Date:12/5/2016)... ... December 05, 2016 , ... Progressive ... of L-Citrulline and glutathione to enhance production of nitric oxide (NO). , NitroGenesis ... shown to produce NO twice as effectively and sustains NO blood levels twice ...
(Date:12/5/2016)... Missouri (PRWEB) , ... December 05, 2016 , ... ... ethnic, gender, and geographic lines. The goal of Castlewood Treatment Centers has always ... treatment accessible to as many people as possible. In that spirit, Castlewood ...
(Date:12/5/2016)... ... ... U.S. Apple Association (USApple) begins the holiday giving season by donating $17,800 to ... Buy an Apple, Help a Student fundraising campaign. , Winning ideas ... their families; solar technology to efficiently process compost; and iPads to enhance student learning. ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... portfolio company, today announced it has acquired the assets of Frankfurt, Germany ... a subsidiary of Chiltern International and focuses on clinical trial drug packaging, ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 5, 2016  Recently Zymo Research announced an ... known as Horvath,s Clock. Based on this technology, ... service to academic and biopharma scientific researchers to ... other than sperm. The service quantifies ... age versus chronological age following drug treatments and ...
(Date:12/5/2016)... Ill. , Dec. 5, 2016 For ... score on the 2017 Human Rights Campaign Foundation,s ... The CEI is a national benchmarking tool used to ... bisexual, and transgender (LGBT) employee equality. For ... Survey to help companies gauge their equality efforts, culture ...
(Date:12/5/2016)... WOODCLIFF LAKE, N.J. , Dec. 5, 2016 /PRNewswire/ ... on perampanel presented at the 2016 Annual Meeting of ... marketed as FYCOMPA® CIII, is indicated as an adjunctive ... with or without secondarily generalized seizures and primary generalized ... 12 years of age and older. Please see Important ...
Breaking Medicine Technology: