Navigation Links
Early life stress may predict cardiovascular disease
Date:2/9/2010

Early life stress could be a risk factor for cardiovascular disease in adulthood, researchers report.

"We think early life stress increases sensitivity to a hormone known to increase your blood pressure and increases your cardiovascular risk in adult life," said Dr. Jennifer Pollock, biochemist in the Vascular Biology Center at the Medical College of Georgia and corresponding author on the study published online in Hypertension.

The studies in a proven model of chronic behavioral stress separating rat pups from their mother three hours daily for two weeks showed no long-term impact on key indicators of cardiovascular disease such as increased blood pressure, heart rate or inflammation in blood vessel walls.

But when the rats reached adulthood, an infusion of the hormone angiotensin II resulted in rapid and dramatic increases in all key indicators in animals that experienced early life stress. Stress activates the renin-angiotensin system which produces angiotensin II and is a major regulator of blood vessel growth and inflammation both heavily implicated in heart disease. "They cannot adapt to stress as well as a normal animal does," Dr. Pollock said. Within a few days, for example, blood pressure was nearly twice as high in the early-stress animals.

The chronic stress model most typically has been used to look at the psychological impact of childhood stress; this was the first time it was used to measure cardiovascular impact, Dr. Pollock said. Findings correlate with studies published in Circulation in 2004 that identified adverse childhood events, such as abuse or parental loss, in the backgrounds of many adults with ischemic heart disease.

"We want to be able to prevent this long-term consequence," said Dr. Analia S. Loria, MCG postdoctoral fellow and the study's first author. Although the adult rats seemed fine until stressed, the scientists noted the inevitability of stress in life.

Next steps include determining the mechanism that translates early life stress into cardiovascular risk; they suspect it results in genetic alterations at a vulnerable time in development. "Hormones can modulate gene expression and, during stress, you have very high levels of stress hormone," Dr. Loria said.

To further test the findings. they are blocking the angiotensin II receptor in rats to see if that decreases the cardiovascular impact in animals with early life stress. And, to more closely mimic what happens in real life, they are feeding high-fat diets to the rats to see if, like the angiotensin II infusions, it exaggerates cardiovascular disease risk. Receptor blockers are commonly used in cardiovascular patients who have high levels of angiotensin II.

The scientists also will be studying gender differences in response to early life stress since their initial studies were in male rats. Psychological studies indicate that females are less impacted by early life stress and the scientists predict they will find similar results in the cardiovascular response.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related medicine news :

1. Pot bellies linked to early signs of cardiovascular disease
2. Eye-staining technique offers early detection for dry eye syndrome
3. Early Weight Loss in Women Linked to Dementia
4. Isolation of a new gene family essential for early development
5. U of M study: Early treatment can reverse heart damage
6. Gerresheimer to be Included in the SDAX Early Decision on Inclusion in the MDAX on September 5, 2007
7. Rock N Roll: Sex, Drugs and an Early Exit
8. Pop stars more than twice as likely to die an early death
9. Exercise and yoga improves quality of life in women with early-stage breast cancer
10. Research says doctors gender may hinder early diagnosis of heart disease in women
11. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Early life stress may predict cardiovascular disease
(Date:5/26/2016)... ... May 26, 2016 , ... Saint Francis Hospital ... years, and the efforts have paid off. Since implementation of these efforts, ... care to enhance perioperative patient experiences and reduce costly complications. Since implementation in ...
(Date:5/26/2016)... ... May 26, 2016 , ... Development Team of Pixel ... for FCPX. , "This new layered style transition tool will keep a consistent flow ... CEO of Pixel Film Studios. , TranSweep is an all new layered style ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... industry leader in Blood Pressure products . , High blood pressure affects ... effects. Left untreated, high blood pressure can lead to heart disease, stroke, kidney ...
(Date:5/25/2016)... ... May 26, 2016 , ... The United States Food and Drug Administration ... both men and women. To date, the company is the first and only manufacturer ... adult who suffers with androgenetic alopecia. , “This new level of clearance substantiates ...
(Date:5/25/2016)... ... 25, 2016 , ... The Georgia State University College of Law new building ... Design Commission. , The annual award recognizes projects, programs, individuals and organizations that have ... of its physical heritage and the balance between the old and the new. , ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LONDON , May 24, 2016 ... erfüllt beide primären Endpunkte ... und Überlegenheit in ‚ausgezeichneter plus guter ... aufsteigenden Colons    ,      (Logo: ... B.V. gab heute neue positive Daten von der ...
(Date:5/24/2016)... -- NxStage Medical, Inc. (Nasdaq: NXTM ), a ... today announced that Jeffrey H. Burbank , Chief ... of investor conferences. Where applicable, a webcast of the ...   ... Friday, June 10, 2016 1:30 p.m. ET ...
(Date:5/24/2016)... HONG KONG , May 24, 2016 /PRNewswire/ ... primer stent de doble terapia del mundo, introduce ... fístula arteriovenosa. OrbusNeich, una compañía global ... cambian las vidas, ha expandido su cartera incluyendo ... catéteres balón JADE™ y Scoreflex™ PTA son los ...
Breaking Medicine Technology: