Navigation Links
Early life stress may take early toll on heart function
Date:2/21/2013

AUGUSTA, Ga. Early life stress like that experienced by ill newborns appears to take an early toll of the heart, affecting its ability to relax and refill with oxygen-rich blood, researchers report.

Rat pups separated from their mothers a few hours each day, experienced a significant decrease in this basic heart function when as life tends to do an extra stressor was added to raise blood pressure, said Dr. Catalina Bazacliu, neonatologist at the Medical College of Georgia and Children's Hospital of Georgia at Georgia Regents University. Bazacliu worked under the mentorship of Dr. Jennifer Pollock, biochemist in the Section of Experimental Medicine in the MCG Department of Medicine.

The relaxation and filling rate remained low in the separation model, although decreases stabilized by ages two and six months, as the rats neared middle age. Both the model and controls experienced decreases in those functions that come naturally with age.

Interestingly, the force with which the heart ejected blood remained unchanged with the additional stressor, angiotensin II, a powerful constrictor of blood vessels. Echocardiography was used to evaluate heart function.

"We expected the heart's ability to relax and refill to lag behind in our model," said Bazacliu, whose research earned her a Young Investigator Award from the Southern Society for Pediatric Research. She is reporting her findings Feb. 22 during the Southern Regional Meetings in New Orleans, sponsored by the society as well as several other groups including the Southern Section of the American Federation for Medical Research.

"We believe these babies may be at increased risk for cardiovascular disease and we are working to understand exactly what puts them at risk," Bazacliu said. She believes hers is the first animal study of this aspect of heart function.

Dr. Analia S. Loria, assistant research scientist in Pollock's lab and also a co-author on the new abstract, has shown that the blood pressure of maternally separated rats goes up more in response to angiotensin II and their heart rates go higher as well. Normally, a compensatory mechanism drives the heart rate down a little when blood pressure goes up.

Work by others has shown persistent blood vessel changes in the early stress model, including increased contraction and reduced relaxation when similarly stressed.

Longitudinal studies in humans have shown long-term cardiovascular implications, such as babies born to mothers during the Dutch famine of World War II, growing up at increased risk for cardiovascular disease as well as diabetes, obesity and other health problems.

Bazacliu's earlier studies in a similar animal model indicated that babies whose growth was restricted in utero by conditions such as preeclampsia maternal high blood pressure during pregnancy were at increased risk of cardiovascular disease as adults. This was true whether the babies were born prematurely or at full term. Increased pressure during development reduces blood flow from mother to baby; reduced nutrition and oxygen to the baby is considered an environmental stress.

Bazacliu's interest in early life stress grew out of the reality that, while obviously intended to save premature and otherwise critically ill newborns, neonatal intensive care units can further stress these babies. "All the procedures we must do, the separation from the mother, the environment, even though the babies need the help, it represents a stress." NICUs such as the one at Children's Hospital of Georgia work to minimize negative impact with strategies such as open visiting hours, minimalizing noise and other family-centered care strategies.

Bazacliu came to MCG in 2011 from the University of Buffalo School of Medicine and Biomedical Sciences.


'/>"/>

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

Related medicine news :

1. Early Exposure to Gluten May Help Babies Avoid Celiac Risk: Study
2. Youth Smoking, Obesity May Lead to Early Death
3. Early education closes achievement gap, brings societal benefits
4. JCI early table of contents for Feb. 15, 2013
5. Those Childhood Piano Lessons Should Start Early
6. Deep Brain Stimulation May Help in Early Stages of Parkinsons
7. Researchers identify genetic root to early-onset prostate cancer
8. Early Dental Care Can Help Keep Kids Smiling for Years to Come
9. JCI early table of contents for Feb. 8, 2013
10. Students in Educational First Steps Assisted Centers Show Persistent Benefits Far Beyond Early Childhood According to University of Texas at Dallas Study
11. Exposure to Smog in Early Pregnancy Linked to Complications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Early life stress may take early toll on heart function
(Date:2/13/2016)... (PRWEB) , ... February 13, 2016 , ... ... School of Nursing with an in-kind gift of a VeinViewer® Vision vein ... as they learn how to start an IV and draw blood, combining technology ...
(Date:2/13/2016)... ... February 13, 2016 , ... DDi ... Management Solution Providers list for its expertise in eClinical Solutions. DDi has built ... serve the technology needs of global clients. DDi provides smarter technology for Clinical ...
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of Morrow, Morrow, Ryan & ... purpose of these scholarships is to encourage applicants to pursue a degree in their ... these two parishes. , “We have available jobs in St. Landry and Evangeline ...
(Date:2/12/2016)... ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , ... , As Winston Churchill said, “Those who don’t learn from history are doomed to ... expect when they come knocking this year. But that takes time. , Take a ...
(Date:2/12/2016)... , ... February 12, 2016 , ... As a former ... schedule, a demanding job, and no time to decompress, Rabinowitz found herself drawn to ... to meditation for its impact on her life, implementing a 20-minute-per-day meditation practice with ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- - Cardiac Marker Diagnostic Testing ... Cancer Therapy. - European Point of Care Diagnostic ... - Key Diagnostic Testing Markets. - Molecular Diagnostics ... Testing. - Molecular Diagnostics in Infectious Disease Testing. ... Products World Markets. - Point of Care Diagnostic ...
(Date:2/11/2016)... Feb. 11, 2016 Stem cells are primitive ... by self-renewal and the capacity to differentiate into mature ... discovery, as the first mouse embryonic stem cells were ... until 1995 that the first culturing of embryonic stem ... were not produced until 2006 As a result of ...
(Date:2/11/2016)... 11, 2016 Laboratory glassware and ... laboratories. These may range from microscope slides to large ... made from borosilicate glass because of its low weight ... other hand, started gaining popularity over the past decade ... replace glass with plastic in several applications due to ...
Breaking Medicine Technology: