Navigation Links
Early life stress may predict cardiovascular disease

Early life stress could be a risk factor for cardiovascular disease in adulthood, researchers report.

"We think early life stress increases sensitivity to a hormone known to increase your blood pressure and increases your cardiovascular risk in adult life," said Dr. Jennifer Pollock, biochemist in the Vascular Biology Center at the Medical College of Georgia and corresponding author on the study published online in Hypertension.

The studies in a proven model of chronic behavioral stress separating rat pups from their mother three hours daily for two weeks showed no long-term impact on key indicators of cardiovascular disease such as increased blood pressure, heart rate or inflammation in blood vessel walls.

But when the rats reached adulthood, an infusion of the hormone angiotensin II resulted in rapid and dramatic increases in all key indicators in animals that experienced early life stress. Stress activates the renin-angiotensin system which produces angiotensin II and is a major regulator of blood vessel growth and inflammation both heavily implicated in heart disease. "They cannot adapt to stress as well as a normal animal does," Dr. Pollock said. Within a few days, for example, blood pressure was nearly twice as high in the early-stress animals.

The chronic stress model most typically has been used to look at the psychological impact of childhood stress; this was the first time it was used to measure cardiovascular impact, Dr. Pollock said. Findings correlate with studies published in Circulation in 2004 that identified adverse childhood events, such as abuse or parental loss, in the backgrounds of many adults with ischemic heart disease.

"We want to be able to prevent this long-term consequence," said Dr. Analia S. Loria, MCG postdoctoral fellow and the study's first author. Although the adult rats seemed fine until stressed, the scientists noted the inevitability of stress in life.

Next steps include determining the mechanism that translates early life stress into cardiovascular risk; they suspect it results in genetic alterations at a vulnerable time in development. "Hormones can modulate gene expression and, during stress, you have very high levels of stress hormone," Dr. Loria said.

To further test the findings. they are blocking the angiotensin II receptor in rats to see if that decreases the cardiovascular impact in animals with early life stress. And, to more closely mimic what happens in real life, they are feeding high-fat diets to the rats to see if, like the angiotensin II infusions, it exaggerates cardiovascular disease risk. Receptor blockers are commonly used in cardiovascular patients who have high levels of angiotensin II.

The scientists also will be studying gender differences in response to early life stress since their initial studies were in male rats. Psychological studies indicate that females are less impacted by early life stress and the scientists predict they will find similar results in the cardiovascular response.


Contact: Toni Baker
Medical College of Georgia

Related medicine news :

1. Pot bellies linked to early signs of cardiovascular disease
2. Eye-staining technique offers early detection for dry eye syndrome
3. Early Weight Loss in Women Linked to Dementia
4. Isolation of a new gene family essential for early development
5. U of M study: Early treatment can reverse heart damage
6. Gerresheimer to be Included in the SDAX Early Decision on Inclusion in the MDAX on September 5, 2007
7. Rock N Roll: Sex, Drugs and an Early Exit
8. Pop stars more than twice as likely to die an early death
9. Exercise and yoga improves quality of life in women with early-stage breast cancer
10. Research says doctors gender may hinder early diagnosis of heart disease in women
11. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
Post Your Comments:
Related Image:
Early life stress may predict cardiovascular disease
(Date:12/1/2015)... ... 01, 2015 , ... Florida Hospital Tampa is the first health care provider in ... of Florida. , vBloc® Therapy is a vagal blocking therapy, delivered via the Maestro® System, ... mass index (BMI) of at least 40 to 45 kg, or a BMI of at ...
(Date:12/1/2015)... ... ... Dr. Paul Vitenas, one of the top cosmetic surgeons in Texas ... the Best Single Physician Practice in the nation. Dr. Vitenas and his practice were ... the industry publication. , Dr. Vitenas said he was very honored to receive ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... the 7th Annual 2015 Golden Bridge Business Awards under the New Products and ... zero capex web based sample management software that helps labs organize ...
(Date:12/1/2015)... ... December 01, 2015 , ... For ... mark the film for accurate interpretation by the radiologist. The marking utensils are ... from Sacramento, Calif., has found a way to alleviate this problem. , He ...
(Date:12/1/2015)... ... December 01, 2015 , ... McLean, VA., December ... a fixed price per sprint agile development contract to support the National Geospatial-Intelligence ... five years, provides software engineering, infrastructure, as well as operations and sustainment support ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... VERONA, Virginia , 1 de diciembre ... líder en tecnología para cuchillas de precisión, ... un programa de identidad de marca. El ... en el diseño y la ingeniería de ... toda la diferencia". ...
(Date:12/1/2015)... 2015 During the recent 2015 Transcatheter ... Francisco, CA , Medinol Ltd. continued to ... During a satellite symposium, "The BioNIR eDES: The ... Restenosis", a renowned physician panel discussed the key ... Coronary Stent System and the Medinol eDES Coronary ...
(Date:12/1/2015)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company developing ... that the company will present at the LD Micro Main ... Luxe Sunset Boulevard Hotel in Los Angeles, CA. ... will present on Thursday, December 3, at 9:00 am Pacific ... register at least 10 minutes prior to the start of ...
Breaking Medicine Technology: